| Interacting proteins: Q13322 and P31749 |
Pubmed |
SVM Score :0.96180139 |
| We propose a model in which Grb 10 acts as a coactivator for Akt by virtue of its ability to form a complex with Akt and its SH 2 domain dependent translocation to the cell membrane . . 0.96180139^^^ |
|
| Interacting proteins: Q13322 and P31749 |
Pubmed |
SVM Score :0.58567197 |
| We provide evidence that Akt directly binds Grb 10 and is able to phosphorylate Grb 10 in an in vitro kinase assay . 0.58567197^^^ |
|
| Interacting proteins: Q13322 and P31749 |
Pubmed |
SVM Score :0.0 |
| Grb 10 inhibits insulin stimulated insulin receptor substrate ( IRS ) phosphatidylinositol 3 kinase / Akt signaling pathway by disrupting the association of IRS 1 / IRS 2 with the insulin receptor . ^^^ |
|
| Interacting proteins: Q13322 and P31749 |
Pubmed |
SVM Score :0.0 |
| The negative role of Grb 10 in insulin signaling was established by suppression of endogenous Grb 10 by RNA interference in HeLa cells overexpressing the insulin receptor , which enhanced insulin stimulated phosphorylation of MAPK , Shc , and Akt . ^^^ |
|
| Interacting proteins: Q13322 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13322 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13322 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13322 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|