| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| The prototype mitogen activated protein ( MAP ) kinase module is a three kinase cascade consisting of the MAP kinase , extracellular signal regulated protein kinase ( ERK ) 1 or ERK 2 , the MAP / ERK kinase ( MEK ) MEK 1 or MEK 2 , and the MEK kinase , Raf 1 or B Raf . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| Following EGF stimulation of B82L cells expressing a kinase defective EGF receptor mutant ( K721M ) , we found that ERK 2 and ERK 1 MAP kinases , as well as MEK 1 and MEK 2 were all activated , and SHC became prominently tyrosine phosphorylated . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| A constitutively active fragment of rat MEK kinase 1 ( MEKK 1 ) consisting of only its catalytic domain ( MEKK C ) expressed in bacteria quantitatively activates recombinant mitogen activated protein ( MAP ) kinase / extracellular signal regulated protein kinase ( ERK ) kinases 1 and 2 ( MEK 1 and MEK 2 ) in vitro . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| These data demonstrate that the activators of p 38 ( MKK 3 and MKK 4 ) , JNK ( MKK 4 ) , and ERK ( MEK 1 and MEK 2 ) define independent MAP kinase signal transduction pathways . . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| We now demonstrate that three recombinant MEKs ( MEK 1 , MEK 2 , MEK 3 ) show remarkably different activity toward recombinant ERK 1 and ERK 2 . ^^^ MEK 2 is the most active ERK activator . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| Both MEK 1 and MEK 2 were expressed in Escherichia coli and shown to be able to activate recombinant human ERK 1 in vitro . ^^^ The purified MEK 2 protein stimulated threonine and tyrosine phosphorylation on ERK 1 and concomitantly activated ERK 1 kinase activity more than 100 fold . ^^^ The recombinant MEK 2 showed lower activity as an ERK activator as compared with MEK purified from tissue . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| Characterization of ERK 1 activation site mutants and the effect on recognition by MEK 1 and MEK 2 . ^^^ To discern MEK 1 and MEK 2 specificity for their substrate , extracellular signal regulated kinase ( ERK ) , site directed mutagenesis was performed on the amino acid residues flanking the regulatory phosphorylation sites of ERK 1 . ^^^ These ERK 1 mutants were analyzed for the ability to act as a substrate for MEK 1 and MEK 2 . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| The time course and inhibitor sensitivity of MEK 2 activation parallel those of several components of the microbicidal response , suggesting a signaling role of the MEK ERK pathway . . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| MEK 1 and MEK 2 phosphorylate a majority of the ERK 2 mutants . ^^^ Alteration of the residue between the two phosphorylation sites neither dramatically affected the activity of MEK 1 and MEK 2 toward ERK 2 nor conferred recognition by other MEKs . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis was performed using anti ERK 2 , anti MEK 1 , and anti MEK 2 antibodies . ^^^ RESULTS : Corneal tissue expresses ERK 2 or MAPK , and both MEK 1 and MEK 2 , the immediate upstream regulators of MAPK . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| Map / Erk kinase 1 ( MEK 1 ) and MEK 2 activate the Erk / MAP kinases and have been implicated in cell growth and differentiation . ^^^ These findings suggest that MEK 2 may be the primary Erk / MAP kinase activator during development and that MEK 1 may play a role in the proliferative or mitogenic response in adult mouse tissues . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| MAPK expression was determined in five human tumors and five normal tissues ( adjacent non neoplastic liver ) by Western blotting using specific antisera raised against four MAPK pathway intermediates : Erk 1 , Erk 2 ( extracellular signal regulated kinases ) , Mek 1 and Mek 2 ( mitogen activated protein kinase kinases ) . ^^^ There was a significant increase in Erk 1 , Erk 2 , Mek 1 and Mek 2 expression in particulate and cytosolic fractions prepared from tumor specimens as compared with the adjacent normal control tissues . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| Differential regulation of mitogen activated protein / ERK kinase ( MEK ) 1 and MEK 2 and activation by a Ras independent mechanism . ^^^ Mitogen activated protein ( MAP ) / ERK kinase ( MEK ) 1 and MEK 2 are the upstream activators of the MAP kinases , ERK 1 and ERK 2 . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| MEK 2 translocated into membrane in response to insulin may play a role in the activation of the membrane associated ERK 2 via phosphorylation . . