Pubmed abstracts for Protein-Protein Interaction search result :


Interacting proteins: P36507 and P04049 Pubmed SVM Score :0.0
PDGF BB also activated MAPK kinase 2 ( MAPKK 2 ) but had no effect on MAPKK 1 and Raf 1 activity . ^^^
Interacting proteins: P36507 and P04049 Pubmed SVM Score :0.0
Interestingly , A Raf does not activate MEK 2 , although c Raf can activate both MEK 1 and MEK 2 . ^^^
Interacting proteins: P36507 and P04049 Pubmed SVM Score :0.0
Subsequently , the kinase cascade ( Raf 1 , Mek 2 , and p44MAPK [ mitogen activated protein kinase ] ) is activated . ^^^
Interacting proteins: P36507 and P04049 Pubmed SVM Score :0.0
In addition , neither Mek 1 nor Mek 2 are stably activated in coordination with Raf 1 in nocodazole arrested cells . ^^^
Interacting proteins: P36507 and P04049 Pubmed SVM Score :0.0
These changes regulate the ability of Raf 1 to phosphorylate its downstream targets MEK 1 and MEK 2 . ^^^
Interacting proteins: P36507 and P04049 Pubmed SVM Score :0.0
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Interacting proteins: P36507 and P04049 Pubmed SVM Score :0.0
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Interacting proteins: P36507 and P04049 Pubmed SVM Score :0.0
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Interacting proteins: P36507 and P04049 Pubmed SVM Score :0.0
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Interacting proteins: P36507 and P04049 Pubmed SVM Score :0.0
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Interacting proteins: P36507 and P04049 Pubmed SVM Score :0.0
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Interacting proteins: P36507 and P04049 Pubmed SVM Score :0.0
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Interacting proteins: P36507 and P04049 Pubmed SVM Score :0.0
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Interacting proteins: P36507 and P04049 Pubmed SVM Score :0.0
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Interacting proteins: P36507 and P04049 Pubmed SVM Score :0.0
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Interacting proteins: P36507 and P04049 Pubmed SVM Score :0.0
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Interacting proteins: P36507 and P04049 Pubmed SVM Score :0.0
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Interacting proteins: P36507 and P04049 Pubmed SVM Score :0.0
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Interacting proteins: P36507 and P04049 Pubmed SVM Score :0.0
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Interacting proteins: P36507 and P04049 Pubmed SVM Score :0.0
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Interacting proteins: P36507 and P04049 Pubmed SVM Score :0.0
The prototype mitogen activated protein ( MAP ) kinase module is a three kinase cascade consisting of the MAP kinase , extracellular signal regulated protein kinase ( ERK ) 1 or ERK 2 , the MAP / ERK kinase ( MEK ) MEK 1 or MEK 2 , and the MEK kinase , Raf 1 or B Raf . ^^^
Interacting proteins: P36507 and P04049 Pubmed SVM Score :0.0
RAS and RAF 1 form a signalling complex with MEK 1 but not MEK 2 . ^^^ Consistent with the preferential binding of MEK 1 to RAS : RAF 1 , the basal activity of MEK 1 in 5 ras transformed cells was found to be elevated sixfold , whereas MEK 2 was elevated only twofold , suggesting that the RAS signalling pathway favors MEK 1 activation . . ^^^
Interacting proteins: P36507 and P04049 Pubmed SVM Score :0.0
Receptor induced activation of other Ser / Thr kinases , such as c Raf , B Raf , Mek 1 , Mek 2 , Mekk , was not affected by wortmannin . ^^^
Interacting proteins: P36507 and P04049 Pubmed SVM Score :0.0
RESULTS : In the yeast two hybrid interaction assay , mKsr 1 did not bind to either Ras , B Raf or Raf 1 , but interacted strongly with both MEK 1 and MEK 2 , activators of MAP kinase . ^^^
Interacting proteins: P36507 and P04049 Pubmed SVM Score :0.0
TPO did not activate the mitogen activated protein kinase / ERK kinases , MEK 1 and MEK 2 , but activated Raf 1 and directly augmented the PKC mediated MEK activation , suggesting that TPO primarily potentiates the ERK pathway through regulating MEKs or upstream steps of MEKs including Raf 1 . ^^^
Interacting proteins: P36507 and P04049 Pubmed SVM Score :0.0
Using MEK 2 as bait in yeast two hybrid screening , besides c Raf and KSR , A Raf was identified as a novel partner that interacts with MEK 2 . ^^^
Interacting proteins: P36507 and P04049 Pubmed SVM Score :0.0
These data indicate that the signaling of 2B4 in NK cells is mediated by GSK 3 and beta catenin , possibly through a signal transduction pathway that involves Vav 1 , Rac 1 , Raf 1 , MEK 2 , and Erk1 / 2 and that this pathway is aberrant in individuals with XLP . . ^^^
Interacting proteins: P36507 and P04049 Pubmed SVM Score :0.0
Co infection of Sf 9 cells with either MKK 1 or MKK 2 virus together with recombinant viruses for Raf 1 , pp60src ( Y527F ) and c Ha Ras resulted in activations of 250 fold and 150 fold for MKK 1 and MKK 2 respectively . ^^^
Interacting proteins: P36507 and P04049 Pubmed SVM Score :0.0
Raf 1 , a direct regulator of MKK 1 and MKK 2 , was activated under these conditions , and a synergistic activation of MKK was observed upon coexpression of Raf 1 and MKP 1 . ^^^