| Interacting proteins: Q9UIW2 and P31749 |
Pubmed |
SVM Score :0.0 |
| The activity of the plexin A 1 receptor is regulated by Rac . ^^^ Sema3A / Plexin A 1 induced growth cone collapse , for example , requires Rac activity , which is a surprising result given that this GTPase is usually associated with membrane protrusions . ^^^ We show here that Sema3A induced collapse of COS 7 cells expressing Plexin A 1 also requires Rac but not Rho activity and that the cytoplasmic tail of Plexin A 1 interacts directly with activated Rac . ^^^ However , collapse induced by a constitutively activated version of Plexin A 1 does not require Rac . ^^^ We propose a novel function for Rac , namely that it acts upstream of Plexin A 1 during semaphoring induced collapse , to regulate the activity of the receptor . . ^^^ |
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| Interacting proteins: Q9UIW2 and P31749 |
Pubmed |
SVM Score :0.0 |
| Sema3A binding to neuropilin 1 induces the dissociation of FARP 2 from plexin A 1 , resulting in activation of FARP 2 ' s Rac GEF activity , Rnd 1 recruitment to plexin A 1 , and downregulation of R Ras . ^^^ |
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| Interacting proteins: Q9UIW2 and P31749 |
Pubmed |
SVM Score :0.0 |
| Plexin A 1 also induced dephosphorylation of Akt and GSK 3beta through its R Ras GAP activity . ^^^ |
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| Interacting proteins: Q9UIW2 and P31749 |
Pubmed |
SVM Score :0.0 |
| Reducing plexin A 1 expression with shRNA greatly reduced actin polarization as well as Rho activation without affecting Rac or Cdc 42 activation . ^^^ |
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| Interacting proteins: Q9UIW2 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
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