| Interacting proteins: Q16513 and P31749 |
Pubmed |
SVM Score :0.82174877 |
| We found that the C terminal region of protein kinase C related kinase 2 ( PRK 2 ) , containing amino acids 862 to 908 , specifically binds to Akt in yeast and mammalian cells . 0.82174877^^^ The protein protein interaction between Akt and the PRK 2 C terminal region specifically down modulates the protein kinase activities of Akt by inhibiting phosphorylation at threonine 308 and serine 473 of Akt . 0.59282781^^^ |
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| Interacting proteins: Q16513 and P31749 |
Pubmed |
SVM Score :0.0 |
| PAK 2 is activated by autophosphorylation upon binding of small G proteins such as Cdc 42 and Rac in the GTP bound state . ^^^ |
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| Interacting proteins: Q16513 and P31749 |
Pubmed |
SVM Score :0.0 |
| Herein , we report that in macrophages , the chemokine RANTES ( regulated on activation normal T cell expressed and secreted ) / CCL5 activates the small GTPase Rac and its downstream target PAK 2 within seconds . ^^^ In agreement , silencing of Rac 1 by shRNA blocks PAK 2 activity and inhibits RANTES / CCL5 induced macrophage polarization and directional migration . ^^^ On the other hand , the tyrosine kinase receptor agonist CSF 1 activates PAK 2 independently of PI3Kgamma and Rac . ^^^ Our results thus demonstrate a chemokine specific signaling pathway in which Gi and PI3Kgamma coordinate to drive Rac 1 and PAK 2 activation that eventually controls the chemotactic response . . ^^^ |
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| Interacting proteins: Q16513 and P31749 |
Pubmed |
SVM Score :0.0 |
| Activation of full length PAK 2 by Rac or Cdc 42 stimulates cell survival and protects cells from cell death , whereas caspase activated PAK 2p34 induces a cell death response . ^^^ |
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| Interacting proteins: Q16513 and P31749 |
Pubmed |
SVM Score :0.0 |
| Surprisingly , however , CRP did not activate the low molecular weight G protein Rac and stimulated only a small increase in activity of p 21 associated kinase 2 ( PAK 2 ) , despite the fact that both proteins are regulated downstream of Vav 1 in other cells . ^^^ Further , activation of Rac and PAK 2 by thrombin was maintained in platelets from mice deficient in Vav 1 . ^^^ |
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| Interacting proteins: Q16513 and P31749 |
Pubmed |
SVM Score :0.0 |
| Caspase activated PAK 2 is regulated by subcellular targeting and proteasomal degradation . p 21 activated protein kinases ( PAKs ) are a family of serine / threonine protein kinases that are activated by binding of the p 21 G proteins Cdc 42 or Rac . ^^^ |
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| Interacting proteins: Q16513 and P31749 |
Pubmed |
SVM Score :0.0 |
| This event was marked by the induction of several protein kinases such as phosphatidylinositol 3 kinase ( PI3K ) , phosphorylated protein kinase B ( PKB ; also known as Akt ) , p 21 activated kinase 2 ( PAK 2 ) , and their downstream effector ( ERK ) as well as an increase in PKB intrinsic activity . ^^^ Interestingly , the event of germ cell loss induced by AF 2364 in vivo was also associated with induction of PI3K , p PKB , PAK 2 , and p ERK as well as a surge in intrinsic PKB activity . ^^^ |
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| Interacting proteins: Q16513 and P31749 |
Pubmed |
SVM Score :0.0 |
| Rac 1 exerts its effects in the epidermis by negatively regulating c Myc through p 21 activated kinase 2 ( PAK 2 ) phosphorylation . ^^^ |
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| Interacting proteins: Q16513 and P31749 |
Pubmed |
SVM Score :0.0 |
| Merlin , a cellular substrate of PAK 2 , is homologous to the ezrin radixin moesin family and plays a critical role in Rac signaling . ^^^ |
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| Interacting proteins: Q16513 and P31749 |
Pubmed |
SVM Score :0.0 |
| The PRK 2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytoskeletal organization . ^^^ |
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| Interacting proteins: Q16513 and P31749 |
Pubmed |
SVM Score :0.0 |
| Rac to Rho point mutations ( V85D or A88D ) within loop 6 of Rac promoted its association with PRK 2 and ROCK , whereas the reciprocal Rho ( D87V / D90A ) double mutant significantly reduced effector binding capacity . ^^^ |
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| Interacting proteins: Q16513 and P31749 |
Pubmed |
SVM Score :0.0 |
| On the other hand , co expression of full length protein kinase C related kinase 1 ( PRK1 / PKN ) or 2 ( PRK 2 ) inhibited PDK 1 ( A280V ) mediated PKB phosphorylation . ^^^ Finally , unlike the carboxyl terminal fragment of PRK 2 , which has been shown to bind PDK 1 and allow the enzyme to phosphorylate PKB at both Thr ( 308 ) and Ser ( 473 ) , full length PRK 2 and its related kinase PRK1 / PKN may both play negative roles in PKB mediated downstream biological events . . ^^^ |
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| Interacting proteins: Q16513 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16513 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16513 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16513 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16513 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16513 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16513 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16513 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16513 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16513 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16513 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16513 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16513 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16513 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16513 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16513 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16513 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|