| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| In Rat1a fibroblasts , activated Akt did not alter Bcl 2 or Bcl 10 ( L ) expression but inhibited Ced3 / ICE like activity . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| We have previously shown that Akt inhibits the activity of DEVD targeted caspases without changing the steady state levels of Bcl 2 and Bcl 10 ( L ) . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| Activation of PI3K leads to enhanced activity of PKB and increased levels of the anti apoptotic protein Bcl 10 ( L ) . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| Both thymocytes and T cells overexpressing gag PKB displayed elevated levels of the antiapoptotic molecule Bcl 10 ( L ) . ^^^ Our data highlight a physiological role for PKB in promoting survival of DP thymocytes and mature T cells , and provide evidence for the direct association of three major survival molecules ( PKB , Bcl 10 ( L ) , and NF kappaB ) in vivo in T lymphocytes . . ^^^ Protein kinase B regulates T lymphocyte survival , nuclear factor kappaB activation , and Bcl 10 ( L ) levels in vivo . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| Akt inhibits apoptosis by phosphorylating Bad , thus promoting its binding to and blockade of the activity of the cell survival factor Bcl 10 . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| The p 54 isoform of c jun N terminal kinase stress activated kinase ( JNK SAPK ) coimmunoprecipitated with Akt from me 5 macrophages , and treatment of me 5 cells with the specific phosphatidylinositol 3 kinase inhibitor LY 294002 decreased cell survival , Akt and JNK kinase activities , ets 2 phosphorylation , and Bcl 10 mRNA expression . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| Consistent with this , overexpressing active Akt rescues cells from apoptosis without altering expression levels of endogenous Bcl 2 , Bcl 10 , or Bax . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| Akt activation by proapoptotic stimuli lay upstream of mitochondria , because neither caspase inhibitors nor overexpression of Bcl 2 or Bcl 10 ( L ) could prevent it . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| The effects of PI3K inhibition were reversed by the ectopic expression of constitutively activated Akt 1 or Bcl 10 ( L ) . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| Tumor SN , N oleoylethanolamine , or PDMP suppressed Akt , NF kappaB , and bcl 10 ( L ) in DC , suggesting that the accumulation of ceramide impedes PI3K mediated survival signals . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| Our data indicated that sublytic C5b 9 rescued Schwann cell from apoptosis via activation of PI 3 kinase Akt , BAD phosphorylation on Ser 136 and increased expression of Bcl 10 ( L ) . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| Expression of Akt did not alter the levels of Bax , Bcl 2 , Bcl 10 ( L ) , or phosphorylated JNK under the conditions used , suggesting that there were alternative mechanisms for Akt in the suppression of Bax translocation . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| Correlating with these results , T 2 cells robustly induced expression of the cell cycle regulator cyclin D 2 and the antiapoptotic factors A1 / Bfl 1 and Bcl 10 ( L ) and exhibited activation of Akt . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the known downstream modulators of the Akt / PI3K cell survival pathway , Bcl 10 ( L ) , and BAD proteins showed decreased expression after I3C treatment . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| Furthermore , our study using specific inhibitors reveals that the extended survival of B 1 cells in culture is not due to the constitutive activation of ERK ; nor is it due to Akt signaling or Bcl 10 ( L ) up regulation , since these are not induced in B 1 cells . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| To analyze the mechanisms of the apoptotic activity of Cl F araA , we sought to determine the effects of the drug on the levels of Bcl 2 family proteins ( Bcl 2 , Bcl 10 ( L ) , Mcl 1 , Bax , Bak ) and cell survival signals via Akt . ^^^ Western blot analysis revealed that Cl F araA induced a dose and time dependent downregulation of Bcl 10 ( L ) and Mcl 1 proteins , and a dose and time dependent dephosphorylation of Akt and its downstream effectors ( Bad , FKHRL 1 ) , particularly in vivo . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| The release of cytochrome c is the central gate in turning on / off apoptosis , and is regulated by the interaction of proapoptotic proteins , including Bid , Bax and Bak , and antiapoptotic proteins including Bcl 2 and Bcl 10 ( L ) , and a specific class of inhibitors of apoptosis proteins ( IAPs ) including Akt , survivin , and heat shock proteins . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| Interestingly , the EMT process confers them resistance to the apoptotic effect of TGF beta , with cells showing higher levels of active AKT and Bcl 10 ( L ) than fetal hepatocytes . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| Bcl 10 ( L ) and Akt cooperate to promote leukemogenesis in vivo . ^^^ Relative resistance to cell death following IL 3 withdrawal can be conferred by either overexpression of the Bcl 10 ( L ) apoptotic inhibitor , or constitutive activation of the serine / threonine kinase Akt . ^^^ The ability of Bcl 10 ( L ) or a constitutively active myristylated Akt to promote leukemic transformation of FL5 . 12 cells was compared in athymic nu ( + ) / nu ( + ) mice . ^^^ Bcl 10 ( L ) and Akt appeared to function cooperatively in this model , enhancing rapid clonal outgrowth in vivo relative to Akt alone . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| Further downstream in the signal transduction cascade , EPO engages diverse cellular pathways such as those involving Janus kinase 2 , signal transducers and activators of transcription ( STATs ) , mitogen activated protein kinases ( MAPKs ) , Bcl 10 ( L ) , protein kinase B , protein kinase C , and cysteine proteases to provide `` plasticity ' ' to vascular systems through highly conserved mechanisms . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| Moreover , TIMP 1 enhances specific phosphorylation of both Akt and Bad ( Bcl 2 / Bcl 10 ( L ) antagonist , causing cell death ) in a PI 3 kinase dependent manner and , besides , controls the level of the anti apoptotic protein Bcl 10 ( L ) . