| Interacting proteins: P25098 and P31749 |
Pubmed |
SVM Score :0.84950845 |
| We found that Akt physically interacts with G protein coupled receptor kinase 2 ( GRK 2 ) , and that this interaction inhibits Akt activity . 0.84950845^^^ |
|
| Interacting proteins: P25098 and P31749 |
Pubmed |
SVM Score :0.0 |
| Both pertussis toxin ( 10 ng / ml ) , which inactivates Gi / Go proteins , and expression of a peptide derived from the carboxyl terminus of the beta adrenergic receptor kinase 1 , which specifically blocks signaling mediated by the betagamma subunits of G proteins , completely blocked the PrRP induced Akt activation , suggesting that Gi / Go proteins are involved in PrRP induced Akt activation , as they are in the activation of ERK by PrRP . ^^^ |
|
| Interacting proteins: P25098 and P31749 |
Pubmed |
SVM Score :0.0 |
| Expression of the G beta gamma sequestrant peptide G protein coupled receptor kinase 2 carboxy terminus inhibited the lysophosphatidic acid and serum mediated activation of Erk 1 / 2 and Akt but showed no effect on the IGF 1 or EGF mediated response . ^^^ |
|
| Interacting proteins: P25098 and P31749 |
Pubmed |
SVM Score :0.0 |
| Moreover , the calcium response and phosphorylation of protein kinase B and extracellular regulated kinase in response to CCL 4 were significantly increased in GRK2+ / T cells , showing that signaling is increased when the level of GRK 2 is reduced . ^^^ |
|
| Interacting proteins: P25098 and P31749 |
Pubmed |
SVM Score :0.0 |
| Physiologic expression of GRK 2 diminished ( a ) phosphoinositide hydrolysis elicited through the PDGFRbeta but not heterotrimeric G proteins ; ( b ) Akt activation evoked by the PDGFRbeta but not the EGFR ; and ( c ) PDGF induced tyrosyl phosphorylation of the PDGFRbeta itself . ^^^ |
|
| Interacting proteins: P25098 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25098 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25098 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|