| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| BIM 23056 was an antagonist at sst 3 receptors ( antagonist binding constant pKB = 6 . 33 ) , but not at other receptors . ^^^ |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| Inhibition of Akt increased the FKHR / Bim response and DNA fragmentation within the normally resistant cortex . ^^^ |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| Overexpression of SK mediated survival primarily through the activation of the phosphatidyl inositol 3 kinase ( PI 3K ) / protein kinase B ( Akt / PKB ) pathway and an associated up regulation of the antiapoptotic protein B cell lymphoma gene 2 ( Bcl 2 ) and down regulation of the proapoptotic protein bisindolylmaleimide ( Bcl 2 interacting mediator of cell death ; Bim ) . ^^^ |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| BIM 23056 behaved as an antagonist on SRIF 14 induced total [ 3H ] IPx accumulation with a pKB ( negative logarithm of antagonist binding constant ) of 6 . 74 at hsst 3 receptors , and of 6 . 94 at hsst 5 receptors . ^^^ |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| Furthermore , hematopoietic stem cells isolated from Bim / mice exhibited reduced levels of apoptosis upon inhibition of PI3K / PKB signaling . ^^^ |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| Finally , adenoviral mediated expression of dominant negative AKT activated FKHRL 1 and induced expression of Bim . ^^^ These data suggest that IGF 1 signaling via AKT promotes survival of cerebellar granule neurons by blocking the FKHRL 1 dependent transcription of Bim , a principal effector of the intrinsic death signaling cascade . . ^^^ |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| The ability of deltaRaf 1 : ER * to repress Bim ( EL ) expression required the ERK pathway but was independent of the PI3K > PDK > PKB pathway . ^^^ |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| Akt regulated forkhead transcription factors are involved in the control of the expression of both the cyclin dependent kinase ( cdk ) inhibitor p 27 ( Kip 1 ) and proapoptotic Bim protein . ^^^ |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| Akt1 / Akt2 and mammalian target of rapamycin / Bim play critical roles in osteoclast differentiation and survival , respectively , whereas Akt is dispensable for cell survival in isolated osteoclast precursors . ^^^ To investigate the function of Akt 1 , Akt 2 , mTOR , and Bim , we employed a retroviral system for delivery of small interfering RNA into cells . ^^^ In addition , we found that mTOR is downstream of phosphatidylinositol 3 kinase ( but not Akt ) and that macrophage colony stimulating factor regulates Bim expression through mTOR activation for cell survival . ^^^ |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| Because apoptosis is abnormally reduced in bim / mast cells , these data provide evidence that Akt mediated inhibition of FOXO3a and its transcription target Bim provides an important mechanism by which SCF acts to prevent apoptosis in mast cells . . ^^^ |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| Protection may arise through the inhibition of the pro apoptotic protein Bim , which is normally repressed by a PKB dependent mechanism . ^^^ Here we show that PTEN / immortalized mouse embryonic fibroblasts ( MEFs ) exhibit elevated PKB phosphorylation and are resistant to serum withdrawal induced death , but exhibit normal Bim expression following withdrawal of serum . ^^^ |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| Inhibition of Rac GTPase triggers a c Jun and Bim dependent mitochondrial apoptotic cascade in cerebellar granule neurons . ^^^ These results indicate that Rac acts downstream of integrins and growth factors to promote neuronal survival by repressing c Jun / Bim mediated mitochondrial apoptosis . . ^^^ |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| The appearance of multiple , phosphorylated species of Bim ( EL ) correlated with Akt , and not ERK , activation . ^^^ The PI3K inhibitor , LY 294002 , blocked IL 3 stimulated Akt activity and partially blocked Bim ( EL ) phosphorylation . ^^^ In vitro kinase assays showed that recombinant Akt could directly phosphorylate a GST Bim ( EL ) fusion protein and identified the Akt phosphorylation site in the Bim ( EL ) domain as Ser ( 87 ) . ^^^ We propose that Ser ( 87 ) of Bim ( EL ) is an important regulatory site that is targeted by Akt to attenuate the pro apoptotic function of Bim ( EL ) , thereby promoting cell survival . . ^^^ |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| Protein phosphatase 2A regulates bim expression via the Akt / FKHRL1 signaling pathway in amyloid beta peptide induced cerebrovascular endothelial cell death . ^^^ Akt upregulation by adenoviral gene transfer inhibited Abeta induced FKHRL 1 activation and bim induction . ^^^ Suppression of PP2A activity by RNA interference or a specific inhibitor , okadaic acid , effectively suppressed Abeta induced Akt inactivation and FKHRL 1 activation , leading to an attenuation of bim expression and cell death in CECs . ^^^ These results implicate PP2A as an early regulator of Abeta induced bim expression and CEC apoptosis via the Akt / FKHRL1 signaling pathway . ^^^ |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| Group 1 metabotropic receptor neuroprotection requires Akt and its substrates that govern FOXO3a , Bim , and beta catenin during oxidative stress . ^^^ Closely coupled to the robust neuroprotection by mGluRI activation are the inhibitory phosphorylation and prevention of caspase 3 cleavage of the Forkhead transcription factor FOXO3a , the down regulation of Bim expression , and the protection of beta catenin by Akt 1 against phosphorylation and degradation to promote its translocation from the cytoplasm to the nucleus and allow it to assist with a `` pro survival ' ' cellular program . ^^^ |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| This applies to tumor suppressors of the Bax / Bcl 2 family ( Bax , Bad , Bid , Bim ) , several protein kinases ( Akt , ASK 1 , hexokinase ) , p 53 , NF kappaB , and nuclear orphan receptors such as TR3 / Nur77 . ^^^ |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| Our results suggest that Puma , together with another BH 3 only member , Bim , function as FOXO3a downstream targets to mediate a stress response when PI3K / Akt signaling is down regulated . . ^^^ |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43521 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|