| Interacting proteins: P36507 and P15056 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P36507 and P15056 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P36507 and P15056 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P36507 and P15056 |
Pubmed |
SVM Score :0.0 |
| The prototype mitogen activated protein ( MAP ) kinase module is a three kinase cascade consisting of the MAP kinase , extracellular signal regulated protein kinase ( ERK ) 1 or ERK 2 , the MAP / ERK kinase ( MEK ) MEK 1 or MEK 2 , and the MEK kinase , Raf 1 or B Raf . ^^^ |
|
| Interacting proteins: P36507 and P15056 |
Pubmed |
SVM Score :0.0 |
| The first MEK activator has an apparent M ( r ) of 40 , 000 50 , 000 , was immunologically distinct from A Raf , B Raf , c Raf 1 , c MEKK , c Mos , MEK 1 , and MEK 2 , and was rapidly activated by serum , platelet derived growth factor ( PDGF ) , insulin , thrombin , and phorbol ester . ^^^ |
|
| Interacting proteins: P36507 and P15056 |
Pubmed |
SVM Score :0.0 |
| Receptor induced activation of other Ser / Thr kinases , such as c Raf , B Raf , Mek 1 , Mek 2 , Mekk , was not affected by wortmannin . ^^^ |
|
| Interacting proteins: P36507 and P15056 |
Pubmed |
SVM Score :0.0 |
| We show that , consequently , B Raf interacts with MEK 1 and MEK 2 with a better affinity than does c Raf 1 , thus strengthening the notion that B Raf is a stronger MEK activator than c Raf l . ^^^ |
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| Interacting proteins: P36507 and P15056 |
Pubmed |
SVM Score :0.0 |
| RESULTS : In the yeast two hybrid interaction assay , mKsr 1 did not bind to either Ras , B Raf or Raf 1 , but interacted strongly with both MEK 1 and MEK 2 , activators of MAP kinase . ^^^ |
|
| Interacting proteins: P36507 and P15056 |
Pubmed |
SVM Score :0.0 |
| Among the KRAS2 / BRAF wild type carcinomas , no mutations within pathway members MEK 1 , MEK 2 , ERK 1 , ERK 2 , RAP1B , or BAD were found . ^^^ |
|
| Interacting proteins: P36507 and P15056 |
Pubmed |
SVM Score :0.0 |
| Furthermore , three of five individuals without BRAF mutations had missense mutations in either MEK 1 or MEK 2 , downstream effectors of B Raf . ^^^ |
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