| Coexpression of Sp 1 and TAFII 130 in cultured striatal cells from wild type and HD transgenic mice reverses the transcriptional inhibition of the dopamine D 2 receptor gene caused by mutant huntingtin , as well as protects neurons from huntingtin induced cellular toxicity . ^^^ Here , we report that huntingtin interacts with the transcriptional activator Sp 1 and coactivator TAFII 130 . ^^^ |