| Interacting proteins: P28908 and P41182 |
Pubmed |
SVM Score :0.0 |
| To define the relationship between BCL 6 protein and CD 30 antigen in CD30+ ALCLs and in non neoplastic lymph nodes , serial section immunohistochemistry and two color staining were used in selected CD30+ ALCLs as well as in reactive lymph nodes with non neoplastic T cell proliferations . ^^^ Coexpression of CD 30 and BCL 6 , as detected in CD30+ ALCLs , was also found in a subset of non neoplastic lymphoid elements , namely the large lymphoid cells scattered in the interfollicular areas of reactive lymph nodes . ^^^ |
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| Interacting proteins: P28908 and P41182 |
Pubmed |
SVM Score :0.0 |
| Biopsies were collected from 158 patients with DLBCL and analyzed immunohistochemically for p 53 , p21 / WAF1 , bcl 2 , cyclin D 1 , bcl 6 , mdr , CD 5 , CD 30 , epithelial membrane antigen ( EMA ) , Ki 67 and c myc positive tumor cells . ^^^ |
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| Interacting proteins: P28908 and P41182 |
Pubmed |
SVM Score :0.0 |
| Expression of CD 30 , Bcl 6 and immunoglobulin ( Ig ) was found in 92 % , 31 % and 23 % with EBV ( + ) DLBCL , and in 15 % , 79 % and 82 % with EBV ( ) DLBCL , respectively . ^^^ |
|
| Interacting proteins: P28908 and P41182 |
Pubmed |
SVM Score :0.0 |
| The biopsy samples were studied for histology and for expression of CD 20 , CD 3 , CD 15 , CD 30 , light chains , CD 138 , bcl 6 , epithelial membrane antigen , EBV latent membrane protein 1 , and p 53 protein . ^^^ |
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| Interacting proteins: P28908 and P41182 |
Pubmed |
SVM Score :0.0 |
| The phenotype was CD 20 ( + ) , CD79a ( + ) , CD 10 ( + ) , bcl 6 ( + ) , B cell specific activating protein ( + ) , kappa light chain ( + ) , CD 30 ( / + ) , interferon regulating factor 4 ( / + ) , c myc ( / + ) , lambda light chain ( ) , CD 3 ( ) , bcl 2 ( ) , p 53 ( ) , cytokeratin ( ) , and placental alkaline phosphatase ( ) . ^^^ |
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| Interacting proteins: P28908 and P41182 |
Pubmed |
SVM Score :0.0 |
| Expression greater than that of grade 2 Bcl 6 was observed in 11 of the 30 CD 10 negative cases ( 37 % ) and in all six CD 10 positive cases ( 100 % ; P < 0 . 05 ) without expression of CD 5 , CD 23 , cyclin D 1 , CD 30 or CD 138 . ^^^ |
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| Interacting proteins: P28908 and P41182 |
Pubmed |
SVM Score :0.0 |
| We used a panel of immunohistochemical stains , including those with specificity for germinal center B cells : CD 20 , CD79a , CD 30 , CD 15 , epithelial membrane antigen , BCL 2 , BCL 6 , and CD 10 . ^^^ |
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| Interacting proteins: P28908 and P41182 |
Pubmed |
SVM Score :0.0 |
| METHODS : 60 cases of DLBCL were studied and immunohistochemical staining for LCA , L 26 , BLA 36 , CD 30 , bcl 6 were carried out with the EnVision 2 step method . ^^^ Immunostaining showed 100 % ( 60 / 60 ) DLBCL were positive for LCA , L 26 , BLA 36 , 3 . 3 % ( 2 / 60 ) DLBCL positive for CD 30 , 95 % ( 57 / 60 ) expressed bcl 6 protein . ^^^ |
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| Interacting proteins: P28908 and P41182 |
Pubmed |
SVM Score :0.0 |
| On immunohistochemistry , the following phenotype was observed : CD 45 ( + ) , CD 20 ( + ) , CD79a ( + ) , PAX5 / BSAP ( + ) , BOB . 1 ( + ) , Oct 2 ( + ) , PU . 1 ( + ) , Bcl 2 ( + ) , CD 30 ( + ) , HLA DR ( + ) , MAL protein ( + / ) , Bcl 6 ( + / ) , MUM1 / IRF4 ( + / ) , CD 10 ( / + ) , CD 21 ( ) , CD 15 ( ) , CD 138 ( ) , CD 68 ( ) , and CD 3 ( ) . ^^^ |
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| Interacting proteins: P28908 and P41182 |
Pubmed |
SVM Score :0.0 |
| These cells expressed CD 20 in 98 % ( 59 / 60 ) , CD79a ( usually faint ) in 87 % ( 27 / 31 ) , CD 30 in 7 % ( 4 / 59 ) , epithelial membrane antigen in 21 % ( 12 / 56 ) , bcl 2 in 5 % ( 2 / 41 ) , and bcl 6 in 83 % ( 30 / 36 ) of cases . ^^^ |
