| Interacting proteins: P15976 and P31749 |
Pubmed |
SVM Score :0.0 |
| Restoration of GATA 1 activity induced G 1 cell cycle arrest coincident with repression of c Kit and its downstream effectors Vav 1 , Rac 1 , and Akt . ^^^ |
|
| Interacting proteins: P15976 and P31749 |
Pubmed |
SVM Score :0.0 |
| Phosphatidylinositol 3 kinase / Akt induced by erythropoietin renders the erythroid differentiation factor GATA 1 competent for TIMP 1 gene transactivation . ^^^ We found that Akt directly phosphorylates the transcription factor GATA 1 at serine 310 and that this site specific phosphorylation is required for the transcriptional activation of the TIMP 1 promoter . ^^^ |
|
| Interacting proteins: P15976 and P31749 |
Pubmed |
SVM Score :0.0 |
| Erythropoietin stimulates phosphorylation and activation of GATA 1 via the PI 3 kinase / AKT signaling pathway . ^^^ The PI 3 kinase / AKT signaling pathway is identified as a mediator of Epo induced phosphorylation of GATA 1 . ^^^ AKT serine threonine kinase phosphorylates GATA 1S310 in vitro and in erythroid cells and enhances GATA 1 transcriptional activity . ^^^ These data demonstrate that EpoR signaling phosphorylates GATA 1 and modulates its activity via the PI 3 kinase / AKT signaling pathway . . ^^^ |
|
| Interacting proteins: P15976 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|