Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Akt / protein kinase B up regulates Bcl 2 expression through cAMP response element binding protein . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
A new phosphospecific cell based ELISA for p42 / p44 mitogen activated protein kinase ( MAPK ) , p 38 MAPK , protein kinase B and cAMP response element binding protein . ^^^ Using phosphospecific antibodies , we have developed ELISA techniques enabling non radioactive semi quantitative assessment of the activation state of p42 / p44 mitogen activated protein kinase ( MAPK ) , p 38 MAPK , protein kinase B and the transcription factor cAMP response element binding protein ( CREB ) in 96 well plates . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Furthermore , 17beta estradiol induced phosphorylation of the cAMP response element binding protein ( CREB ) at Ser ( 133 ) within 15 min and then upregulated Bcl 2 in a PI 3 K / Akt dependent manner . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Regulation of the PRL promoter by Akt through cAMP response element binding protein . ^^^ Cotransfection with a constitutively active Akt induced the rPRL promoter activity and cotransfection with a dominant negative cAMP response element binding protein ( CREB ) completely abolished the response of the rPRL promoter to the constitutively active Akt . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
After treatments , cell lysates were prepared , and the activation state of AKT and cAMP response element binding protein ( CREB ) was determined by Western blot analysis using phosphorylation site specific antibodies . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
We confirmed that Akt enzymatic activity is elevated in both the nuclear and cytosolic fractions of brain tissue subjected to 1 h of ischemia . cAMP response element binding protein ( CREB ) , an intranuclear target molecule of Akt , exhibited increased phosphorylation after 1 h of MCAO . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Dopamine induces a PI 3 kinase independent activation of Akt in striatal neurons : a new route to cAMP response element binding protein phosphorylation . ^^^ Furthermore , overexpression of a mutant form of Akt that can not be activated impaired cAMP response element binding protein ( CREB ) phosphorylation induced by SKF 38393 and quinpirole treatments . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
TRAIL induced distinct short term ( 1 60 min ) and long term ( 3 24 h ) effects on the protein kinase B ( PKB ) / Akt ( Akt ) , extracellular signal regulated kinase ( ERK ) , cAMP response element binding protein ( CREB ) , nuclear factor kappa B ( NF kappaB ) and caspase pathways . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Alleviating the suppression of glycogen synthase kinase 3beta by Akt leads to the phosphorylation of cAMP response element binding protein and its transactivation in intact cell nuclei . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Downstream targets of PI 3 kinase , such as Akt and the transcription factor cAMP response element binding protein ( CREB ) , are activated by insulin and NT 3 and regulate sensory neuron gene expression . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
GLP 1 receptor activation also promotes cell survival in beta cells and neurons via increased levels of cAMP leading to cAMP response element binding protein activation , enhanced insulin receptor substrate 2 activity and , ultimately , activation of Akt . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Resveratrol induced expression of Bcl 2 and caused its phosphorylation along with phosphorylation of cAMP response element binding protein ( CREB ) , Akt , and Bad . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Insulin also induced rapid and long term ( 30 h ) PI 3 K dependent phosphorylation of Akt and cAMP response element binding protein ( CREB ) . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