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| MEK 1 and MEK 2 contain a proline rich insert not present in any other known MEK ( MAP ( mitogen activated protein ) / ERK ( extracellular signal regulated kinase ) kinase ) family members . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| TPO did not activate the mitogen activated protein kinase / ERK kinases , MEK 1 and MEK 2 , but activated Raf 1 and directly augmented the PKC mediated MEK activation , suggesting that TPO primarily potentiates the ERK pathway through regulating MEKs or upstream steps of MEKs including Raf 1 . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| Cell migration assays indicated that mek 1 / fibroblasts could not be induced to migrate by fibronectin , although the levels of Mek 2 protein and Erk activation were normal . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| Mek 1 and especially Mek 2 protein expression , as well as MAP kinase kinase activity as determined by phosphorylation of kinase inactive Erk [ GST K71A ] were increased in cancer samples . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| In contrast , nuclear extracts from cells exposed to PD 98059 , a highly selective inhibitor of MAP kinase ERK kinase 1 ( MEK 1 ) and MEK 2 , showed reduced binding . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| Whereas wild type p 70 slightly inhibited ERK 2 activation by RAS and MEK 2 , co expression or p 70 DeltaC1 or p 70 DeltaC2 with either protein stimulated ERK 2 cooperatively . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| Co transfection of the FGF BP promoter with dominant negative forms of MEK 2 , extracellular signal regulated kinase 2 , and p 38 significantly decreased the level of EGF induction , whereas expression of a dominant negative c Jun N terminal kinase mutant or expression of c Jun N terminal kinase inhibitory protein had no effect . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| The role of the mitogen activated protein kinase pathway was assessed using PD 98059 , which specifically inhibits mitogen activated protein kinase 1 and 2 ( that is , MEK 1 and MEK 2 ) , which activates mitogen activated protein kinase . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| Here we show that the corresponding sequences in human MEK 1 and MEK 2 are necessary and sufficient for the direct binding of the MAPKs ERK 1 and ERK 2 . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| Inhibition of MAP kinase kinases 1 and 2 ( MEK 1 and MEK 2 , respectively ) , which are upstream from ERK , with the specific MEK inhibitor U 0126 blocked both cell proliferation and ERK activation . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| Surprisingly , MEK 2 but not MEK 1 was the principal mediator of estradiol induced activation of ERK . ^^^ Our data demonstrate the requirement for Hsp 90 in estrogen induced activation of ERK 1 and ERK 2 by MEK 2 in the developing mouse cerebral cortex and also provide insight into alternative mechanisms by which estradiol may influence cytoplasmic and nuclear events in responsive neurons via the MAP kinase cascade . . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| Indeed , MEK 1 and MEK 2 are the only known activators of ERK 1 and ERK 2 . ^^^ Some mutations identified in this manner impaired the two hybrid interaction of ERK 2 with both MEK 1 and MEK 2 , whereas others had a predominant effect on the interaction with either MEK 1 or MEK 2 . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| The lin 45 ( null ) phenotype is similar to the mek 2 ( null ) and mpk 1 ( null ) phenotypes , indicating that LIN 45 , MEK 2 , and MPK 1 ERK MAP kinase function in a predominantly linear signaling pathway . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| Western blot and immunohistochemistry were used to measure the expression of MEK 1 , MEK 2 and ERK 1 , ERK 2 protein . ^^^ RESULTS : MEK 2 and ERK 1 , ERK 2 protein levels were increased in breast carcinoma tissue compared with those in adjacent normal tissues ( t = 7 . 244 , 5 . 959 , 3 . 735 , P < 0 . 01 ) and benign tumors ( t = 2 . 206 , P < 0 . 05 ) . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| Activated forms of Rac and Cdc 42 could enhance the association of wild type ERK 2 with MEK 1 but not with MEK 2 in serum starved adherent cells . ^^^ In detached cells placed in suspension , ERK 2 was complexed with MEK 2 but not with MEK 1 . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| Rather , the decreased GJIC was found to be because of phosphorylation of connexin 43 , the major connexin in the used cell line , which was mediated by MAPK / ERK kinase ( MEK ) 1 and MEK 2 as well as by activation of their direct substrates , extracellular signal regulated kinase ( ERK ) 1 and ERK 2 . