| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| In L 6 myocytes , insulin increased phosphorylation of Akt 1 and glycogen synthase kinase 3 alpha and beta ( GSK 3 alpha and beta ) , resulting in its activation and inactivation , respectively . ^^^ |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| Consistent with unimpaired insulin activation of PKB , the stimulation of Ser 21 and Ser 9 phosphorylation of glycogen synthase kinase 3 alpha and beta , and the apparent phosphorylation level of 4E BP 1 ( eukaryotic initiation factor 4 binding protein 1 ) , were similar in transduced and control hepatocytes . ^^^ |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| In the presence of low concentrations of serum , enforced PTEN expression results in a marked increase in cellular apoptosis , a finding which is consistent with the capacity of PTEN to alter the phosphorylation , and presumably function , of the AKT , BAD , p70S6 kinase and GSK 3 alpha apoptosis regulators . ^^^ |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| In L6hIR , inhibition of PKC zeta activity by either a PKC zeta antisense or a dominant negative mutant also reduced by 75 % insulin inactivation of GSK 3 alpha and beta ( p < 0 . 001 ) and insulin stimulation of GS ( p < 0 . 002 ) , similar to Akt / PKB inhibition . ^^^ Inhibition of PKC zeta activity , however , reduced Akt / PKB phosphorylation of the key serine sites on GSK 3 alpha and beta by > 80 % ( p < 0 . 001 ) and prevented full GSK 3 inactivation by insulin . ^^^ In these cells , insulin inhibition of GSK 3 alpha and beta requires dual phosphorylation by both Akt / PKB and PKC zeta . . ^^^ |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| Dose dependent down regulation of the proliferative activity , activation of the apoptotic machinery , and cell killing by PKC 412 ( 0 1 microM ) in Rat1a fibroblasts and H ras oncogene transformed fibroblasts correlated with a decrease of Akt phosphorylation and a reduced phosphorylation of the endogenous Akt substrate GSK 3 alpha . ^^^ |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| BDM also blocked the action of HGA on insulin stimulated PKB and GSK 3 alpha . ^^^ |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| These results indicate that PUGNAc is an effective inhibitor of O GlcNAcase in skeletal muscle and suggest that O GlcNAc modification of proteins can induce insulin resistance in skeletal muscle independent of attenuated phosphorylation of Akt , GSK 3 alpha , GSK 3 beta , and a 160 kDa protein with an Akt phosphomotif . . ^^^ |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| High levels of basal Akt , GSK 3 alpha / beta and p70S6 kinase phosphorylation are all inhibited by the PI 3 kinase inhibitor , LY 294002 . ^^^ |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| Western blotting using an antibody specific for the PKB / SGK1 consensus phosphorylation site in GSK3a / beta ( serine 21 and 9 respectively ) revealed an increase in GSK3a / beta phosphorylation in human embryonic kidney 293 ( HEK 293 ) cells overexpressing wild type SGK 1 , constitutively active SGK 1 , but not catalytically inactive SGK 1 . ^^^ |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49840 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|