This study was designed to determine whether cardioprotection afforded by A2A adenosine receptor stimulation can be sustained and to determine the effect of an A2A adenosine receptor agonist on Akt and cAMP response element binding protein ( CREB ) activation , as well as Hsp 27 and Hsp 70 protein expression in such events . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Resveratrol mediated activation of cAMP response element binding protein through adenosine A 3 receptor by Akt dependent and independent pathways . ^^^ A recent study documented a role of adenosine A ( 3 ) Akt cAMP response element binding protein ( CREB ) survival signaling in resveratrol preconditioning of the heart . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Accordingly , we examined the effects of 4 n butylresorcinol on the ERK and Akt signaling pathways . 4 n Butylresorcinol did not induce ERK , Akt activation , or MITF degradation , and had no effect on cAMP response element binding protein ( CREB ) phosphorylation , which stimulates MITF expression . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Immunofluorescent stains were performed using antibodies against phosphorylated Akt ( pAkt ) and cAMP response element binding protein ( CREB ) ( pCREB ) , and ceramide . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
An analog of a dipeptide like structure of FK 506 increases glial cell line derived neurotrophic factor expression through cAMP response element binding protein activated by heat shock protein 90 / Akt signaling pathway . ^^^ Leu Ile elicited an increase in cAMP response element binding protein ( CREB ) phosphorylation , which was inhibited by GA , indicating that CREB is a downstream target of Hsp90 / Akt signaling . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
The present study examined whether activation of HL 60 derived neutrophils by C5a modulates the transcription of two members of the Bcl 2 family , Bax ( pro apoptotic ) and Bcl 2 ( anti apoptotic ) molecules , and whether the cAMP response element binding protein ( CREB ) transcription factor mediates these effects through the phosphatidylinositol 3 kinase ( PI3K ) / Akt and extra cellular signal regulated kinase ( ERK ) signalling pathways . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Insulin like growth factor 1 ( IGF 1 ) induces the activation / phosphorylation of Akt kinase and cAMP response element binding protein ( CREB ) by activating different signaling pathways in PC 12 cells . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
We set out to identify the time courses of the activation of mitogen associated protein kinase ( MAPK ) , transcription factor cAMP response element binding protein ( CREB ) and Akt / PKB ( protein kinase B ) in the insular cortex and hippocampus of rats subsequent to novel taste learning . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Akt can also regulate several transcription factors , including E2F , CREB , and the Forkhead family member Daf 16 [ 2 ] [ 3 ] [ 4 ] . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
In addition , the Akt neuroprotective signaling pathway activates CREB , and CREB synthesis and phosphorylation promote the survival of many cells , including neurons , in vitro . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
HIV 1 Tat protein down regulates CREB transcription factor expression in PC 12 neuronal cells through a phosphatidylinositol 3 kinase / AKT / cyclic nucleoside phosphodiesterase pathway . ^^^ In blocking experiments performed with pharmacological inhibitors , Tat decreased the intracellular levels of cAMP and CREB Ser 133 phosphorylation through a signal transduction pathway involving the sequential activation of phosphatidylinositol 3 kinase , AKT , and cyclic nucleoside phosphodiesterases . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
These results show that there may be , as yet unidentified , intracellular signaling pathways other than the PtdIns 3 K Akt , MAPK and CREB signaling , to regulate survival promotion . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Activation of Akt ( protein kinase B ) with serum increased phospho serine 9 GSK 3 beta ( the inactive form of the enzyme ) , inhibited GSK 3 beta activity , and increased CREB DNA binding activity . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
We found that phosphorylation of the cyclic AMP response element binding protein ( CREB ) is only transiently increased following stimulation of MSNs by BDNF , whereas increased phosphorylation of the extracellular signal regulated kinases 1 and 2 ( Erk1 / 2 ) and Akt is sustained for longer than 4 h . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
