| Akt mediated phosphorylation of EZH 2 suppresses methylation of lysine 27 in histone H 3 . ^^^ Here , we show that Akt phosphorylates EZH 2 at serine 21 and suppresses its methyltransferase activity by impeding EZH 2 binding to histone H 3 , which results in a decrease of lysine 27 trimethylation and derepression of silenced genes . ^^^ Our results imply that Akt regulates the methylation activity , through phosphorylation of EZH 2 , which may contribute to oncogenesis . . ^^^ |