| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| The genes selected by the system included genes that are informative in the prognosis of Diffuse large B cell lymphoma ( DLBCL ) , such as genes showing an expression pattern similar to that of CD 10 and BCL 6 or similar to that of IRF 4 and BCL 4 . ^^^ |
|
| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| All lesions were investigated applying standard immunohistochemical methods with antibodies specific for pRB , p 53 , p 16 , p 21 , BCL 6 and for multiple myeloma oncogene 1 protein ( MUM 1 , also known as IRF 4 ) . ^^^ |
|
| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| The transactivating ability of IRF 4 is blocked by the repressor factor BCL 6 . ^^^ |
|
| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| They are not apoptotic , some are proliferating , they express germinal center markers peanut agglutinin or CD 10 but not Bcl 6 , and most express CD 138 ( syndecan 1 ) , IRF 4 , and cytoplasmic Ig . ^^^ |
|
| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| DESIGN AND METHODS : We analyzed 90 tumors ( 20 LPL , 41 MALT lymphomas , 12 N MZL , 17 S MZL ) , investigating the expression of CD 5 , CD 10 , CD 20 , CD 23 , CD 27 , CD 38 , CD79a , CD 138 , Bcl 6 , cyclin D 1 , IRF 4 and Ki 67 antigens by immunohistochemistry . ^^^ |
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| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| TMA were tested with specific antibodies against CD 10 , CD 20 , CD 30 , CD79a , CD 138 , Bcl 2 , Bcl 6 , IRF 4 , and IRTA 1 . ^^^ RESULTS : The following phenotypic subclassification was made : a ) CD 10 + / Bcl 6 + or Bcl 6+ / IRF4 + , but Bcl 2 / CD30 / CD138 suggesting B cells gathering / leaving the germinal center ( group 1 ; n=36 ) ; b ) Bcl 2+ / CD10 / Bcl 6 and CD30+ or CD138+ corresponding to putative non germinal center B cells with features of activation or plasmablastic / plasmacellular differentiation ( group 2 ; n=17 ) ; c ) CD 30 / CD138 with extensive Bcl 2 positivity and variable CD 10 , Bcl 6 and IRF 4 combinations ( group 3 ; n=15 ) . ^^^ |
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| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| Also , the expression patterns of bcl 6 , CD 10 and IRF 4 ( also known as MUM 1 ) have been suggested as alternative means of identifying the germinal and nongerminal center ( activated B cell like ) groups . ^^^ In the present study , we evaluated by immunohistochemistry the expression patterns of CD 10 , bcl 6 , IRF 4 and bcl 2 in a large material of 161 DLBCL patients . ^^^ Positive staining for bcl 6 or CD 10 predicted for superior survival , while expression of IRF 4 alone showed no association with prognosis . ^^^ |
|
| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| MUM 1 was expressed in the nuclei and cytoplasm of plasma cells and a small percentage of germinal center ( GC ) B cells mainly located in the `` light zone . ' ' Its morphologic spectrum ranged from that of centrocyte to that of a plasmablast / plasma cell , and it displayed a phenotype ( MUM 1 ( + ) / Bcl 6 ( ) / Ki67 ( ) ) different from that of most GC B cells ( MUM 1 ( ) / Bcl 6 ( + ) / Ki67 ( + ) ) and mantle B cells ( MUM 1 ( ) / Bcl 6 ( ) / Ki67 ( ) ) . ^^^ Unlike normal GC B cells , in which the expression of MUM 1 and Bcl 6 were mutually exclusive , tumor cells in approximately 50 % of MUM 1 ( + ) DLCL B coexpressed MUM 1 and Bcl 6 , suggesting that expression of these proteins may be deregulated . ^^^ |
|
| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| In particular , MUM 1 may provide a marker for the identification of transition from BCL 6 positivity ( GC B cells ) to CD 138 expression ( immunoblasts and plasma cells ) . ^^^ |
|
| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| All of our cases of PCLBCL leg morphologically resembled diffuse large B cell lymphoma ( DLBCL ) , but to better define their histogenesis , we also analyzed various phenotypic and genotypic markers , including mutations of the Ig and of BCL 6 genes , as well as expression of the bcl 6 , MUM 1 , and CD138 / syndecan 1 proteins . ^^^ Immunohistochemically , all of our cases stained for the L 26 / CD20cy and CD79a antigens and expressed the bcl 2 , bcl 6 , and MUM 1 proteins but were negative for both the CD10 / CALLA and CD 138 antigens . ^^^ |
