| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| STAT 1 knockout mice showed increased phosphorylated Akt and decreased procaspase 3 cleavage . ^^^ |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| We further show that GPCR agonists stimulate tyrosine phosphorylation of STAT 1 and STAT 3 proteins in a Rac dependent manner . ^^^ |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| However , it did not inhibit the activation of Akt or MAP kinase , nor did it inhibit the serine phosphorylation of STAT 1 . ^^^ |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| To determine whether leptin signal transduction is exerted directly upon insulin sensitive tissues in vivo , we examined the ability of 4 leptin to acutely stimulate phosphorylation of STAT 3 , STAT 1 , and MAPK , and activities of PI 3 kinase and Akt , in insulin sensitive tissues of normal rats . ^^^ |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| We show that phosphatidylinositol 3 kinase ( PI3K ) and its effector kinase Akt play an important role in the serine phosphorylation of STAT 1 and in the activation of gene expression in response to interferon gamma ( IFN gamma ) . ^^^ Constitutively active forms of PI3K or Akt activate and their dominant negative derivatives inhibit STAT 1 driven transactivation in response to IFN gamma . ^^^ In addition to PI3K and Akt , JAK 1 , JAK 2 , and the tyrosine 440 STAT 1 docking residue of IFNGR 1 are required for STAT 1 to be phosphorylated on serine . ^^^ Taken together , these results suggest that the following events lead to the activation of STAT 1 upon IFN gamma stimulation : 1 ) PI3K and Akt are activated by the occupied receptor and Tyr 440 is phosphorylated by the activated JAKs ; 2 ) STAT 1 docks to Tyr 440 ; and 3 ) Tyr 701 is phosphorylated by the JAKs and Ser 727 is phosphorylated by a kinase downstream of Akt . . ^^^ |
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| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| Signaling molecules Stat 3 , Stat 1 , MAPK , or protein kinase B , which can be activated by PRL in other target cells , were not activated by PRL in prostate tissue . ^^^ |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| Notably , the enhanced serine phosphorylation of STAT 1 was observed upon Ras transfection , which was specifically associated with the induction of MAPK , but not Akt activity in these cells . ^^^ |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| We also observed that while TPO efficiently activated various signaling pathways in CD34+ cells , megakaryocytes , and platelets ( MAPK p42 / 44 , PI 3K AKT , STAT proteins ) , IL 6 stimulated phosphorylation of STAT 1 , 3 , and 5 proteins only in CD34+ cells and megakaryoblasts . ^^^ |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| To assess insulin receptor ( IR ) , Shc , STAT 1 , ERK , and Akt phosphorylation in response to insulin in lacrimal gland and salivary gland , tissues from female and male rats ( n = 5 8 / group ) were submitted to immunoprecipitation and immunoblotting or Western blotting protocol , and phosphorylation level was determined by densitometry . ^^^ |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| We show that increasing the expression of the receptor results in dramatic shifts in signaling with attenuation of EGF induced Ras , extracellular signal related kinases ( ERKs ) , and Akt activation , as well as amplification of STAT 1 and STAT 3 signaling . ^^^ |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| Abrogation of the IFN stimulated Akt activation by phosphatidylinositol 3 kinase ( PI 3K ) inhibitors prevents IFN induced adhesion in these cells , and IFN activation of the Stat 1 dependent guanylate binding protein ( GBP ) gene is not affected . ^^^ |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| The IL 6 family cytokine oncostatin M was also capable of activating MAPK , STAT 3 , STAT 1 , Akt , and p 38 in both WT and SYF cells . ^^^ |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of signal transducer and activator of transcription 1 ( STAT 1 ) , STAT 3 , extracellular signal regulated kinase ( ERK ) , or Akt was assessed by immunoblot analysis . ^^^ |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| CT 1 induced rapid phosphorylation of Jak , Jak 2 , STAT 1 , STAT 3 , p42 / 44 MAPK and Akt in cultured adult cardiac fibroblasts . ^^^ |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| Additionally , most GISTs showed activation of MAPK p42 / 44 , AKT , S6K , STAT 1 , and STAT 3 . ^^^ Using GIST in vitro models , we showed that activation of MAPK p42 / 44 , AKT , and S6K was KIT dependent , whereas STAT 1 and STAT 3 phosphorylation was only partially dependent on KIT activation . ^^^ |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| STAT 1 deficient erythroblasts from phenylhydrazine primed mice displayed enhanced phosphorylation of STAT5a / b , Erk1 / 2 , and protein kinase B ( PKB ) / Akt . ^^^ |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that in response to IL 31 , its receptor complex recruits Jak 1 , Jak 2 , STAT 1 , 3 , 5 signaling pathways , as well as the Pi 3 kinase / AKT cascade . ^^^ |
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| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| Several KIT activating mutations , which are largely responsible for the development of this tumor , promote cell survival , proliferation , and migration through different pathways such as MAPK p42 / 44 , AKT , S6K , STAT 1 , and STAT 3 . ^^^ |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| IFN gamma rapidly phosphorylated signal transducers and activators of transcription 1 ( STAT 1 ) and STAT 6 but did not enhance phosphorylation of STAT 3 , Akt and extracellular signal regulated kinase ( ERK ) and nuclear translocation of NF kappaB p 65 . ^^^ |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| Stimulation of neutrophils with IFN alpha or IFN gamma resulted in tyrosine phosphorylation of STAT 1 and STAT 3 but not phosphorylation of STAT 5 , Akt , extracellular signal regulated kinase , and p 38 mitogen activated protein kinase . ^^^ |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| Addition of 4 nM recombinant PANDER protein to betaTC 3 cells or infection of Ad PANDER did not affect Akt and STAT 1 phosphorylation , Bcl 2 , Fas , and NF kappaB protein levels . ^^^ |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| IFN gamma rapidly phosphorylated signal transducers and activators of transcription 1 ( STAT 1 ) , STAT 3 , and STAT 6 as well as ERK , whereas enhanced neither phosphorylation of Akt nor nuclear translocation of nuclear factor kappaB ( NF kappaB ) p 65 . ^^^ |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| Finally , ERK dephosphorylation and STAT 1 up regulation induced by ToxB were mimicked by a dominant negative ( N 17 ) mutant of Rac 1 . ^^^ |
|
| Interacting proteins: P42224 and P31749 |
Pubmed |
SVM Score :0.0 |
| IFN gamma also stimulated Akt activity , and both Fas trafficking and Stat 1 activation were inhibited by blocking PI3K , Akt , or Jak 2 . ^^^ |
|