The serine threonine kinase Akt exerts its anti apoptotic effects through several downstream targets , including the pro apoptotic Bc 1 2 family member Bad , Forkhead transcription factors , and the cyclic AMP response element binding protein ( CREB ) . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Basal phosphorylation of IRS 1 , PKB and ERK were unaffected whereas basal phosphorylation of CREB and FKHR were significantly increased ( 37 and 33 % , respectively ) with aging . desIGF 1 caused a significant decrease in plasma glucose concentrations in both young ( 53 % ) and old ( 44 % ) mice . desIGF 1 administration significantly increased the phosphorylation of IRS 1 in both young ( 104 % ) and old ( 89 % ) hepatic tissues . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Phosphatidylinositol 3 kinase is a central mediator of NMDA receptor signalling to MAP kinase ( Erk1 / 2 ) , Akt / PKB and CREB in striatal neurones . ^^^ We propose that NMDA receptor stimulation can activate Erk1 / 2 and Akt signalling pathways in a PI 3 kinase dependent manner which may target CREB in the nucleus . . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Neuroprotection by scatter factor / hepatocyte growth factor and FGF 1 in cerebellar granule neurons is phosphatidylinositol 3 kinase / akt dependent and MAPK / CREB independent . ^^^ These data show that both SF / HGF and FGF 1 protect cerebellar granule neurons against excitotoxicity with similar potency in a P 13 K / Akt dependent and MAP kinase / CREB independent manner . . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
In addition , lithium pretreatment suppresses glutamate induced loss of the activities of Akt , cyclic AMP response element binding protein ( CREB ) , c Jun N terminal kinase ( JNK ) and p 38 kinase . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
BDNF increased the phosphorylation of the forkhead transcription factor FKHRL 1 through activation of the phosphatidylinositol 3 kinase ( PI3K ) / Akt signaling pathway , and the phosphorylation of the cyclic AMP response element binding protein ( CREB ) through activation of extracellular signal regulated kinase1 / 2 ( ERK1 / 2 ) . ^^^ Overexpression of GSK3beta did not affect BDNF induced phosphorylation of Akt , ERK1 / 2 , or FKHRL 1 , but abolished CREB phosphorylation induced by BDNF . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Mitogenic and anti apoptotic signaling of GIP were dependent upon pleiotropic activation of protein kinase A ( PKA ) / cAMP regulatory element binder ( CREB ) , mitogen activated protein kinase ( MAPK ) and phosphatidylinositol 3 kinase ( PI 3 kinase ) / PKB signaling modules . ^^^ These interactions included : ( 1 ) a central role of tyrosine phosphorylation for stimulation of PKA / CREB , MAPK and PI 3 kinase / PKB , ( 2 ) inhibition of PKA / CREB by the MAPK pathway at the level of MAPK kinase 1 or downstream , ( 3 ) activation of MAPK signaling by PI 3 kinase and PKA at the level of extracellular signal regulated kinase 1 / 2 or upstream , and ( 4 ) activation of PKB by MAPK and PKA signaling at the level of PKB or upstream . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Neutrophils from PI 3 Kgamma / mice demonstrated decreased amounts of active , serine 473 phosphorylated Akt , phosphorylated CREB , and diminished nuclear translocation of NF kappaB . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Examination of signaling pathways upstream of CREB revealed a reduction in the active form of Akt . ^^^ Several end points of cytokine action including decreases in phospho CREB , phospho Akt , and BCl 2 levels and activation of caspase 9 were observed in isolated mouse islets . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Protein protection in FL cells was generalizable to downstream Akt targets , GSK3beta , P70S6 kinase , CREB , and other Hsp client proteins , including Raf 1 , cyclin dependent kinase 4 , and epidermal growth factor receptor . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
This blunted cAMP transcriptional effect was not due to different levels of cAMP generation , or altered expression of the cAMP target proteins CREB , Akt , CBP or ICER . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Under application of TNF alpha or emodin , increased PTEN phosphorylation and decreased phosphorylation of CK2 / Akt / cyclic AMP response element binding protein ( CREB ) , and CK 2 activity were significantly reversed by cilostazol ( approximately 1 100 microM ) , all of which were antagonized by iberiotoxin . 1 , 3 dihydro 1 [ 2 hydroxy 5 ( trifluoromethyl ) phenyl ] 5 ( trifluoromethyl ) 2H benzimidazol 2 one ( NS 1619 ) and ( 3S ) ( + ) ( 5 chloro 2 methoxyphenyl 1 , 3 dihydro 3 fluoro 6 ( trifluoromethyl ) 2H indol 2 one ( BMS 204352 ) maxi K channel openers significantly elevated CK 2 activities that were reversible by iberiotoxin . ^^^ It is suggested that the action of cilostazol promoting cell survival is ascribed to the maxi K channel opening coupled up regulation of CK 2 phosphorylation and down regulation of PTEN phosphorylation with resultant increased phosphorylation of Akt and CREB . . