| Interacting proteins: Q9UKG1 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UKG1 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UKG1 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UKG1 and P31749 |
Pubmed |
SVM Score :0.0 |
| APPL suppresses androgen receptor transactivation via potentiating Akt activity . ^^^ APPL may function as an adapter protein to modulate the phosphatidylinositol 3 kinase ( PI3K ) / Akt pathway . ^^^ Although we have previously proven that the PI3K / Akt pathway can suppress androgen receptor ( AR ) transactivation , the potential linkage from APPL to the AR remains unclear . ^^^ This suppressive effect could be blocked by either dominant negative Akt or dominant negative PI3K or LY 294002 , suggesting that the APPL mediated suppression of AR transactivation is dependent on the PI3K / Akt pathway . ^^^ We also observed that APPL could further enhance the Akt mediated suppression of AR transactivation and AR target gene using the reporter gene and Northern blot assay . ^^^ |
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