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| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| Cells from each patient were immunostained with CD 20 , CD79a , CD 5 , CD 10 , bcl 6 , MUM 1 , CD 138 , bcl 2 , p 53 , p 27 , and Ki 67 antibodies . ^^^ Four immunophenotyping profiles were distinguished according to the pattern of differentiation : germinal center CD 10 ( + ) ( GC CD 10 ( + ) ; CD 10 ( + ) / Bcl 6 ( + ) / MUM1 ( ) / CD138 ( ) ) , germinal center CD 10 ( ) ( GC CD 10 ( ) ; CD 10 ( ) / Bcl 6 ( + ) / MUM 1 ( ) / CD138 ( ) ) , post germinal center ( pGC ; CD 10 ( ) / bcl 6 ( + / ) / MUM 1 ( + ) / CD138 ( ) ) , and plasmablastic ( CD 10 ( ) / bcl 6 ( ) / MUM1 ( + ) / CD138 ( + ) ) . ^^^ Single antigen expression was as follows : CD 5 , 2 % ; CD 10 , 21 % ; bcl 6 , 72 % ; MUM 1 , 54 % ; CD 138 , 2 % ; bcl 2 , 59 % ; p 53 , 28 % ; p 27 , 40 % . ^^^ |
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| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| We investigated PBL of the oral cavity ( n = 12 ) for mutations of immunoglobulin variable heavy chain ( IgVH ) and BCL 6 genes , which are acquired by B cells at the time of germinal centre ( GC ) transit , and for expression of BCL 6 , MUM 1 and CD 138 , which distinguish GC B cells from post GC B cells . ^^^ |
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| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry for the following antigens was performed : BCL 6 ; BCL 2 ; MUM 1 ; CD 10 ; vs38c ; CD 138 ; CD 44 ; p 16 ; and p 53 . ^^^ |
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| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| The tumors were subclassified according to the criteria of the WHO classification and evaluated by immunohistochemistry for expression of antigens associated with germinal center ( GC ) and non GC stages of B cell differentiation ( bcl 6 , CD 10 , MUM 1 , VS38c , CD 138 , bcl 2 , and CD 44 ) . ^^^ |
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| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| Sections were stained with antibodies to CD 10 , bcl 6 , MUM 1 , FOXP 1 , cyclin D 2 , and bcl 2 . ^^^ Expression of bcl 6 ( P < . 001 ) or CD 10 ( P = . 019 ) was associated with better overall survival ( OS ) , whereas expression of MUM 1 ( P = . 009 ) or cyclin D 2 ( P < . 001 ) was associated with worse OS . ^^^ Cases were subclassified using CD 10 , bcl 6 , and MUM 1 expression , and 64 cases ( 42 % ) were considered GCB and 88 cases ( 58 % ) non GCB . ^^^ |
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| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| METHODS : Fifty two monoclonal PTLD were investigated for : 1 ) . somatic hypermutation of IgV genes by direct sequencing of IgV rearrangements ; 2 ) . expression of BCL 6 , MUM 1 and CD 138 proteins by immunohistochemistry ; 3 ) . aberrant hypermethylation of DAP kinase gene by methylation specific polymerase chain reaction ( PCR ) ; 4 ) . genotypic characterization of Epstein Barr virus ( EBV ) in EBV infected PTLD by PCR analysis of the prevalence of deletions in the carboxyterminal portion of the LMP 1 gene and for the definition of type 1 / type 2 EBV infection . ^^^ |
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| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| To elucidate the reason for which primary breast diffuse large B cell lymphoma has a poor clinical outcome , we investigated 15 patients with primary breast diffuse large B cell lymphoma ( stage IE ; 13 cases , stage IIE ; two cases ) by immunohistochemistry using various markers including CD 10 , Bcl 6 , MUM 1 and MIB 1 and by molecular analysis of the immunoglobulin heavy chain gene variable region . ^^^ Immunohistochemistry showed 0 / 15 ( positive cases / examined cases ) for CD 10 , 5 / 15 for Bcl 6 , 15 / 15 for MUM 1 , 10 / 15 for Bcl 2 , 2 / 15 for CD 5 and 4 / 15 for CD 40 . ^^^ |
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| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical staining with CD 20 , CD 44 , CD 21 , CD 5 , CD 10 , bcl 2 , bcl 6 , Ki 67 , p 53 , and multiple myeloma 1 ( MUM 1 ) was examined . ^^^ The second group lacked staining with bcl 6 and had an overall survival of 26 months , with a majority of these cases staining with MUM 1 . ^^^ CONCLUSIONS : Our study demonstrates the utility of TMAs in the analysis of PCLBCL and that expression of bcl 6 and MUM 1 correlates with survival . . ^^^ |
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| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| The present study investigates the significance of survivin and a novel monoclonal antibody ( MAb ) , T 332 , immunohistochemically for predicting the prognoses of DLBCL and its subtypes classified as germinal center B cell like type ( GCB ) and non GCB type ( NGCB ) based on the expression profiles of CD 10 , bcl 6 , and MUM 1 . ^^^ |
