| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| Sequence analysis of peptide fragments from Gox identified it as Rac 2 , a member of the Ras superfamily of GTP binding proteins . ^^^ |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| By substituting the corresponding 2 . 45 kilobase EcoRI toHindIII fragments of Rac prophage isolated from sbcA+ , sbcA 6 , and sbcA 23 strains for the shortened segment of one of the deletion mutant plasmids , we were able to show that sbcA mutations map in this region . ^^^ |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| Among the homologous sequences found , one fragment from E . coli B , similar to a piece of Rac prophage , and two fragments from Shigella flexneri were cloned and sequenced . dicF like elements similar to transcriptional terminators were found in each sequence , but unlike dicF these had no effect on division in E . coli K 12 . ^^^ |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| Eight stable PAK fragments of varying lengths , each containing the CRIB motif ( residues 75 88 ) , were expressed in Escherichia coli , and their ability to interact with Cdc 42 and Rac was assessed using scintillation proximity assays , isothermal titration calorimetry , and fluorescence techniques . ^^^ The shortest fragments examined ( residues 70 94 and 75 94 ) bound only weakly to either Cdc 42 or Rac . ^^^ PAK fragments bound with approximately 3 10 fold higher affinity to Cdc 42 than to Rac and bound Q61L variants with 5 10 fold higher affinity than wild type . ^^^ It is suggested that these PAK fragments ( in the absence of Cdc 42 or Rac ) might exist predominantly in an inactive conformation that slowly interconverts with an active conformation and / or a slow conformational change may occur upon binding to Cdc42 / Rac . ^^^ |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| The responses to CRF were competitively antagonised by the following peptide fragments ( mean pKB value ) : alpha helical CRF ( 9 41 ) ( 7 . 54 ) , [ D Phe 12 , Nle 21 , 38 , C alpha MeLeu 37 ] CRF ( 12 41 ) ( 8 . 36 ) and [ D Tyr 12 ] astressin ( 9 . 49 ) and by the selective , non peptidic CRF 1 receptor antagonists , CP 154 , 526 ( 7 . 76 ) and antalarmin ( 9 . 19 ) . ^^^ |
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| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| Introducing dominant negative Rac 3 and Pak 1 fragments into a breast cancer cell line revealed that active Rac 3 drives Pak and JNK kinase activities by two separate pathways . ^^^ |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| The Akt protein incubation with active caspases in vitro revealed that it was cleaved at three sites to produce 40 and 44 kDa fragments . ^^^ |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| Binding studies using isolated fragments of Vav and Sos indicate phosphatidylinositol 3 kinase substrate promotes the binding of the pleckstrin homology domain to the Dbl homology domain and blocks Rac binding to the DH domain , whereas phosphatidylinositol 3 kinase products disrupt the Dbl homology / pleckstrin homology interactions and permit Rac binding . ^^^ |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| Cotransfection of these DNA fragments with a TbetaRII / I cDNA hybrid receptor , capable of inducing a TGF beta 1 dominant negative effect , showed that TGF beta 1 inhibits specifically COL2A1 gene transcription in RAC by a 63 bp proximal promoter . ^^^ |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| PCR amplified hypervariable 16S rDNA fragments of the bacterium Escherichia coli DF 1020 and cDNA of the 6 phosphofructo 1 kinase isoenzymes ( PFK 1 , EC 2 . 7 . 1 . 11 ) in rat brain were chosen as model systems for essentially heterogeneous templates . ^^^ |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| The role of PI 3 K / akt signaling during migration in response to the uPA fragments is not understood . ^^^ |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| In the study of the molecular mechanism of this phenomenon , it was found that GnTV AS reduced the expressions of anti apoptotic proteins , such as phosphorylated protein kinase B and phosphorylated Bad as well as Bcl 2 and Bcl 10 ( L ) , and elevated those of pro apoptotic proteins , including Bax , full length caspase 3 and its activated fragments as well as anti oncoprotein p 53 . ^^^ |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| The phosphorylated Akt and activated fragments of caspase 9 , caspase 3 were examined by Western blotting analysis . ^^^ |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| We found that both apelin fragments inhibited adenylyl cyclase and increased the phosphorylation of ERK or Akt . ^^^ |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| We show that AHNAK is a phosphorylation substrate of protein kinase B ( PKB ) in vitro and in vivo . ^^^ Nuclear exclusion of AHNAK is mediated through a nuclear export signal ( NES ) in a manner that depends on the phosphorylation of serine 5535 of AHNAK by PKB , a process that also plays a major role in determining extranuclear localization of AHNAK . ^^^ AHNAK is a new PKB substrate whose function , though unknown , is likely to be regulated by its localization , which is in turn regulated by PKB . . ^^^ Protein kinase B phosphorylates AHNAK and regulates its subcellular localization . ^^^ |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| ANCA IgG activated PI 3 kinase generating PIP ( 3 ) , activated protein kinase B ( PKB ) , and p 21 ( ras ) ; activation of each mediator was inhibited with pertussis toxin , but PI3K and PKB were not activated by ANCA IgG F ( ab ' ) ( 2 ) fragments . ^^^ |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| Luciferase reporter constructs , carrying different length fragments of the human sod 1 gene promoter , have identified a region between 552 and 355 that is targeted by PI3K and Akt and that contains a putative site of regulation by nuclear factor kappaB ( NF kappaB ) . ^^^ |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q09666 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|