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Cilostazol significantly elevated phosphorylation levels of CK 2 , Akt , and cyclic AMP response element binding protein ( CREB ) in association with increased Bcl 2 in the ischemic area , whereas the elevated PTEN phosphorylation was significantly reduced , all of which were antagonized by iberiotoxin , a maxi K channel blocker , administered intracisternally 30 min before ischemia . ^^^ In conclusion , cilostazol ameliorates the neuronal damage by suppression of apoptotic cell death via the maxi K channel opening coupled up regulation of CK 2 phosphorylation and down regulation of PTEN phosphorylation with resultant increase in the Akt and CREB phosphorylation and increased Bcl 2 protein . . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Treatment with nonmyocyte conditioned media stimulated the phosphorylation of ERK , Akt , and cAMP response element binding protein ( CREB ) in myocytes . ^^^ MAPK kinase specific inhibitor PD 98059 , phosphatidylinositol 3 kinase Akt inhibitor LY 294002 , and CREB antisense oligonucleotide significantly blocked the antiapoptotic effect of nonmyocyte conditioned media . ^^^ Exogenous ET 1 mimicked nonmyocyte conditioned media mediated ERK and CREB phosphorylation and Bcl 2 protein increase but not Akt phosphorylation . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Research over the last few years has revealed that the hypoxia response in PC 12 cells involves the interactions of several signal transduction pathways ( Ca2+ / calmodulin dependent kinases , Akt , SAPKs , and MAPKs ) and transcription factors ( HIFs , CREB , and c fos / junB ) . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
We found that E stimulates each pathway at 24 h and that phosphorylation of CREB is dependent on both MAPK and CaMK activities , but less dependent on the Akt pathway . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Exposing neurones to the Src family tyrosine kinase inhibitor PP 2 , but not the inactive analogue PP 3 , inhibited NMDA receptor induced phosphorylation of ERK1 / 2 and Akt / PKB in a concentration dependent manner , and reduced cAMP response element binding protein ( CREB ) phosphorylation . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
To clarify the mechanisms of calcium signaling and its stimulation of gene expression via nAChRs in somata , we have investigated nAChR mediating calcium signaling mechanisms including phosphorylation of p42 / 44 MAP kinase ( ERK ) , CREB and Akt in PC12h cells . ^^^ Nicotine transiently activates phosphorylation of ERK , CREB and Akt . ^^^ Nicotine induces the activation of both PI 3 kinase / Act and ERK / CREB pathways via common pathways including non alpha 7 nAChRs , L type VSCC , CaM kinase and EGFR in PC12h cells , but Src family tyrosine kinases only participate in the pathway to activate Akt . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
In addition , phosphorylation of AKT and cyclic AMP responsive element binding protein ( CREB ) was reduced by GD 3 synthase overexpression . ^^^ Therefore , we conclude that GD 3 synthase has an apoptotic effect on ECV 304 cells through downregulation of Bcl 2 expression via dephosphorylation of AKT and CREB . . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
IGF 1 stimulation of the PI3K / Akt pathway phosphorylates three known Akt effectors : the survival transcription factor cyclic AMP response element binding protein ( CREB ) and the pro apoptotic effector proteins glycogen synthase kinase 3beta ( GSK 3beta ) and forkhead ( FKHR ) . ^^^ IGF 1 regulates survival at the nuclear level through accumulation of phospho Akt in DRG neuronal nuclei , increased CREB mediated transcription , and nuclear exclusion of FKHR . ^^^ These data suggest that IGF 1 prevents apoptosis in DRG neurons by regulating PI3K / Akt pathway effectors , including GSK 3beta , CREB , and FKHR , and by blocking caspase activation . . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