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| Interacting proteins: P28908 and P41182 |
Pubmed |
SVM Score :0.0 |
| Clinical features and histology were reviewed and immunohistochemistry was performed for immunoglobulins , CD 20 , CD79a , CD 3 , CD 68 , CD 10 , BCL 6 , BCL 2 , OCT 2 , epithelial membrane antigen , CD 30 , CD 138 , and EBV markers . ^^^ |
|
| Interacting proteins: P28908 and P41182 |
Pubmed |
SVM Score :0.0 |
| The lymphoma cells were composed of medium to large sized cells positive for CD 20 , CD 45 , and BCL 6 , and negative for epithelial cell membrane antigen , CD 30 , CD45RO , and CD138 / syndecan 1 , suggesting a germinal center B cell origin . ^^^ |
|
| Interacting proteins: P28908 and P41182 |
Pubmed |
SVM Score :0.0 |
| The 8 KSHV positive solid lymphomas were virtually indistinguishable from the 29 PELs based on morphology ( immunoblastic / anaplastic ) , immunophenotype ( CD 45 positive ; T cell antigen negative ; CD 30 , EMA , CD 138 positive ; CD 10 , CD 15 , BCL 6 negative ) and genotype ( 100 % immunoglobulin genes rearranged ; no identifiable abnormalities in C MYC , BCL 6 , BCL 1 , BCL 2 ; and uniformly EBV positive ) . ^^^ |
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| Interacting proteins: P28908 and P41182 |
Pubmed |
SVM Score :0.0 |
| TMA were tested with specific antibodies against CD 10 , CD 20 , CD 30 , CD79a , CD 138 , Bcl 2 , Bcl 6 , IRF 4 , and IRTA 1 . ^^^ RESULTS : The following phenotypic subclassification was made : a ) CD 10 + / Bcl 6 + or Bcl 6+ / IRF4 + , but Bcl 2 / CD30 / CD138 suggesting B cells gathering / leaving the germinal center ( group 1 ; n=36 ) ; b ) Bcl 2+ / CD10 / Bcl 6 and CD30+ or CD138+ corresponding to putative non germinal center B cells with features of activation or plasmablastic / plasmacellular differentiation ( group 2 ; n=17 ) ; c ) CD 30 / CD138 with extensive Bcl 2 positivity and variable CD 10 , Bcl 6 and IRF 4 combinations ( group 3 ; n=15 ) . ^^^ |
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| Interacting proteins: P28908 and P41182 |
Pubmed |
SVM Score :0.0 |
| Histological and immunohistochemical analysis of the extradural tumor , which was completely excised , disclosed nodular sclerosis Hodgkin ' s lymphoma with typical Reed Sternberg cells that were positive for CD 30 , CD 15 , bcl 6 , Ki 67 , p 53 , EBV LPM 1 and IgG , and negative for CD 45 , CD 20 , DBA 44 , kappa , lambda light chains and IgM . ^^^ |
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| Interacting proteins: P28908 and P41182 |
Pubmed |
SVM Score :0.0 |
| No expression of anaplastic large cell lymphoma kinase ( ALK ) , CD 10 , CD 23 , CD 30 , CD 43 , bcl 6 , cyclin D 1 , p 53 or p16INK4a could be seen . ^^^ |
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| Interacting proteins: P28908 and P41182 |
Pubmed |
SVM Score :0.0 |
| An immunohistochemical panel consisting of CD 3 , CD 20 , CD 30 , CD 38 , CD45RB , CD79a , CD 138 , Bcl 2 , Bcl 6 , Alk 1 , Ki 67 , EBV LMP 1 , and HHV 8 was performed . ^^^ |
|
| Interacting proteins: P28908 and P41182 |
Pubmed |
SVM Score :0.0 |
| Only 6 patients ( 25 % ) showed CD 30 expression , and Bcl 6 protein expression was , in our series , prognostically favorable ( P = . 0401 ) . ^^^ |
|
| Interacting proteins: P28908 and P41182 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28908 and P41182 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28908 and P41182 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28908 and P41182 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28908 and P41182 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28908 and P41182 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28908 and P41182 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28908 and P41182 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28908 and P41182 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28908 and P41182 |
Pubmed |
SVM Score :0.0 |
| NA |
|