| Interacting proteins: P42858 and P00533 |
Pubmed |
SVM Score :0.52871528 |
| SH 3 domain dependent association of huntingtin with epidermal growth factor receptor signaling complexes . 0.52871528^^^ |
|
| Interacting proteins: P42858 and P00533 |
Pubmed |
SVM Score :0.57196217 |
| We reported previously that normal Huntingtin is associated with epidermal growth factor receptor ( EGF ) signaling complex ( Liu , Y . 0.57196217^^^ |
|
| Interacting proteins: P42858 and P00533 |
Pubmed |
SVM Score :0.0 |
| Here , we show that huntingtin associated protein 1 ( HAP 1 ) , which is involved in intracellular trafficking of epidermal growth factor receptor ( EGFR ) , is highly expressed in the hypothalamus . ^^^ Inhibition of HAP 1 expression decreases EGFR signaling and cell viability , whereas overexpression of HAP 1 enhances this signaling activity and inhibits mutant huntingtin mediated cytotoxicity . ^^^ These results suggest that the effect of mutant huntingtin on HAP 1 and EGFR signaling may contribute to the hypothalamic neurodegeneration and loss of body weight in HD . . ^^^ |
|
| Interacting proteins: P42858 and P00533 |
Pubmed |
SVM Score :0.0 |
| HI tumors contained 2 . 5 to 3 fold higher EGFR levels than HD / HR tumors , an observation which shows remarkable concordance with studies on EGFR in human breast cancer . ^^^ On the other hand , the level of EGFR ligand ( s ) was positively associated with ER levels and was three fold higher in HD / HR tumors than in HI tumors . ^^^ The low EGFR in HD / HR tumors relative to HI tumors may be the result of downregulation by EGFR ligands produced under ER control . ^^^ |
|
| Interacting proteins: P42858 and P00533 |
Pubmed |
SVM Score :0.0 |
| This suggests that disruption of EGFR signaling and ensuing glial cell dysfunction could play a direct role in the pathogenesis of HD and other polyQ diseases in humans . . ^^^ |
|
| Interacting proteins: P42858 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
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