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| In the present study , we show that peptides corresponding to the MAPK docking sites of MEK 1 , MEK 2 , Ste 7 , Elk 1 and MAPK phosphatase ( MKP ) 2 potently inhibit MEK 2 phosphorylation of ERK 2 , ERK 2 phosphorylation of Elk 1 , and MKP 1 dephosphorylation of ERK 2 . ^^^ Each peptide inhibited multiple reactions ; for example , the MEK 2 peptide inhibited not only MEK 2 , but also ERK 2 and MKP 1 . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| Finally , the selectivity of the MKK 4 , MEK 1 , and MEK 2 D sites for JNK versus ERK was quantified . ^^^ The MEK 1 and MEK 2 D sites displayed a strong selectivity for their cognate MAPK ( ERK 2 ) versus a non cognate MAPK ( JNK ) . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| Although several components of the ERK / MAP kinase cascade have been implicated in thymocyte development , no such involvement was observed for MEK 2 , which appears to be nonessential for thymocyte differentiation and T cell receptor induced proliferation and apoptosis . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| However , the reversibility of these cellular events , as well as the relative role of both MEK isoforms ( MEK 1 and MEK 2 ) and both ERK isoforms ( ERK 1 and ERK 2 ) during these processes , has not yet been investigated . ^^^ We now report that loss of constitutively active MEK 1 ( caMEK 1 ) and , thus , loss of active ERK1 / 2 in C7caMEK1 cells is associated with increased MEK 2 protein expression , reexpression of ERK 1 protein , and epithelial redifferentiation of these cells . ^^^ In these clones , increased MEK1 / 2 ERK1 / 2 phosphorylation , reduced MEK 2 protein expression , and loss of ERK 1 protein expression is associated with phenotypic alterations similar to those observed in transdifferentiated C7caMEK1 cells . ^^^ We conclude that in renal epithelial MDCK C 7 cells , stable epithelial to mesenchymal transition ( EMT ) is associated with loss of ERK 1 protein expression , reduced MEK 2 protein expression , and increased basal ERK 2 phosphorylation . ^^^ In contrast , loss of active MEK 1 ERK1 / 2 results in increased MEK 2 protein expression and reexpression of ERK 1 protein , concomitant with the restoration of epithelial phenotype and the ability to form cystic structures . . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| Among the KRAS2 / BRAF wild type carcinomas , no mutations within pathway members MEK 1 , MEK 2 , ERK 1 , ERK 2 , RAP1B , or BAD were found . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| Using in vitro assays , we show that platelet derived growth factor alpha ( PDGFA ) enhances medulloblastoma migration and increases downstream MAP2K1 ( MEK 1 ) , MAP2K2 ( MEK 2 ) , MAPK 1 ( p 42 MAPK ) and MAPK 3 ( p 44 MAPK ) phosphorylation in a dose dependent manner . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| Mek 1 and Erk 1 depletion also caused cell cycle arrest at G 2 , suggesting that these enzymes are required for the G2 / M transition , whereas the loss of Mek 2 or Erk 2 caused arrest at G1 . . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| We now show that in double positive thymocytes Vav 1 is required for TCR induced activation of the ERK 1 and ERK 2 kinases via a pathway involving the Ras GTPase , and B Raf , MEK 1 , and MEK 2 kinases . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| The activation of the protein kinases Raf 1 , MEK 2 , and ERK 2 is essential for this form of nonapoptotic pcd , leading to the phosphorylation of the orphan nuclear receptor Nur 77 . ^^^ NK ( 1 ) R mediated cell death was inhibited by a dominant negative form of arrestin 2 , Raf 1 , or Nur 77 , by MEK1 / 2 specific inhibitors , and by RNA interference directed against ERK 2 or MEK 2 but not ERK 1 or MEK 1 and against Nur 77 . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| METHODS : In the present study , we examined expression of PKCbeta 1 , MAPK / ERK kinase ( MEK ) 1 , MEK 2 , extracellular signal regulated protein kinase ( ERK ) 1 , ERK 2 , and TGF beta 1 mRNAs using renal tissue samples from kidneys affected by DN ( N= 21 ) and from normal human kidney ( NHK ; N= 6 ) . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| The highly homologous kinases , Mek 1 and Mek 2 , act downstream of Ras and Raf to activate extracellular signal regulated kinase ( ERK ) mitogen activated protein kinases . ^^^ Both Mek 1 and Mek 2 triggered ERK phosphorylation . