| Interacting proteins: Q16584 and P31749 |
Pubmed |
SVM Score :0.7849002 |
| Using yeast two hybrid analysis and in vitro dot blots , we show that MLK 2 and MLK 3 interact with the activated ( GTP bound ) forms of Rac and Cdc 42 , with a slight preference for Rac . 0.7849002^^^ |
|
| Interacting proteins: Q16584 and P31749 |
Pubmed |
SVM Score :0.0 |
| K252a and CEP 1347 are neuroprotective compounds that inhibit mixed lineage kinase 3 and induce activation of Akt and ERK . ^^^ |
|
| Interacting proteins: Q16584 and P31749 |
Pubmed |
SVM Score :0.0 |
| Negative regulation of mixed lineage kinase 3 by protein kinase B / AKT leads to cell survival . ^^^ |
|
| Interacting proteins: Q16584 and P31749 |
Pubmed |
SVM Score :0.0 |
| Signaling through the small G protein Rac and mixed lineage kinase 3 ( MLK 3 ) resulted in increased phosphorylation of golgin 160 . ^^^ |
|
| Interacting proteins: Q16584 and P31749 |
Pubmed |
SVM Score :0.0 |
| In our present results , ischemic preconditioning could not only inhibit activations of mixed lineage kinase 3 , JNK1 / 2 , and c Jun but also enhanced activation of Akt 1 . ^^^ |
|
| Interacting proteins: Q16584 and P31749 |
Pubmed |
SVM Score :0.0 |
| Neuroprotective effects of preconditioning ischaemia on ischaemic brain injury through inhibition of mixed lineage kinase 3 via NMDA receptor mediated Akt 1 activation . ^^^ |
|
| Interacting proteins: Q16584 and P31749 |
Pubmed |
SVM Score :0.0 |
| The overall goal of this study was to determine the molecular basis by which mixed lineage kinase 3 ( MLK 3 ) kinase and its signaling pathways are negatively regulated by the pro survival Akt pathway in cerebral ischemia . ^^^ |
|
| Interacting proteins: Q16584 and P31749 |
Pubmed |
SVM Score :0.0 |
| Three additional candidate proteins , DPR 2 , MSE 55 , and MLK 3 showed binding to the GTP form of Cdc 42 and weaker binding with Rac , and again no interaction with Rho . ^^^ |
|
| Interacting proteins: Q16584 and P31749 |
Pubmed |
SVM Score :0.0 |
| A dominant negative version of MLK 3 inhibited NF kappaB and CD28RE / AP dependent transcription elicited by the Rho family GTPases Rac and Cdc 42 , thereby providing a novel link between these GTPases and the IKC . . ^^^ |
|
| Interacting proteins: Q16584 and P31749 |
Pubmed |
SVM Score :0.0 |
| The Vav 1 mediated activation of JNK employed a pathway involving Rac , HPK 1 , MLK 3 , and MKK 7 . ^^^ |
|
| Interacting proteins: Q16584 and P31749 |
Pubmed |
SVM Score :0.0 |
| Role of MLK 3 mediated activation of p 70 S6 kinase in Rac 1 transformation . ^^^ We found that the MLK 3 serine / threonine kinase activated JNK and p 70 ( S6K ) , whereas activation of p 70 ( S6K ) by Rac ( 61L ) was significantly inhibited by dominant negative MLK 3 . ^^^ Additionally , the ability of the Rac ( 61L ) effector mutants to activate MLK 3 correlated well with their ability to activate p 70 ( S6K ) and JNK . ^^^ Taken together , these results provide evidence that Rac 1 coordinately activates p 70 ( S6K ) and JNK via MLK 3 activation . ^^^ Finally , we found that co expression of wild type , but not kinase dead , MLK 3 significantly inhibited Rac 1 transforming activity . ^^^ |
|
| Interacting proteins: Q16584 and P31749 |
Pubmed |
SVM Score :0.0 |
| IB2 / JIP2 is a scaffold for the p 38 mitogen activated protein ( MAP ) kinase cascade because it binds to the Rac target MLK 3 , the MAP kinase kinase MKK 3 , and the p 38 MAP kinase . ^^^ |
|
| Interacting proteins: Q16584 and P31749 |
Pubmed |
SVM Score :0.0 |
| Second , some effectors of Rac / Cdc42 ( IQGAP 2 , MLK 3 , PLD 1 ) , but not others ( e . g . ^^^ |
|
| Interacting proteins: Q16584 and P31749 |
Pubmed |
SVM Score :0.0 |
| The reduction of PKB activity releases PKB induced inhibition of MLK 3 and thus further stimulates JNK activity and accelerates the apoptotic effect of GnRH a . ^^^ |
|
| Interacting proteins: Q16584 and P31749 |
Pubmed |
SVM Score :0.0 |
| In the basal state , JIP 1 bind to Akt 1 , MLK 3 at maximum while JIP 1 binds to JNK 3 at minimum . ^^^ While MLK 3 binding to JIP 1 decreased , similar to Akt 1 JIP 1 interaction during ischemia . ^^^ Administration of antioxidant N acetylcysteine ( NAC ) can obviously affected the level of MLK 3 , JNK 3 and Akt 1 binding to JIP 1 and JNK 3 activation in the hippocampus at 15min ischemia . ^^^ |
|
| Interacting proteins: Q16584 and P31749 |
Pubmed |
SVM Score :0.0 |
| Surprisingly , we also found that Rac 3 binds poorly to the known Rac 1 effectors mixed lineage kinases 2 and 3 ( MLK 2 and MLK 3 ) . ^^^ |
|
| Interacting proteins: Q16584 and P31749 |
Pubmed |
SVM Score :0.0 |
| The small Rho family GTPases , Rac and Cdc 42 , have been shown to bind and modulate the activities of signaling proteins , including SPRK , which contain Cdc42 / Rac interactive binding motifs . ^^^ Using a site directed mutagenesis approach , we show that SPRK contains a functional Cdc42 / Rac interactive binding motif that is required for SPRKs association with and activation by Cdc 42 . ^^^ |
|
| Interacting proteins: Q16584 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16584 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16584 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|