| Interacting proteins: O95988 and P31749 |
Pubmed |
SVM Score :0.0 |
| The members of the TCL 1 proto oncogene family ( TCL 1 , MTCP 1 , and TCL1b ) bind to Akt 1 , increasing its phosphorylation status and kinase activity . ^^^ Here we show that , in contrast to Akt 1 and Akt 2 , which bind to all members of the TCL 1 family , Akt 3 specifically interacts with TCL 1 but not with MTCP 1 or TCL1b . ^^^ This association is functional , as the presence of TCL 1 but not MTCP 1 or TCL1b increased Akt 3 kinase activity in in vitro kinase assays . ^^^ Functional specificity is determined by the Akt pleckstrin homology domain as chimeric Akt 1 , where Akt 1 PH domain was replaced by that of Akt 3 was no longer able to interact with MTCP 1 or TCL1b and its kinase activity was solely enhanced by TCL 1 . ^^^ |
|
| Interacting proteins: O95988 and P31749 |
Pubmed |
SVM Score :0.0 |
| This region was found in other members of the TCL 1 oncoprotein family , such as TCL1b and MTCP 1 , and suggested a conserved , novel AKT binding domain . ^^^ |
|
| Interacting proteins: O95988 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95988 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95988 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95988 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|