| Interacting proteins: O75376 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75376 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75376 and P42858 |
Pubmed |
SVM Score :0.0 |
| Cystathionine beta synthase was not relocalized in HD brain , but the N CoR was excluded from neuronal nuclei in HD brain , and a further protein that exists in the same repression complex , mSin 3 , was similarly excluded . ^^^ |
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| Interacting proteins: O75376 and P42858 |
Pubmed |
SVM Score :0.0 |
| We have used N CoR and mSin3A antibodies in immunohistochemical studies and find that in Huntington ' s disease ( HD ) cortex and caudate , the cellular localization of these proteins is exclusively cytoplasmic whilst in control brain they are localized in the nucleus as well as the cytoplasm ; mSin3A immunoreactivity also occurred in a subset of huntingtin positive intranuclear inclusions . ^^^ We detected an interaction of the N terminus of huntingtin ( htt 171 ) with the C terminal region of the nuclear receptor co repressor ( N CoR ) using the yeast two hybrid system . ^^^ |
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| Interacting proteins: O75376 and P42858 |
Pubmed |
SVM Score :0.0 |
| There is growing evidence that truncated forms of mutant Htt in the nucleus influence gene transcription by binding to proteins such as CREB binding protein ( CBP ) response element binding protein binding protein , N COR , glyceraldehyde 3 phosphate dehydrogenase , and p 53 . p 53 regulates the transcription of various mitochondrial proteins which may underlie the mitochondrial abnormalities , especially the vulnerability to mitochondrial depolarization , seen in HD tissues . ^^^ |
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