| Interacting proteins: P41279 and P31749 |
Pubmed |
SVM Score :0.0 |
| Akt dependent phosphorylation specifically regulates Cot induction of NF kappa B dependent transcription . ^^^ The Akt ( or protein kinase B ) and Cot ( or Tpl 2 ) serine / threonine kinases are associated with cellular transformation . ^^^ Here we show that Akt and Cot physically associate and functionally cooperate . ^^^ Akt appears to function upstream of Cot , as Akt can enhance Cot induction of NF kappa B dependent transcription , and dominant negative Cot blocks the activation of this element by Akt . ^^^ Furthermore , deletion analysis shows that binding to Akt is critical for Cot function . ^^^ |
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| Interacting proteins: P41279 and P31749 |
Pubmed |
SVM Score :0.0 |
| Cytoplasmic serine threonine kinases ( Raf , Akt , Tpl 2 ) are also mutated or activated in several types of human malignancies . ^^^ |
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| Interacting proteins: P41279 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41279 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41279 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|