| Interacting proteins: P42858 and O75400 |
Pubmed |
SVM Score :0.0 |
| Among these , we identified a major interactor class , comprising three distinct WW domain proteins , HYPA , HYPB and HYPC , that bind normal and mutant huntingtin in extracts of HD lymphoblastoid cells . ^^^ |
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| Interacting proteins: P42858 and O75400 |
Pubmed |
SVM Score :0.0 |
| FNBP 3 , binding to TNFSF 6 ( Fas ligand ) , Huntingtin and Formin proteins , might transduce extracellular signals to the Rho related signaling pathway . ^^^ |
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| Interacting proteins: P42858 and O75400 |
Pubmed |
SVM Score :0.0 |
| Interaction of the nuclear matrix protein NAKAP with HypA and huntingtin : implications for nuclear toxicity in Huntington ' s disease pathogenesis . ^^^ Recently , several nuclear interaction partners for huntingtin have been identified , including HypA , a splicing factor like protein of unknown function . ^^^ Furthermore , NAKAP associates with HypA from human brain and copurifies with huntingtin protein in brain tissue obtained from HD patients . ^^^ Hence , the NAKAP HypA scaffold is a potential nuclear docking site for huntingtin protein and may contribute to the nuclear accumulation of huntingtin observed in HD . . ^^^ |
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