| Interacting proteins: Q8N143 and P41182 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q8N143 and P41182 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q8N143 and P41182 |
Pubmed |
SVM Score :0.0 |
| We cloned a novel Bcl 6 homologous gene , BAZF ( encoding Bcl 6 associated zinc finger protein ) . ^^^ BAZF , a novel Bcl 6 homolog , functions as a transcriptional repressor . ^^^ BAZF associated with Bcl 6 at the BTB / POZ domain and localized in the nucleus . ^^^ Since zinc finger motifs of BAZF were 94 % identical to those of Bcl 6 at the amino acid level , BAZF bound specifically to the DNA binding sequence of Bcl 6 and functioned as a transcriptional repressor . ^^^ The 17 amino acid sequence in the middle portion was completely conserved between BAZF and Bcl 6 , and the conserved region was critical for the repressor activity . ^^^ |
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| Interacting proteins: Q8N143 and P41182 |
Pubmed |
SVM Score :0.0 |
| BAZF , a family member of Bcl 6 , can function as a sequence specific transcriptional repressor . ^^^ The consensus binding sequence ( CBS ) of BAZF is almost the same as those of Bcl 6 previously described . ^^^ Three nucleotides of T , G and A at position 6 , 8 , and 9 in the CBS ( 5 ' ATTCCTAGAAAG 3 ' ) are important nucleotides for binding of both BAZF and Bcl 6 . ^^^ Since a part ( 5 ' TTC CTA GAA 3 ' ) of the CBS resembled the sequence motif ( 5 ' TTC ( N 3 4 ) GAA 3 ' ) bound by STAT factors , BAZF and Bcl 6 can bind to the CD23b STAT 6 binding sequence ( 5 ' TTTC TTA GAAAT 3 ' ) , the immunoglobulin germline epsilon STAT 6 binding sequence ( 5 ' CTTC CCAA GAAC 3 ' ) , and the IL 4 STAT6 binding sequence ( 5 ' TTTC CCA GAAAA 3 ' ) with weak affinity . ^^^ However , a mutation of C nucleotide to T nucleotide in the IL 4 STAT6 binding sequence ( 5 ' TTTC CTA GAAAA 3 ' ) strongly increased the binding activity of BAZF and Bcl 6 . ^^^ |
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| Interacting proteins: Q8N143 and P41182 |
Pubmed |
SVM Score :0.0 |
| The proto oncogene Bcl 6 and its family gene , BAZF , encode a sequence specific transcriptional repressor which contains the BTB / POZ domain in NH ( 2 ) terminal region and zinc finger motifs in COOH terminal region . ^^^ The BTB / POZ domain and the middle portion of Bcl 6 and BAZF are known to display transrepressor activity . ^^^ Since we have identified the identical 17 amino acid ( aa ) sequence in the middle portion of Bcl 6 and BAZF , the 17aa region may be another repressive domain of the middle portion . ^^^ |
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| Interacting proteins: Q8N143 and P41182 |
Pubmed |
SVM Score :0.0 |
| Cloning and characterization of the human BAZF gene , a homologue of the BCL 6 oncogene . ^^^ The BAZF gene has recently been identified as a novel homologue of the BCL 6 oncogene . ^^^ |
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| Interacting proteins: Q8N143 and P41182 |
Pubmed |
SVM Score :0.0 |
| Bcl 6 dependent transcriptional repression by BAZF . ^^^ BAZF , a member of Bcl 6 gene family , acts as a sequence specific transcriptional repressor in various cells including NIH3T3 cells . ^^^ The DNA binding sequence for BAZF is the same as that for Bcl 6 and the repressor activity of BAZF was also inhibited by Tricostatin A , an inhibitor of histone deacetylase , suggesting the functional homology between them . ^^^ However , BAZF unlike Bcl 6 can not function as a transcriptional repressor in embryonal fibroblasts of Bcl 6 deficient mice and in Bcl 6 null cell lines such as K 562 and WIL 2 NS . ^^^ The BTB / POZ domain and the middle portion of BAZF bound to the BTB / POZ domain and the middle portion of Bcl 6 , respectively . ^^^ |
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| Interacting proteins: Q8N143 and P41182 |
Pubmed |
SVM Score :0.0 |
| BAZF , a member of the Bcl 6 gene family , acts as a sequence specific transcriptional repressor in association with Bcl 6 . ^^^ However , the tissue expression pattern of BAZF differs from that of Bcl 6 , suggesting a Bcl 6 independent function of BAZF . ^^^ Since cell proliferation of naive CD 4 T cells of lck Bcl 6 mice to anti CD 3 antibody stimulation was severely impaired , BAZF may attenuate the regulatory effect of Bcl 6 on antigenic activation of naive CD 4 T cells by Bcl6 / BAZF heterodimer formation . ^^^ |
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| Interacting proteins: Q8N143 and P41182 |
Pubmed |
SVM Score :0.0 |
| We have examined for this function the transcriptional repressor BCL6b , a homologue of BCL 6 that represses IL 2 induced B cell differentiation . ^^^ |
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