| Interacting proteins: Q9UQC2 and P31749 |
Pubmed |
SVM Score :0.93675768 |
| This represents phosphorylation by the serine / threonine kinase protein kinase B ( PKB ) , since PKB constitutively associates with Gab 2 , phosphorylates Gab 2 on a consensus phosphorylation site , Ser 159 , in vitro and inhibits Gab 2 tyrosine phosphorylation . 0.93675768^^^ |
|
| Interacting proteins: Q9UQC2 and P31749 |
Pubmed |
SVM Score :0.0 |
| We identify the adaptor protein Grb 2 associated binder 2 ( Gab 2 ) as a direct E2F target gene and an essential effector of E2F dependent AKT activation . ^^^ |
|
| Interacting proteins: Q9UQC2 and P31749 |
Pubmed |
SVM Score :0.0 |
| Here we report that the molecular adapter Grb 2 associated binder 2 ( Gab 2 ) associates with RANK and mediates RANK induced activation of NF kappaB , Akt and Jnk . ^^^ |
|
| Interacting proteins: Q9UQC2 and P31749 |
Pubmed |
SVM Score :0.0 |
| The majority of cytokine stimulated PI 3K activity associates with Gab 2 , and inducible expression of a Gab 2 mutant unable to bind PI 3K markedly impairs IL 3 induced Akt activation and cell growth . ^^^ |
|
| Interacting proteins: Q9UQC2 and P31749 |
Pubmed |
SVM Score :0.0 |
| KitL induced ERK MAP kinase and Akt activation were impaired in Gab 2 deficient BMMCs . ^^^ |
|
| Interacting proteins: Q9UQC2 and P31749 |
Pubmed |
SVM Score :0.0 |
| Downstream events such as calcium mobilization , degranulation , and induction of TNF alpha and IL 6 gene transcripts were decreased in Gab 2 overexpressing cells , although Akt phosphorylation as a measure of PI 3 kinase activation was unaffected . ^^^ |
|
| Interacting proteins: Q9UQC2 and P31749 |
Pubmed |
SVM Score :0.0 |
| Furthermore , PP 1 blocks Gab 2 associated downstream events including EGF induced PI 3 kinase activation , Akt phosphorylation , and DNA synthesis . ^^^ Mutation of the proline rich sequences in Gab 2 prevented EGF induced Gab 2 phosphorylation , PI 3 kinase / Akt activation , and DNA synthesis , demonstrating that Gab 2 phosphorylation is critical for EGF induced mitogenesis and is not complemented by ErbB 3 or Shc phosphorylation . ^^^ |
|
| Interacting proteins: Q9UQC2 and P31749 |
Pubmed |
SVM Score :0.0 |
| We propose that Gab 1 and Gab 2 in cooperation with other adapter molecules might regulate the cellular localization of GC GAP under specific stimuli , acting to regulate precisely Rac and Cdc 42 activities . ^^^ |
|
| Interacting proteins: Q9UQC2 and P31749 |
Pubmed |
SVM Score :0.0 |
| G CSF induced tyrosine phosphorylation of Gab 2 is Lyn kinase dependent and associated with enhanced Akt and differentiative , not proliferative , responses . ^^^ Levels of phospho Akt and phospho extracellular signal regulated kinase ( phospho ERK ) were greater in proximal truncated than in wild type G CSFR cells , suggesting that Gab 2 is dissociated from PI 3 kinase or ERK activities . ^^^ Overexpression of Gab 2 enhanced the phosphorylation state of Akt , but not of ERK . ^^^ All together , these data indicate that G CSF treatment leads to Lyn mediated tyrosine phosphorylation of Gab 2 , which may serve as an important intermediate of enhanced Akt activity and myeloid differentiation , not growth / survival response . . ^^^ |
|
| Interacting proteins: Q9UQC2 and P31749 |
Pubmed |
SVM Score :0.0 |
| Biochemical analysis reveals that the complementary signaling pathway through Gab 2 and Akt is inhibited by this compound in mast cells . ^^^ |
|
| Interacting proteins: Q9UQC2 and P31749 |
Pubmed |
SVM Score :0.0 |
| A Tel Abl point mutant ( Y314F ) and a splice variant without TEL exon 5 sequences ( Deltae 5 ) lacked Grb 2 interaction and exhibited decreased binding and phosphorylation of the scaffolding protein Gab 2 and impaired activation of phosphatidylinositol 3 kinase , Akt , and extracellular signal regulated kinase / mitogen activated protein kinase in hematopoietic cells . ^^^ |
|
| Interacting proteins: Q9UQC2 and P31749 |
Pubmed |
SVM Score :0.0 |
| Transformation requires multiple domains within Shp 2 and the Shp 2 binding protein Gab 2 , and is associated with hyperactivation of the Erk , Akt , and Stat 5 pathways . ^^^ |
|
| Interacting proteins: Q9UQC2 and P31749 |
Pubmed |
SVM Score :0.0 |
| The phosphorylation of Gab 2 , Akt and Vav was also inhibited by WHI P 131 and WHI P 154 , indicating that these inhibitors suppress the activation of phosphatidylinositol 3 kinase ( PI3K ) . ^^^ |
|
| Interacting proteins: Q9UQC2 and P31749 |
Pubmed |
SVM Score :0.0 |
| Gab 2 suppression reduces bFGF dependent activation of AKT but not ERK , and constitutively active AKT , but not constitutively active MEK 1 , reverses the hypersensitization . ^^^ Thus , Gab 2 mediated AKT activation is required for bFGF ' s protection . ^^^ Our findings provide the first evidence that Gab 2 is an important player in neural differentiation , partly by acting downstream of bFGF to mediate survival through phosphoinositide 3 kinase AKT . . ^^^ |
|
| Interacting proteins: Q9UQC2 and P31749 |
Pubmed |
SVM Score :0.0 |
| In addition , binding of Shc , c Cbl , and Gab 2 , but not Crk L , to p85mut was abrogated . p85mut diminished BCR / ABL dependent activation of PI 3k and Akt kinase , the downstream effector of PI 3k . ^^^ |
|
| Interacting proteins: Q9UQC2 and P31749 |
Pubmed |
SVM Score :0.0 |
| In monolayer culture , expression of Gab 2 at levels comparable with those detected in human breast cancer cells accelerated epidermal growth factor ( EGF ) induced cell cycle progression and was associated with increased basal Stat 5 tyrosine phosphorylation and enhanced and / or more sustained EGF induced Erk and Akt activation . ^^^ |
|
| Interacting proteins: Q9UQC2 and P31749 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the Grb 2 SH3 binding sites and PH domain binding to PI3K lipid products are required for Gab 2 function in FcepsilonRI evoked degranulation and Akt activation . ^^^ |
|
| Interacting proteins: Q9UQC2 and P31749 |
Pubmed |
SVM Score :0.0 |
| Treatment of CML cell lines and mouse Bcr Abl+ 32D cells with either Jak 2 short interfering RNA or Jak 2 kinase inhibitor AG 490 inhibited pTyr Gab 2 and pSer Akt formation , inhibited the activation of nuclear factor kappaB , and caused the activation of GSK 3beta , leading to the reduction of c Myc . ^^^ |
|
| Interacting proteins: Q9UQC2 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQC2 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQC2 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQC2 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQC2 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQC2 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQC2 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQC2 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQC2 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQC2 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQC2 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQC2 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQC2 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|