| Interacting proteins: Q99683 and P31749 |
Pubmed |
SVM Score :0.50617419 |
| An association between Akt and ASK 1 was detected in cells by coimmunoprecipitation . 0.50617419^^^ |
|
| Interacting proteins: Q99683 and P31749 |
Pubmed |
SVM Score :0.91575302 |
| The N terminal domain of ASK 1 containing the Akt phosphorylation site ( pSer 83 ) associates with Akt in resting state . 0.91575302^^^ |
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| Interacting proteins: Q99683 and P31749 |
Pubmed |
SVM Score :0.55697812 |
| Dissociated Akt 1 binds to SEK 1 and ASK 1 and inhibits their enzyme activity by phosphorylating SEK 1 on the Ser 80 residue and ASK 1 on the Ser 83 residue . 0.55697812^^^ |
|
| Interacting proteins: Q99683 and P31749 |
Pubmed |
SVM Score :0.0 |
| It was found that physiological concentration of selenite , 3 microM , reduced ASK 1 activity and induced PI 3 kinase ( PI 3 K ) / Akt pathways in HT 1080 cells . ^^^ Selenite blocked apoptosis induced by H2O2 , which was related to blocking ASK 1 and further stimulating PI 3 kinase / Akt activities . ^^^ |
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| Interacting proteins: Q99683 and P31749 |
Pubmed |
SVM Score :0.0 |
| Antioxidants such as selenium block apoptosis induced by ROS through blocking apoptotic signal ASK 1 and stimulating survival signal Akt activity . ^^^ |
|
| Interacting proteins: Q99683 and P31749 |
Pubmed |
SVM Score :0.0 |
| Also , inactivation of Akt by either a specific inhibitor or a genetic knockout of Akt 1 results in p 38 activation , possibly through the release of the activity of p 38 upstream kinases , including ASK 1 and MEKK 3 . ^^^ |
|
| Interacting proteins: Q99683 and P31749 |
Pubmed |
SVM Score :0.0 |
| Akt and apoptosis signal regulating kinase 1 ( ASK 1 ) were physically associated , and E 2 induced the phosphorylation of ASK 1 at serine 83 , which is a consensus Akt phosphorylation site . ^^^ These results indicate that E 2 inhibits paclitaxel induced cell damage by inhibiting JNK activity via phosphorylation of Akt ASK 1 . ^^^ |
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| Interacting proteins: Q99683 and P31749 |
Pubmed |
SVM Score :0.0 |
| Indeed , the increase in AKT activation after isolation correlated with suppression of apoptosis signal regulating kinase 1 ( ASK 1 ) , a kinase acting upstream of JNK , by phosphorylation at Ser 83 . ^^^ |
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| Interacting proteins: Q99683 and P31749 |
Pubmed |
SVM Score :0.0 |
| Akt / protein kinase B is a major cell survival pathway through phosphorylation of proapoptotic proteins Bad and Bax and of additional apoptotic pathways linked to Forkhead proteins glycogen synthase kinase 3beta and ASK 1 . ^^^ |
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| Interacting proteins: Q99683 and P31749 |
Pubmed |
SVM Score :0.0 |
| To further examine the role of JNK / SAPK signaling cascades in apoptosis resulting from microtubular dysfunction induced by paclitaxel , we have coexpressed dominant negative ( dn ) mutants of signaling proteins of the JNK / SAPK pathway ( Ras , ASK 1 , Rac , JNKK , and JNK ) in human ovarian cancer cells with a selectable marker to analyze the apoptotic characteristics of cells expressing dn vectors following exposure to paclitaxel . ^^^ |
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| Interacting proteins: Q99683 and P31749 |
Pubmed |
SVM Score :0.0 |
| Dissociation of Akt 1 from its negative regulator JIP 1 is mediated through the ASK 1 MEK JNK signal transduction pathway during metabolic oxidative stress : a negative feedback loop . ^^^ |
|
| Interacting proteins: Q99683 and P31749 |
Pubmed |
SVM Score :0.0 |
| Furthermore , AKT phosphorylation of apoptosis signal regulating kinase 1 ( ASK 1 ) on Ser 83 was reduced by DPI and siNox4RNAs . ^^^ When ASK1Ser83Ala ( an AKT phosphorylation defective ASK 1 mutant ) was introduced into PANC 1 cells , this mutant alone induced apoptosis . ^^^ Taken together , these findings suggest that ROS generated by Nox 4 , at least in part , transmit cell survival signals through the AKT ASK 1 pathway in pancreatic cancer cells and their depletion leads to apoptosis . . ^^^ |
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| Interacting proteins: Q99683 and P31749 |
Pubmed |
SVM Score :0.0 |
| TNF alpha significantly activated ASK 1 , increased serine phosphorylation of insulin receptor substrate ( IRS ) 1 , and decreased insulin stimulated tyrosine phosphorylation of IRS 1 and serine phosphorylation of Akt , and all of these effects were inhibited by overexpression of either UCP 1 or MnSOD . ^^^ |
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| Interacting proteins: Q99683 and P31749 |
Pubmed |
SVM Score :0.0 |
| Down regulation of PTEN by sodium orthovanadate inhibits ASK 1 activation via PI 3 K / Akt during cerebral ischemia in rat hippocampus . ^^^ In this study , we examined the phosphorylation of ASK 1 , Akt and PTEN and the effects of sodium orthovanadate on these signal proteins during ischemia . ^^^ The following results were observed : ( 1 ) the decreased tyrosine phosphorylation of PTEN and the decreased serine phosphorylation of Akt induced by ischemia were suppressed by sodium orthovanadate , respectively . ( 2 ) The phosphorylation of ASK 1 at serine 83 was decreased and the phosphorylation of ASK 1 at threonine 845 was increased during ischemia . ^^^ However , LY 294002 could reverse the effect of sodium orthovanadate on the phosphorylation of ASK 1 at threonine 845 , namely , sodium orthovanadate inhibited ASK 1 through the PI 3 K / Akt dependent pathway . ^^^ Taken together , we concluded that sodium orthovanadate could increase the tyrosine posphorylation of PTEN and further inhibit the activation of ASK 1 via activating Akt during cerebral ischemia . . ^^^ |
|
| Interacting proteins: Q99683 and P31749 |
Pubmed |
SVM Score :0.0 |
| This applies to tumor suppressors of the Bax / Bcl 2 family ( Bax , Bad , Bid , Bim ) , several protein kinases ( Akt , ASK 1 , hexokinase ) , p 53 , NF kappaB , and nuclear orphan receptors such as TR3 / Nur77 . ^^^ |
|
| Interacting proteins: Q99683 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99683 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99683 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99683 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99683 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|