| Interacting proteins: P41182 and Q05516 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P41182 and Q05516 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P41182 and Q05516 |
Pubmed |
SVM Score :0.60680814 |
| These data indicate that a physical interaction between LAZ 3 and PLZF underlies their simultaneous recruitment onto multiproteic nuclear complexes , presumably involved in transcriptional silencing and whose integrity ( for APL ) and / or function ( for APL and NHL ) may be altered in oncogenesis . . 0.60680814^^^ The colocalization and the reciprocal ' rescue ' is the result of a direct interaction between LAZ 3 and PLZF , as indicated by yeast two hybrid assays , in vitro immunoprecipitations , and GST pull down experiments . 0.56027011^^^ |
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| Interacting proteins: P41182 and Q05516 |
Pubmed |
SVM Score :0.0 |
| PLZF , like BCL 6 , strongly represses transcription initiated from different promoters . ^^^ |
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| Interacting proteins: P41182 and Q05516 |
Pubmed |
SVM Score :0.0 |
| A variety of eukaryotic transcription factors , including the nuclear hormone receptors , Max Mad , BCL 6 , and PLZF , appear to mediate transcriptional repression through the ability to recruit a multiprotein corepressor complex to the target promoter . ^^^ |
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| Interacting proteins: P41182 and Q05516 |
Pubmed |
SVM Score :0.0 |
| Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF , PLZF RARalpha , and BCL 6 . ^^^ We report here that PLZF , and a structurally similar transcriptional repressor , BCL 6 , can interact with a variety of corepressor proteins in addition to SMRT , including the mSin3A protein and ( for PLZF ) histone deacetylase 1 . ^^^ Unexpectedly , these additional interactions with corepressor components are nonequivalent for these otherwise similar oncoproteins , suggesting that transcriptional repression by BCL 6 and by PLZF may differ in mechanism . ^^^ |
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| Interacting proteins: P41182 and Q05516 |
Pubmed |
SVM Score :0.0 |
| Kaiso thus belongs to a rapidly growing family of POZ ZF transcription factors that include the Drosophila developmental regulators Tramtrak and Bric brac , and the human oncoproteins BCL 6 and PLZF , which are causally linked to non Hodgkins ' lymphoma and acute promyelocytic leukemia , respectively . ^^^ In addition , Kaiso homodimerized via its POZ domain but it did not heterodimerize with BCL 6 , which heterodimerizes with PLZF . ^^^ |
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| Interacting proteins: P41182 and Q05516 |
Pubmed |
SVM Score :0.0 |
| BCL 6 encodes a POZ / Zn finger protein , a structure similar to that of many Drosophila developmental regulators and to another protein involved in a human hematopoietic malignancy , PLZF . ^^^ |
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| Interacting proteins: P41182 and Q05516 |
Pubmed |
SVM Score :0.0 |
| In the human B cell lymphoma ( BCL 6 ) and promyelocityc leukemia ( PLZF ) oncoproteins , this domain mediates transcriptional repression through its ability to recruit a silencing mediator of retinoid and thyroid hormone receptor ( SMRT ) / nuclear receptor corepressor ( N CoR ) mSin3A histone deacetylase ( HDAC ) complex , a mechanism shared with numerous transcription factors . ^^^ However , in striking contrast with BCL 6 and PLZF , both HIC 1 and gammaFBP B similarly fail to interact with members of the HDAC complexes ( SMRT / N CoR , mSin3A or HDAC 1 ) in vivo and in vitro . ^^^ |
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| Interacting proteins: P41182 and Q05516 |
Pubmed |
SVM Score :0.0 |
| Strikingly , BCoR interacts selectively with the POZ domain of BCL 6 but not with eight other POZ proteins tested , including PLZF . ^^^ |
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| Interacting proteins: P41182 and Q05516 |
Pubmed |
SVM Score :0.0 |
| Critical residues within the BTB domain of PLZF and Bcl 6 modulate interaction with corepressors . ^^^ A comparison of the PLZF , Bcl 6 , and the FAZF ( Fanconi anemia zinc finger ) / ROG protein shows that variations in the BTB pocket result in differential affinity for corepressors , which predicts the potency of transcriptional repression . ^^^ |
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| Interacting proteins: P41182 and Q05516 |
Pubmed |
SVM Score :0.0 |
| Structurally related to BCL 6 , which is involved in human lymphoma , PLZF may have a role in proliferation , differentiation and survival of hematopoietic cells , that could be mediated by transcriptional repression of the cyclin A gene . ^^^ |
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| Interacting proteins: P41182 and Q05516 |
Pubmed |
SVM Score :0.0 |
| Since PLZF , a BCL 6 relative , could also interact with HDAC 4 , 5 , and 7 , we suggest that class 2 HDACs are largely involved in the control of the POK transcription factors activity . . ^^^ |
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| Interacting proteins: P41182 and Q05516 |
Pubmed |
SVM Score :0.0 |
| Glutathione S transferase fusion protein pull down showed that the POZ domains of FBI 1 , Plzf , and Bcl 6 directly interact with the zinc finger DNA binding domain of Sp 1 . ^^^ |
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| Interacting proteins: P41182 and Q05516 |
Pubmed |
SVM Score :0.0 |
| Deregulated function of members of the POK ( POZ and Kruppel ) family of transcriptional repressors , such as promyelocytic leukemia zinc finger ( PLZF ) and B cell lymphoma 6 ( BCL 6 ) , plays a critical role in the pathogenesis of acute promyelocytic leukemia ( APL ) and non Hodgkin ' s lymphoma , respectively . ^^^ |
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| Interacting proteins: P41182 and Q05516 |
Pubmed |
SVM Score :0.0 |
| Bcl 6 , PLZF , HIC 1 ) , endogenous Kaiso localizes predominantly to the nuclei of mammalian cells . ^^^ |
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| Interacting proteins: P41182 and Q05516 |
Pubmed |
SVM Score :0.0 |
| LAZ 3 encodes a transcriptional repressor with a POZ / zinc finger structure similar to several Drosophila development regulators and to the human promyelocytic leukemia associated PLZF gene . ^^^ |
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