| Interacting proteins: P23769 and P31749 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of GATA 2 by Akt increases adipose tissue differentiation and reduces adipose tissue related inflammation : a novel pathway linking obesity to atherosclerosis . ^^^ METHODS AND RESULTS : We show that insulin induces GATA 2 phosphorylation on serine 401 in a PI 3K / Akt dependent manner . ^^^ A GATA 2 mutant not phosphorylable by Akt ( GATA 2 ( S401A ) ) acts similarly to wild type GATA 2 . ^^^ In contrast , a GATA 2 mutant that mimics Akt phosphorylation ( GATA 2 ( S401D ) ) is restrained in the cytoplasm . ^^^ |
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| Interacting proteins: P23769 and P31749 |
Pubmed |
SVM Score :0.0 |
| We found that ES MV ( 10 microg / ml ) isolated from murine ES cells ( ES D 3 ) in serum free cultures significantly ( 1 ) enhanced survival and improved expansion of murine HPC , ( 2 ) upregulated the expression of early pluripotent ( Oct 4 , Nanog and Rex 1 ) and early hematopoietic stem cells ( Scl , HoxB 4 and GATA 2 ) markers in these cells , and ( 3 ) induced phosphorylation of MAPK p42 / 44 and serine threonine kinase AKT . ^^^ |
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