| Interacting proteins: O14776 and P42858 |
Pubmed |
SVM Score :0.0 |
| To identify the genetic modifier ( s ) that might alter the age at onset in Huntington ' s disease ( HD ) we have analyzed variations in GluR 6 kainate receptor ( GluR 6 ) , CA 150 gene , Delta 2642 and polymorphic CCG repeat variation in huntingtin ( htt ) gene in 77 HD patients and normal individuals . ^^^ Specific alleles in GluR 6 and CA 150 locus were only observed in HD patients . . ^^^ |
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| Interacting proteins: O14776 and P42858 |
Pubmed |
SVM Score :0.0 |
| We hypothesized that these mechanisms may involve the dysfunction of the transcriptional regulator CA 150 , a putative modifier of onset age in HD , because it binds to htt and accumulates in an HD grade dependent manner in striatal and cortical neurons . ^^^ Consistently , we report herein that CA 150 expression rescues striatal cell death in lentiviral overexpression ( rats ) and knock in ( mouse cells ) conditions for mutant htt neurotoxicity . ^^^ Together , our data indicate that mutant htt may induce CA 150 dysfunction in striatal neurons and suggest that the restoration of nuclear protein cooperativity may be neuroprotective . . ^^^ CA 150 expression delays striatal cell death in overexpression and knock in conditions for mutant huntingtin neurotoxicity . ^^^ |
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| Interacting proteins: O14776 and P42858 |
Pubmed |
SVM Score :0.90085873 |
| CA 150 interacted in vitro with full length htt from lymphoblastoid cells . 0.90085873^^^ The Gln Ala repeat transcriptional activator CA 150 interacts with huntingtin : neuropathologic and genetic evidence for a role in Huntington ' s disease pathogenesis . 0.52833993^^^ |
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