| Interacting proteins: P45985 and P31749 |
Pubmed |
SVM Score :1.2521612 |
| Co immunoprecipitation analysis revealed that endogenous Akt physically interacted with endogenous SEK 1 in cells and that this interaction was promoted by insulin . 1.2521612^^^ |
|
| Interacting proteins: P45985 and P31749 |
Pubmed |
SVM Score :0.58643846 |
| Dissociated Akt 1 binds to SEK 1 and ASK 1 and inhibits their enzyme activity by phosphorylating SEK 1 on the Ser 80 residue and ASK 1 on the Ser 83 residue . 0.58643846^^^ |
|
| Interacting proteins: P45985 and P31749 |
Pubmed |
SVM Score :1.1229804 |
| Concomitantly , Akt 1 interacts with stress activated protein kinase / extracellular signal regulated kinase ( SEK ) 1 ( also known as MKK 4 ) and inhibits SEK 1 activity . 1.1229804^^^ |
|
| Interacting proteins: P45985 and P31749 |
Pubmed |
SVM Score :0.0 |
| To further examine the role of JNK / SAPK signaling cascades in apoptosis resulting from microtubular dysfunction induced by paclitaxel , we have coexpressed dominant negative ( dn ) mutants of signaling proteins of the JNK / SAPK pathway ( Ras , ASK 1 , Rac , JNKK , and JNK ) in human ovarian cancer cells with a selectable marker to analyze the apoptotic characteristics of cells expressing dn vectors following exposure to paclitaxel . ^^^ |
|
| Interacting proteins: P45985 and P31749 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of both JNKs and a proximal activator , MAP kinase kinase 4 ( MKK 4 ) , in response to UV irradiation was inhibited in Myr Akt expressing PC 12 cells . ^^^ |
|
| Interacting proteins: P45985 and P31749 |
Pubmed |
SVM Score :0.0 |
| We assessed whether exercise activates MAP kinase proteins ( ERK1 / 2 , SEK 1 , and p 38 MAP kinase ) as well as Akt and PYK 2 in skeletal muscle from healthy volunteers obtained during and after one leg cycle ergometry at approximately 70 % VO2max . ^^^ |
|
| Interacting proteins: P45985 and P31749 |
Pubmed |
SVM Score :0.0 |
| In particular , activation of the JNK kinase stress and extracellular activated kinase 1 ( SEK 1 ) and of JNK in macrophages occurs independently of actin rearrangements and of the GTPases Cdc 42 and Rac , essential mediators in other cells . ^^^ |
|
| Interacting proteins: P45985 and P31749 |
Pubmed |
SVM Score :0.0 |
| H2O2 induced phosphorylation of SAPK / Erk kinase ( SEK 1 ) at Thr 261 , which is an upstream regulator of JNK , was also attenuated by Ang 1 dependent activation of the PI 3 kinase / Akt pathway . ^^^ |
|
| Interacting proteins: P45985 and P31749 |
Pubmed |
SVM Score :0.0 |
| MKK 4 activation by Gbeta gamma was blocked by dominant negative Rho and Cdc 42 , whereas MKK 7 activation was blocked by dominant negative Rac . ^^^ These results indicate that Gbeta gamma induces JNK activation mainly through MKK 4 activation dependent on Rho , Cdc 42 , and tyrosine kinase , and to a lesser extent through MKK 7 activation dependent on Rac . . ^^^ |
|
| Interacting proteins: P45985 and P31749 |
Pubmed |
SVM Score :0.0 |
| Jurkat / IGF 1R cells exhibited enhanced constitutive Akt phosphorylation compared with mock transfected controls , but IGF 1 induced transient phosphorylation of MKK 4 , JNKs , and c Jun . ^^^ |
|
| Interacting proteins: P45985 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45985 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45985 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45985 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45985 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45985 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45985 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45985 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45985 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45985 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45985 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45985 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|