| Interacting proteins: P42858 and P08047 |
Pubmed |
SVM Score :0.79885937 |
| Here , we report that huntingtin interacts with the transcriptional activator Sp 1 and coactivator TAFII 130 . 0.79885937^^^ |
|
| Interacting proteins: P42858 and P08047 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42858 and P08047 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42858 and P08047 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42858 and P08047 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42858 and P08047 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42858 and P08047 |
Pubmed |
SVM Score :0.50796904 |
| Here we report that huntingtin interacts with Sp 1 , a transcription factor that binds to GC rich elements in certain promoters and activates transcription of the corresponding genes . 0.50796904^^^ |
|
| Interacting proteins: P42858 and P08047 |
Pubmed |
SVM Score :0.0 |
| O tetradecanoyl phorbol 13 acetate down regulates the Huntingtin promoter at Sp 1 sites . ^^^ |
|
| Interacting proteins: P42858 and P08047 |
Pubmed |
SVM Score :0.0 |
| Several transcription factors that have been shown to interact with mutant huntingtin , including Sp 1 , neuron restrictive silencing factor , TATA binding protein and cAMP response element binding protein , are unlikely to be involved in mutant huntingtin induced PDE10A2 transcriptional dysregulation . . ^^^ |
|
| Interacting proteins: P42858 and P08047 |
Pubmed |
SVM Score :0.0 |
| These findings suggest that mutant huntingtin dissociates Sp 1 from target promoters , inhibiting transcription of specific genes . . ^^^ |
|
| Interacting proteins: P42858 and P08047 |
Pubmed |
SVM Score :0.0 |
| Neither Hdh nor the HD gene have typical TATA or CCAAT elements , but both show one putative AP 2 binding site and numerous potential Sp 1 binding sites . ^^^ |
|
| Interacting proteins: P42858 and P08047 |
Pubmed |
SVM Score :0.0 |
| To test this hypothesis , we examined the expression and localization of the polyglutamine containing or glutamine rich transcription factors TBP , CBP and Sp 1 in HD mouse models . ^^^ |
|
| Interacting proteins: P42858 and P08047 |
Pubmed |
SVM Score :0.0 |
| We found increased levels of Sp 1 in neuronal like PC 12 cells expressing mutant Htt , primary striatal neurons , and brain tissue of HD transgenic mice . ^^^ To assess the effects of knocking down Sp 1 in HD pathology , we used Sp 1 siRNA , a heterozygous Sp 1 knock out mouse , and mithramycin A , a DNA intercalating agent that inhibits Sp 1 function . ^^^ In addition , when HD mice were crossed with Sp 1 heterozygous knock out mice , the resulting offspring did not experience the loss of dopamine D 2 receptor mRNA characteristic of HD mice , and survived longer than their HD counterparts . ^^^ Our data suggest that enhancement of transcription factor Sp 1 contributes to the pathology of HD and demonstrates that its suppression is beneficial . . ^^^ |
|
| Interacting proteins: P42858 and P08047 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that both gene specific activator protein Sp 1 and selective components of the core transcription apparatus , including TFIID and TFIIF , are direct targets inhibited by mutant htt in a polyglutamine dependent manner . ^^^ |
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