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| The anti apoptotic role of Akt suggested by these experiments was tested by overexpression of constitutively active Akt , which blocked dexamethasone induced apoptosis and elevated IAP 2 but not Bcl 10 ( L ) levels in a mature T cell line . ^^^ Thus , IL 7 regulates IAP 2 expression and inhibits dexamethasone induced apoptosis by activating Akt via PI3K dependent signaling , but regulates Bcl 10 ( L ) expression via a PI3K independent pathway in mature T cells . . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| It induced the early phase apoptosis in A 549 cells via the Bcl 10 ( L ) down regulation , and that of the late phase through up regulation of Bax expression as well as inhibition of Akt / PKB activation . . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| In addressing possible downstream effectors of EGFR through activated Akt , we detected significant upregulation of Bcl 10 ( L ) protein , suggesting this pro survival protein is a target of Akt in MMECs . ^^^ By using pharmacological inhibitors of PI 3 K / Akt and MEK / Erk together with dominant negative Akt and Erk 1 we observed the decrease in Bcl 10 ( L ) protein . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| Insulin like growth factor 1 receptor enhances invasion and induces resistance to apoptosis of colon cancer cells through the Akt / Bcl 10 ( L ) pathway . ^^^ Moreover , the overexpression of IGF 1 R in these cells was associated with IGF 1 R induced activation of Akt and up regulation of the antiapoptotic protein Bcl 10 ( L ) . ^^^ We also show that Akt pathway mediates IGF 1 R induced Bcl 10 ( L ) expression at transcriptional level . ^^^ Our data demonstrate , for the first time , that IGF 1 R / Akt / Bcl 10 ( L ) pathway may contribute to a more aggressive malignant phenotype , in a subset of colorectal cancers . . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| These events were associated with down regulation of antiapoptotic members of the Bcl 2 family , Bcl 2 and Bcl 10 ( L ) , and dephosphorylation of the serine / threonine protein kinase Akt . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| In particular , it has been shown that PECAM 1 binds to different kinases and phosphatases , including the phosphatidylinositide 3 kinase that phosphorylates Akt , which , in turn can upregulate transcription and function of antiapoptotic proteins , such as Bcl 2 and Bcl 10 or A 1 , responsible for the rescue from mitochondrial apoptosis . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| Intrastriatal grafting of a BDNF secreting cell line counter regulated p AKT , Bcl 2 , Bcl 10 ( L ) and Bax protein levels , prevented changes in the heterodimerization between Bax and pro survival proteins , and blocked caspase 3 activation induced by excitotoxicity . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| Current work has identified exciting pathways , such as the Wnt pathway and the serine threonine kinase Akt , as central modulators that oversee cellular apoptosis and their downstream substrates that include Forkhead transcription factors , glycogen synthase kinase 3beta , mitochondrial dysfunction , Bad , and Bcl 10 ( L ) . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| These findings suggest that C1P blocks apoptosis , at least in part , by stimulating the PI 3 K / PKB / NF kappaB pathway and maintaining the production of antiapoptotic Bcl 10 ( L ) . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| This study investigated whether estradiol modulates the anti apoptotic signal through the activation of Akt and its downstream targets , including Bad , Bcl 10 ( L ) , and 14 3 3 . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| We examined the effects of t PA ( 10 mg / kg , i . v . ) , administered alone or in combination with melatonin ( 4 mg / kg , i . p . ) , on ischemic injury , inducible nitric oxide synthase ( iNOS ) expression as well as Akt , Bcl 10 ( L ) and caspase 3 signaling following 90 min of intraluminal middle cerebral artery ( MCA ) occlusion in mice . t PA , delivered immediately after reperfusion onset , increased infarct volume at 24 hr after MCA occlusion , in accordance with previous findings . ^^^ Western blots revealed that t PA decreased phosphorylated Akt levels , but did not influence Bcl 10 ( L ) expression and caspase 3 activity in ischemic brain lysates . ^^^ Co treatment with melatonin restored phosphorylated Akt levels , increased Bcl 10 ( L ) expression and reduced caspase 3 activity . ^^^ |
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| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| Bcl 10 is up regulated by NF kappaB and phosphorylated by Akt 1 and then complexes with Bcl 3 to enter the nucleus . ^^^ This study also demonstrates that Akt 1 , activated by TNFalpha , phosphorylates Bcl 10 at Ser 218 and Ser 231 and that phosphorylated Bcl 10 subsequently complexes with Bcl 3 to enter the nucleus . ^^^ Either inhibition of Akt 1 or depletion of Bcl 3 blocks Bcl 10 nuclear translocation . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| In the study of the molecular mechanism of this phenomenon , it was found that GnTV AS reduced the expressions of anti apoptotic proteins , such as phosphorylated protein kinase B and phosphorylated Bad as well as Bcl 2 and Bcl 10 ( L ) , and elevated those of pro apoptotic proteins , including Bax , full length caspase 3 and its activated fragments as well as anti oncoprotein p 53 . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| Finally , we provide evidence for a physical and functional interaction between Akt and CARMA and for Akt dependent phosphorylation of Bcl 10 . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| For instance , the cell signaling pathways inhibited by curcumin alone include NF kappaB , AP 1 , STAT 3 , Akt , Bcl 2 , Bcl 10 ( L ) , caspases , PARP , IKK , EGFR , HER 2 , JNK , MAPK , COX 2 , and 5 LOX . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| These morphological differences were also coupled with biochemical data showing a distinct tyrosine phosphorylation based signaling , an altered localization of beta catenin , MAPK , and AKT activation , as well as an increased expression in T84SF cells of Bcl 10 ( L ) , a major regulator of apoptosis . ^^^ |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|