We compare the levels of the phopshorylated forms of CREB , Jun , and Akt in Jurkat T cells as detected by MLDot to those measured by a gel based assay . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Activation of Akt / PDK signaling in macrophages upon binding of receptor recognized forms of alpha 2 macroglobulin to its cellular receptor : effect of silencing the CREB gene . ^^^ We have now examined the participation of the PI 3 kinase / PDK / Akt / p70s6k signaling cascade in alpha2M * induced cellular proliferation and also studied the role of CREB in these events . ^^^ Exposure of cells to alpha2M * caused an approximately 2 fold increase in CREB and its phosphorylation at Ser 133 , phosphorylation of the regulatory subunit of PI 3 kinase , Akt phosphorylation at Ser 473 or Thr 308 , and phosphorylated 70s6k . ^^^ Silencing of the CREB gene with dsRNA homologous in sequence to the target gene , markedly reduced the levels of CREB mRNA activation of CREB , PI 3 kinase , Akt , and p70s6k in alpha2M * stimulated macrophages . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Beta estradiol prevents focal cerebral ischemic damages via activation of Akt and CREB in association with reduced PTEN phosphorylation in rats . ^^^ In line with these results , 17 beta estradiol significantly increased Akt and cyclic AMP response element binding protein ( CREB ) with increased Bcl 2 protein in the ischemic area , whereas the elevated the phosphatase and tensin homolog deleted from chromosome 10 ( PTEN ) phosphorylation was significantly reduced with decreased Bax protein and cytochrome c release . ^^^ Taken together , it is suggested that suppression of cerebral ischemic injury by 17 beta estradiol may be ascribed to the maxi K channel opening coupled downregulation of PTEN phosphorylation and upregulation of Akt and CREB phosphorylation with resultant increase in Bcl 2 protein and decrease in Bax protein and cytochrome c release . . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
A Raf , Akt , PKC , MEK , ERK , and transcription factors AP 1 , NF kappaB , and CREB are targets of both estrogen and ROS . ^^^ We provide four lines of evidence in support of our hypothesis that estrogen induced mitochondrial ROS stimulate redox sensor kinase A Raf , Akt or PKC , which , in turn , activate transcription factors NF kappaB , CREB , or AP 1 via the MEK / ERK pathway . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
We report perturbations in ERK1 / 2 , AKT , and CREB upon acute and chronic / repetitive low dose exposure in the hippocampus and frontal cortex of mice . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Furthermore , phosphorylation of CREB , one of the Akt substrates , was increased in TG 2 transfected cells and this phenomenon was confirmed by RT PCR analysis of several marker genes related with erythroid lineage in the absence of PI3K specific inhibitor , Wortmannin , indicating that PI3K / Akt signaling pathway also involved in the differentiation of the cell . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
In primed PC 12 cells , an early activation of protein kinase B ( Akt ) , representing a downstream target of phosphoinositol 3 ( PI 3 ) kinase , and a delayed phosphorylation of extracellular signal regulated kinases 1 and 2 ( ERK1 / 2 ) , and of transcription factor cAMP responsive element binding protein ( CREB ) was found . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
A series of distinct pathways are regulated by Akt that include the Forkhead family of transcription factors , GSK 3 beta , beta catenin , c Jun , CREB , Bad , IKK , and p 53 . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
CONCLUSIONS : These results indicate that a group 1 mGluR agonist induces phosphorylation of Akt , ERK1 / 2 and CREB in both CPu and NAc . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
These data demonstrate that both MEK 1 ERK1 / 2 and PI3K Akt signaling pathways are involved in CXCR 2 mediated neuroprotection and that multiple downstream signaling events , including RSKs , Bad , and CREB , are activated in this process . . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
In Ba / F3 Flt 3 cells , synergistic cell migration to FL plus CXCL 12 was associated with enhanced phosphorylation of mitogen activated protein kinase p42 / p44 ( MAPK ( p42 / p44 ) ) , cyclic adenosine monophosphate response element binding protein ( CREB ) , and Akt , and was partially inhibited by pretreatment of cells with selective inhibitors for MAPK ( p42 / p44 ) , protein kinase A ( PKA ) , or phosphatidylinositol 3 kinase ( PI 3 kinase ) , implicating these pathways in migration to FL plus CXCL 12 . ^^^ In contrast , prolonged exposure of CD34+ or Ba / F3 Flt 3 cells to FL down regulated CXCR 4 expression , inhibited CXCL 12 mediated phosphorylation of MAPK ( p42 / p44 ) , CREB , and Akt , and impaired migration toward CXCL 12 . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
