| Interacting proteins: Q92731 and P31749 |
Pubmed |
SVM Score :0.57246201 |
| For instance we have provided , for the first time , a different interaction of the two ERs with the PI3K / Akt pathway , because ER alpha interacts with the p 55 regulatory subunit of PI3K , whereas ER beta interacts with Akt 1 . 0.57246201^^^ |
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| Interacting proteins: Q92731 and P31749 |
Pubmed |
SVM Score :0.0 |
| We further examined the 17beta E 2 induced Akt activity in Chinese hamster ovary ( CHO ) cells transiently transfected with cDNAs for estrogen receptor alpha ( ERalpha ) or estrogen receptor beta ( ERbeta ) . 17beta E 2 stimulated the activation of Akt in CHO cells expressing ERalpha but not in CHO cells expressing ERbeta . ^^^ |
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| Interacting proteins: Q92731 and P31749 |
Pubmed |
SVM Score :0.0 |
| Moreover , raloxifene stimulated the activation of Akt , ERK , and eNOS in Chinese hamster ovary cells expressing estrogen receptor alpha but not Chinese hamster ovary cells expressing estrogen receptor beta . ^^^ |
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| Interacting proteins: Q92731 and P31749 |
Pubmed |
SVM Score :0.0 |
| Here we report that the proliferative response of UIII rat uterine stromal cells to a short treatment with progestins requires active progesterone receptor ( PR ) and estrogen receptor beta ( ERbeta ) as well as a rapid and transient activation of Erk 1 2 and Akt signaling . ^^^ |
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| Interacting proteins: Q92731 and P31749 |
Pubmed |
SVM Score :0.0 |
| Expression and activation of Akt proteins , nuclear [ 3H ] estradiol binding , and the expression of estrogen receptor alpha ( ERalpha ) and beta ( ERbeta ) and of progesterone receptor ( PR ) were investigated . ^^^ |
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| Interacting proteins: Q92731 and P31749 |
Pubmed |
SVM Score :0.0 |
| Concomitantly , a variety of oncogenic changes ( H ras , erb B 2 , etc . ) may result in the constitutive activation of MAPK and PI 3 ' K / AKT signaling cascades , which , in turn , can activate SREBP 1c and , subsequently , tumor associated FAS catalyzed endogenous lipogenesis . ^^^ |
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| Interacting proteins: Q92731 and P31749 |
Pubmed |
SVM Score :0.0 |
| In the present study , we demonstrated that E 2 protected cardiac H9c2 cells , expressing ERbeta from H2O2 induced apoptosis concomitant with an increase in the activity of Akt . ^^^ Inhibitors for both gamma glutamylcysteine synthetase and GRX and ICI 182 , 780 , a specific inhibitor of ERs , abolished the protective effect of E 2 on cell survival as well as the activity of Akt , suggesting that ERbeta is involved in the cytoprotection and redox regulation by E 2 . ^^^ These results suggest that the GRX / GSH system is involved in the cytoprotective and genomic effects of E 2 on the redox state of Akt , a pathway that is mediated , at least in part , by ERbeta . ^^^ |
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| Interacting proteins: Q92731 and P31749 |
Pubmed |
SVM Score :0.0 |
| Rapid phosphorylation of ERK1 / 2 , protein kinase B / Akt , and eNOS serine 1177 by equol was paralleled by association of eNOS with heat shock protein 90 ( Hsp 90 ) and NO synthesis in human umbilical vein endothelial cells , expressing estrogen receptors ( ER ) alpha and ERbeta . ^^^ |
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| Interacting proteins: Q92731 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92731 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92731 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92731 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92731 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92731 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92731 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92731 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92731 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|