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| The role of the extracellular signal regulated kinase ( ERK ) 1 and ERK 2 in the neutrophil chemotactic response remains to be identified since a previously used specific inhibitor of MEK 1 and MEK 2 , PD 98059 , that was used to provide evidence for a role of ERK 1 and ERK 2 in regulating chemotaxis , has recently been reported to also inhibit MEK 5 . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| In our previous investigations , mitogen activated protein kinase kinase 2 ( MEK 2 ) / extracellular signal regulated kinase 2 ( ERK 2 ) signaling pathway was found to be correlated with the cell dissociation induced by dissociation factor ( DF ) in pancreatic cancer cells . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| Here we found that the ability of constitutively active human MEK 1 and MEK 2 to stimulate ERK phosphorylation and to induce the neoplastic transformation of NIH 3T3 cells required the integrity of the D site . ^^^ ERK activation , cytoplasmic anchoring and release were completely retained in ' swap ' mutants in which MEK 2 ' s D site was replaced with the D site of MEK 1 or yeast Ste 7 . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| We found that Vpr expression is associated with the down regulation of genes in the MEK 2 ERK pathway and with decreased phosphorylation of the MEK 2 effector protein ERK . ^^^ Exogenous provision of excess MEK 2 reverses the cell cycle arrest associated with Vpr , confirming the involvement of the MEK 2 ERK pathway in Vpr mediated cell cycle arrest . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| In this study , the expression of ZO 1 and a downstream kinase of MEK 2 , extracellular signal regulated kinase 2 ( ERK 2 ) , was analyzed to clarify the regulatory mechanism of cell dissociation in pancreatic cancer cells . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| The addition of ERK 2 enhanced by fourfold the in vitro interaction of MEK 2 with IQGAP 1 without altering binding of MEK 1 . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| Similar conformational changes occur in a complex between ERK 2 and a MEK 2 ( MAP / ERK kinase 2 ) derived D motif peptide ( pepMEK 2 ) . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| Dominant negative MEK 1 , MEK 2 , and ERK 2 block PPARgamma induced EMT , whereas constitutively active MEK 1 and MEK 2 induce a mesenchymal phenotype similar to that evoked by PPARgamma . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| The MPM 2 phosphoepitope can be generated in vitro on bacterially expressed p42mapk by phosphorylation with either isoform of MAP kinase kinase ( MKK ) , MKK 1 , or MKK 2 . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| Mitogen activated protein ( MAP ) kinase kinases ( MKKs ) are dual specificity protein kinases which activate p42mapk and p44mapk by phosphorylation of regulatory tyrosine and threonine residues . cDNAs for two isotypes of MKK , MKK 1 and MKK 2 , have been isolated from several species . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| Both cDNAs when expressed in COS cells displayed the ability to phosphorylate and activate p42mapk and p44mapk , both MKK 1 and MKK 2 were activated in vivo in response to serum , and both could be phosphorylated and activated by the 5 Raf protein in vitro . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| Transformation of immortalized rat embryo fibroblasts by a ts isolate of Moloney murine sarcoma virus ( Mo MuSVts 110 ) constitutively activates MAP kinases ( ERK 1 and ERK 2 ) and MAP kinase kinases ( MKK 1 and MKK 2 ) only at the permissive temperature when 5 mos kinase is present and active . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| The mitogen activated protein ( MAP ) kinase pathway , which includes extracellular signal regulated protein kinases 1 and 2 ( ERK 1 , ERK 2 ) and MAP kinase kinases 1 and 2 ( MKK 1 , MKK 2 ) , is well known to be required for cell cycle progression from G 1 to S phase , but its role in somatic cell mitosis has not been clearly established . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| PD 98059 , an inhibitor of ERK upstream activators MAPK kinase ( MKK ) 1 and MKK 2 , greatly enhanced cytotoxicity and apoptosis in cells treated with low Cd doses . ^^^ |
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| Interacting proteins: P36507 and P28482 |
Pubmed |
SVM Score :0.0 |
| The C terminal region of mitogen activated protein kinase kinase 1 and 2 ( MKK 1 and MKK 2 ) may function in regulating interactions with upstream kinases or the magnitude and duration of ERK mitogen activated protein kinase activity . ^^^ |
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