| Interacting proteins: Q16543 and P31749 |
Pubmed |
SVM Score :0.0 |
| Akt forms an intracellular complex with heat shock protein 90 ( Hsp 90 ) and Cdc 37 and is destabilized by inhibitors of Hsp 90 function . ^^^ Intracellular Akt is associated with Hsp 90 and Cdc 37 in a complex in which Akt kinase is active and regulated by phosphatidylinositol 3 kinase . ^^^ |
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| Interacting proteins: Q16543 and P31749 |
Pubmed |
SVM Score :0.0 |
| Akt forms a complex with heat shock protein ( Hsp ) 90 and Cdc 37 , and inhibitors of Hsp 90 cause Akt degradation . 17 allylamino 17 demethoxygeldanamycin ( 17 AGG ) is an Hsp 90 inhibitor currently in Phase 1 clinical trial . 17 AAG inhibits Akt activation and expression in tumors , and has antitumor activity in breast cancer xenografts . ^^^ |
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| Interacting proteins: Q16543 and P31749 |
Pubmed |
SVM Score :0.0 |
| Crucially , the CK 2 phosphorylation of Cdc 37 on Ser 13 was essential for the optimal binding activity of Cdc 37 toward various kinases examined , including Raf 1 , Akt , Aurora B , Cdk 4 , Src , MOK , MAK , and MRK . ^^^ |
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| Interacting proteins: Q16543 and P31749 |
Pubmed |
SVM Score :0.0 |
| Hsp 90 maintained an interaction with mature Akt , while Cdc 37 , Hsp 90 ' s kinase specific co chaperone , was lost from the chaperone complex upon Akt maturation . ^^^ Geldanamycin partially disrupted the interaction of Cdc 37 with Akt , but had a much less significant effect on the interaction of Hsp 90 with Akt . ^^^ |
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| Interacting proteins: Q16543 and P31749 |
Pubmed |
SVM Score :0.0 |
| This mutant can bind not only other Hsp 90 client protein kinases , Akt 1 , Aurora B and Cdk 4 , but also Cdc 2 and Cdk 2 , which to date have not been shown to physically interact with Cdc 37 . ^^^ |
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| Interacting proteins: Q16543 and P31749 |
Pubmed |
SVM Score :0.0 |
| We present evidence indicating that phosphorylation of Cdc 37 by CK 2 in conserved Ser 13 in the N terminal extremity was prerequisite for the efficient binding activity of Cdc 37 to protein kinases including Akt , Cdk 4 , MOK , and Raf 1 . ^^^ |
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| Interacting proteins: Q16543 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16543 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16543 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|