| Interacting proteins: P49137 and P31749 |
Pubmed |
SVM Score :0.0 |
| Finally , downstream of Rac and p 38 mitogen activated protein kinase ( MAPK ) , Gas6 / Ark signaling promoted activation of MAPK activated protein kinase 2 and induced phosphorylation of HSP 25 , a known regulator of cortical actin remodeling . ^^^ |
|
| Interacting proteins: P49137 and P31749 |
Pubmed |
SVM Score :0.0 |
| We showed previously that Akt exists in a signaling complex with p 38 MAPK , MAPK activated protein kinase 2 ( MAPKAPK 2 ) , and heat shock protein 27 ( Hsp 27 ) ; and Hsp 27 dissociates from the complex upon neutrophil activation . ^^^ |
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| Interacting proteins: P49137 and P31749 |
Pubmed |
SVM Score :0.0 |
| Western blotting and immunoprecipitation for targets of p 38 ( MAPK ) ( MAPKAP kinase 2 ) and PI 3 K ( Akt ) were also performed . ^^^ |
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| Interacting proteins: P49137 and P31749 |
Pubmed |
SVM Score :0.0 |
| It may be concluded that aberrant mitogenic signaling in human breast cancer in vivo involves Pak , p 38 MAPK and MAPKAPK 2 downstream of PI 3 K , but neither of PKB or p 70 S6K . ^^^ |
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| Interacting proteins: P49137 and P31749 |
Pubmed |
SVM Score :0.0 |
| In microcystin transformed cells , PI3K , MAPKAPK 2 , Akt , cyclin D 1 and cyclin D 3 in the Akt pathway ; IQGAP 2 , RabGTPase , Rap1GAP , RasGAP , R Ras , Krev 1 and TC 21 of the Ras GTP / GDP protein family ; and A Raf , B Raf and PAK in the Ras / MAPK pathway were all markedly upregulated . ^^^ |
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| Interacting proteins: P49137 and P31749 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation and glutathione S transferase ( GST ) pull down studies showed that Akt was associated with p 38 kinase , MK 2 , and Hsp 27 in neutrophils , and Hsp 27 dissociated from the complex upon activation . ^^^ Active recombinant MK 2 phosphorylated recombinant Akt and Akt in anti Akt , anti MK 2 , anti p 38 , and anti Hsp 27 immunoprecipitates , and this was inhibited by an MK 2 inhibitory peptide . ^^^ We conclude that Akt exists in a signaling complex containing p 38 kinase , MK 2 , and Hsp 27 and that p 38 dependent MK 2 activation functions as PDK 2 in human neutrophils . . ^^^ |
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| Interacting proteins: P49137 and P31749 |
Pubmed |
SVM Score :0.0 |
| Here , we describe a single microtiter based format that simultaneously quantifies protein kinase activities in the phosphatidylinositol 3 kinase pathway ( Akt ) , nuclear factor kappaB pathway ( IKK ) , and three core mitogen activated protein kinase pathways ( ERK , JNK 1 , MK 2 ) . ^^^ |
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| Interacting proteins: P49137 and P31749 |
Pubmed |
SVM Score :0.0 |
| These compounds were competitive inhibitors of ATP binding by MEK 1 kinase , and they had minimal or no effect on Raf , epidermal growth factor receptor ( EGFR ) , Akt , cyclin dependent kinase 4 ( CDK 4 ) , or MK 2 kinases at concentrations > 100 fold higher than those that inhibited MEK 1 kinase . ^^^ |
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| Interacting proteins: P49137 and P31749 |
Pubmed |
SVM Score :0.0 |
| The general protocol was developed for the kinase Akt and then easily extended to measure protein kinase A ( PKA ) and mitogen activated protein kinase associated protein kinase 2 ( MK 2 ) activities . ^^^ |
|
| Interacting proteins: P49137 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49137 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49137 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49137 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49137 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49137 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49137 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49137 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|