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| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| Ninety three cases of primary cutaneous LBCL were analyzed for clinicopathologic features , expression of several markers including Bcl 2 , Bcl 6 , MUM 1 , and FOX P 1 , in situ hybridization for Epstein Barr virus , and molecular analyses of IGH gene rearrangement and of Borrelia burgdorferi and human herpesvirus 8 DNA . ^^^ |
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| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| A panel of 3 antigens ( CD 10 , Bcl 6 , and MUM 1 ) was applied to categorize each case as either a `` germinal center B cell ( GCB ) phenotype ' ' or a `` non GCB phenotype . ' ' Of the 25 cases examined , 8 cases ( 32 % ) were classified as `` GCB phenotype ' ' and 17 cases ( 68 % ) were classified as `` non GCB phenotype . ' ' A FISH analysis revealed that t ( 14 ; 18 ) was detected in 2 of the 8 cases ( 25 % ) with the `` GCB phenotype ' ' but in none of the 17 `` non GCB phenotype ' ' cases . ^^^ |
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| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| DLBCLs were classified into GC and non GC phenotype according to the immunohistochemical expression of bcl 6 , CD 10 , and MUM 1 . ^^^ |
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| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| CD 10 , BCL 6 , MUM 1 , BCL 2 , and CD 138 antigens were immunohistochemically labeled on paraffin embedded sections ; the first 4 were positive in 2 . 4 % , 55 . 5 % , 92 . 6 % , and 55 . 5 % of the tumors , respectively . ^^^ |
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| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| After immunohistochemically staining tissue microarrays of BL and DLBCL for markers of GC ( bcl 6 , CD 10 , cyclin H ) and ABC ( MUM 1 , CD 138 , PAK 1 , CD 44 , bcl 2 ) , we scored each case for the percentage of positive cells . ^^^ |
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| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| Analysis of phenotypic markers of B cell histogenesis , namely BCL 6 , MUM 1 and CD 138 , allows further distinction of PTLD histogenetic categories . ^^^ |
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| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| In this study we aimed to develop an algorithm based on expression of GCB / ABC related proteins CD 10 , Bcl 6 and MUM 1 and apoptosis inhibiting proteins Bcl 2 , XIAP and cFLIP for optimal stratification of DLBCL patients into prognostically favourable and unfavourable groups . ^^^ |
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| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| We immunohistochemically stained tissue microarrays of 39 de novo diffuse large B cell lymphomas : 12 AIDS associated and 27 non AIDS , with germinal center ( BCL 6 , CD 10 , CyclinH ) and activated B cell markers ( MUM 1 , CD 138 , PAK 1 , CD 44 , BCL 2 ) . ^^^ |
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| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry for CD 10 , BCL 6 , MUM 1 , vs38c , CD 138 , and BCL 2 was done . ^^^ CD 10 , BCL 6 , and MUM 1 expression results were used to classify all cases into the germinal center B cell ( GCB ) or the non GCB subgroup . ^^^ |
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| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| We proposed a hypothesis that Fas / FasL expression could be possibly related with a better survival of GC type DLBCL and evaluated 69 DLBCL cases immunohistochemically with CD 10 , Bcl 6 , MUM 1 , Fas and FasL . ^^^ These lymphomas were classified as GC type ( positive for CD 10 or Bcl 6 and negative for MUM 1 ) or NGC type . ^^^ |
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| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| Ninety eight B cell lymphomas ( 28 FCL , 5 MCL , and 65 DLBCL ) were analyzed by immunohistochemical examination for p 63 , bcl 6 , CD 10 and MUM 1 proteins , and for rearrangement of bcl 2 / IgH . ^^^ In DLBCL , the expression of p 63 and bcl 6 showed a significant correlation ( P < 0 . 02 ) , but no correlation was observed between p 63 and expression of CD 10 , MUM 1 , or bcl 2 / IgH rearrangement . ^^^ |
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| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15306 and P41182 |
Pubmed |
SVM Score :0.0 |
| NA |
|