CGS 21680 treatment of PC 12 cells transiently increased the phosphorylation of p 38 and JNK MAP kinases and Akt , as well as that of ATF 2 and CREB , reaching maximal levels at around 10 15 min of CGS 21680 treatment . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Increased phosphorylation of Akt and cyclic AMP responsive element binding protein ( CREB ) were detected in the hippocampus of Ames dwarf mice . ^^^ Our results suggest that increase in hippocampal GH and IGF 1 protein expression and subsequent activation of PI3K / Akt CREB signal transduction cascade might contribute to the maintenance of cognitive function and is likely to be responsible for the integrity of neuronal structure , and maintenance of youthful levels of cognitive function in these long lived mice during aging . . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
On the other hand , during induction of ischemic tolerance , Akt activity gradually and persistently increased in the CA 1 neurons with transient increase in CREB phosphorylation . ^^^ Inhibition of Akt activity with wortmannin or CREB DNA binding with CRE decoy injection resulted in failure of generation of ischemic tolerance . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Extracellular signal regulated kinases ( ERKs ) , protein kinase B ( PKB ) , and adenosine 3 ' : 5 ' cyclic monophosphate response element binding protein ( CREB ) are messenger molecules that play important roles in neuronal plasticity and survival . ^^^ This study was undertaken to examine the effects of acute ethanol on ERK , PKB , and CREB activation in the brain . ^^^ RESULTS : In cortical cultures , ethanol ( 100 mM ) significantly reduced activity dependent activation of phospho ERK , phospho PKB , and phospho CREB by approximately 50 % . ^^^ CONCLUSION : The results demonstrate that acute ethanol inhibits ERK / PKB / CREB signaling in brain . ^^^ Furthermore , the lack of effect of MK 801 suggests that inhibition of NMDA receptors is unlikely to play a major role in binge ethanol inhibition of ERK / PKB / CREB signaling in vivo . . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Dibutyryl cAMP increased phosphorylation of Akt and CREB , both of which were reversed by H 89 , wortmannin and the Akt inhibitor SH 6 . ^^^ These findings suggest that elevation of endogenous cAMP effectively prevents radiocontrast nephropathy through activation of A kinase / PI 3 kinase / Akt followed by CREB phosphorylation and enhanced expression of Bcl 2 . . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Furthermore , elevated Kalirin expression resulted in catalytic activation of TrkA , as demonstrated by in vitro kinase assays and increased NGF stimulated cellular activation of Rac , Mek , and CREB . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
These cell lines differed from one another in two Bcl 2 regulating pathways : adhesion through alphavbeta 1 failed to activate Akt , allowing forkhead to suppress Bcl 2 transcription , whereas alpha5Deltacbeta1 did not activate NF kappaB and CREB , presumably because CaMK 4 was not activated . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Activation of several cell death programs represented by Fas ligand , FADD ( Fas Associated Death Domain / Mort1 ) and the caspase cascade ( caspase 8 and 3 ) and survival programs represented by phosphorylated protein kinase B ( PKB / Akt ) , Bcl 2 associated death domain ( BAD ) , and cAMP responsive element binding protein ( CREB ) were examined using immunohistochemistry and Western blotting . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Immunoblot analysis revealed that phosphorylation signals , including protein kinase B ( Akt / PKB ) , glycogen synthase kinase 3beta ( GSK 3beta ) , and cyclic adenosine monophosphate response element binding protein ( CREB ) were reduced immediately after ECS treatment . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Coordinate regulation of forskolin induced cellular proliferation in macrophages by protein kinase A / cAMP response element binding protein ( CREB ) and Epac 1 Rap1 signaling : effects of silencing CREB gene expression on Akt activation . ^^^ Silencing of CREB gene expression by RNA interference prior to forskolin treatment not only decreased CREB protein and its phosphorylation at Ser 133 , but also phosphorylation of Akt at Ser 473 , and Thr 308 . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
LPA induced transient ( 10 min ) phosphorylations of ERK 1 / 2 , Akt and the transcription factor CREB . ^^^ The LPA induced phosphorylation of ERK 1 / 2 and CREB was blocked by inhibition of PI3K , PKC and MEK , but that of Akt was only inhibited by wortmannin , the PI3K inhibitor . ^^^ Inhibition of Rho kinase or NHE 1 did not reduce the LPA induced phosphorylation of ERK , Akt or CREB . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
L 59 activated Src ( a known substrate of LAR ) , FAK and TrkB and also activated downstream signalling intermediates including PKC , ERK , AKT and CREB . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
IGF 1 protects cortical neurons against ceramide induced apoptosis via activation of the PI 3K / Akt and ERK pathways ; is this protection independent of CREB and Bcl 2 . ^^^ In non neuronal cells , Akt phosphorylates and activates the transcription factor CREB , implicated in the transcription of the anti apoptotic bcl 2 gene . ^^^ In consequence , we demonstrated that IGF protects neurons against ceramide induced apoptosis and that IGF 1 protection involves the PI 3K / Akt and ERK pathways ; this protection may be independent of CREB and Bcl 2 . . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Pretreatment of RAW264 . 7 cells with LPS led to the activation of mitogen activated protein kinase ( MAPK ) s [ p 38 , extracellular signal regulated kinase ( ERK ) 1 / 2 , c Jun NH 2 terminal kinase ( JNK ) 1 / 2 ] and Akt , together with degradation of the inhibitor of nuclear factor kappaB ( IkappaB ) alpha protein and nuclear translocation of nuclear factor ( NF ) kappaB p 65 , and the resultant activation of activator protein ( AP ) 1 , NF kappaB , and cAMP responsive element binding protein ( CREB ) transcription factors . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
In the present study , we examined how the cell survival signaling via cyclic AMP responsive element binding protein ( CREB ) and Akt , and the cell death signaling via cystein proteases , calpain and caspase 3 , are involved in oxygen glucose deprivation ( OGD ) followed by reoxygenation ( OGD / reoxygenation ) induced cell death in nerve growth factor ( NGF ) differentiated PC 12 cells . ^^^ After 4 hr of OGD followed by 3 hr of reoxygenation , dephosphorylation of phosphorylated CREB ( pCREB ) , but not phosphorylated Akt ( pAkt ) , was induced . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
DHA consumption blocked DON induced phosphorylation of the CREB kinase AKT . ^^^ Inhibition of AKT suppressed both CREB / ATF1 phosphorylation and IL 6 transcription . ^^^ These data suggest that DHA consumption suppresses DON induced IL 6 transcription in macrophages in part by interfering with AKT dependent phosphorylation and subsequent binding of CREB / ATF1 to the IL 6 promoter . . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Cilostazol suppressed TNF alpha induced decrease in viability of SK N SH ( human neuroblastoma ) cells and HCN 1A ( human cortical neuron ) cells in association with decrease in PTEN phosphorylation and increase in Akt / CREB phosphorylation with suppression of DNA fragmentation , all of which were antagonized by iberiotoxin , a maxi K ( + ) channel blocker . ^^^ Thus , it was suggested that the action of cilostazol to promote cell survival was ascribed to the maxi K channel opening coupled upregulation of CK 2 phosphorylation and downregulation of PTEN phosphorylation with resultant increased phosphorylation of Akt and CREB . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Pretreatment of RAW264 . 7 macrophages with LPS led to the activation of mitogen activated protein kinases ( MAPKs ) and Akt , together with the degradation of IkappaB alpha protein , and the resultant activation of the AP 1 , NF kappaB , and CREB transcription factors . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Overexpression of dominant negative Akt attenuated agonist induced phosphorylation of BAD , but not that of ERK1 / 2 and CREB . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Platelet derived growth factor BB induces nuclear export and proteasomal degradation of CREB via phosphatidylinositol 3 kinase / Akt signaling in pulmonary artery smooth muscle cells . ^^^ Inhibition of these pathways blocked SMC proliferation in response to PDGF , but only inhibition of PI 3 kinase or its effector , Akt , blocked PDGF induced CREB loss . ^^^ We conclude that PDGF stimulates nuclear export and proteasomal degradation of CREB in SMCs via PI 3 kinase / Akt signaling . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
Akt and CREB mediated prostate cancer cell proliferation inhibition by Nexrutine , a Phellodendron amurense extract . ^^^
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
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Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16220 and P31749	Pubmed	SVM Score :0.0
NA