| Interacting proteins: O14788 and P31749 |
Pubmed |
SVM Score :0.0 |
| The RANKL stimulated phosphorylation of Akt , a downstream target of PI 3 kinase , and that of ERK were observed . ^^^ |
|
| Interacting proteins: O14788 and P31749 |
Pubmed |
SVM Score :0.0 |
| M CSF signals to Akt , while RANKL , like TNFalpha , activates NF kappaB . ^^^ |
|
| Interacting proteins: O14788 and P31749 |
Pubmed |
SVM Score :0.0 |
| M CSF and RANKL activate the ERK , Akt , and NF kappaB signal transduction pathways , and SCOH suppressed this activation . ^^^ |
|
| Interacting proteins: O14788 and P31749 |
Pubmed |
SVM Score :0.0 |
| The mammary gland defect in female opgl / mice is characterized by enhanced apoptosis and failures in proliferation and PKB activation in lobulo alveolar buds that can be reversed by recombinant OPGL treatment . ^^^ |
|
| Interacting proteins: O14788 and P31749 |
Pubmed |
SVM Score :0.0 |
| RANKL dose dependently stimulated transient activation of Akt before activation of PTEN , consistent with a role for PTEN in decreasing Akt activity . ^^^ PTEN overexpression blocked RANKL activated Akt stimulated survival and osteopontin stimulated cell migration while a dominant negative PTEN increased the actions of RANKL and OPN . ^^^ |
|
| Interacting proteins: O14788 and P31749 |
Pubmed |
SVM Score :0.0 |
| Blocking MEK , AKT , or NFkappaB activity resulted in apoptosis of many , but not all , of the osteoclasts in purified marrow derived osteoclasts , marrow derived osteoclasts co cultured with stromal cells , and spleen derived osteoclasts maintained with RANKL and M CSF . ^^^ |
|
| Interacting proteins: O14788 and P31749 |
Pubmed |
SVM Score :0.0 |
| RANKL stimulation of RANK / TRAF6 signaling increases nuclear factor kappaB ( NFkappaB ) nuclear translocation and activates the Akt / PKB cell survival pathway . ^^^ |
|
| Interacting proteins: O14788 and P31749 |
Pubmed |
SVM Score :0.0 |
| RANKL regulates endothelial cell survival through the phosphatidylinositol 3 ' kinase / Akt signal transduction pathway . ^^^ RANKL elicited the phosphorylation of the serine threonine kinase Akt at Ser 473 in a PI 3 ' kinase dependent manner . ^^^ The expression of a dominant negative form of Akt or pretreatment of Akt specific inhibitor in endothelial cells reversed the RANKL induced survival effect . ^^^ These findings indicate that RANK , in response to the paracrine stimulus of RANKL , may play an important role in maintaining endothelial cell integrity through the PI 3 ' kinase / Akt signal transduction pathway . . ^^^ |
|
| Interacting proteins: O14788 and P31749 |
Pubmed |
SVM Score :0.0 |
| In addition , SHP 1 regulated RANKL stimulated tyrosine phosphorylation of p 85 subunit of phosphatidylinositol 3 kinase and the phosphorylation of Akt . ^^^ |
|
| Interacting proteins: O14788 and P31749 |
Pubmed |
SVM Score :0.0 |
| A casein kinase 1 ( CKI ) inhibitor markedly suppressed the inhibitory effect of r 4 1BB on M CSF / RANKL induced osteoclast formation , suggesting that CKI might be involved in 4 1BB / 4 1BBL reverse signaling . r 4 1BB showed no effects on M CSF or RANKL induced phosphorylation of 1 kappaB , ERK1 / 2 , p 38 , or JNK , whereas RANKL induced phosphorylation of Akt , a downstream target of phosphatidylinositol 3 kinase ( PI3K ) , was completely abolished by r 4 1BB , suggesting that 4 1BB / 4 1BBL reverse signaling may interfere with PI3K / Akt pathway . r 4 1BB also abolished RANKL mediated induction of nuclear factor of activated T cells 2 . ^^^ |
|
| Interacting proteins: O14788 and P31749 |
Pubmed |
SVM Score :0.0 |
| RANKL activated the ERK , Akt , and NF kappaB signal transduction pathways in osteoclast precursor cells , and tanshinone IIA suppressed this activation . ^^^ |
|
| Interacting proteins: O14788 and P31749 |
Pubmed |
SVM Score :0.0 |
| Pretreatment of osteoclasts with the antioxidants N acetyl l cystein and glutathione reduced RANKL induced Akt , NF kappaB , and ERK activation . ^^^ |
|
| Interacting proteins: O14788 and P31749 |
Pubmed |
SVM Score :0.0 |
| RANKL induced second messenger signaling ( AKT and p 38 MAP Kinase phosphorylation ) was completely blocked by 100 microM suramin . ^^^ |
|
| Interacting proteins: O14788 and P31749 |
Pubmed |
SVM Score :0.0 |
| In addition , RAW267 . 5 cells treated with BSP and RANKL exhibited decreased activation of the proapoptotic Jun N terminal kinase pathway and increased activation of anti apoptotic AKT pathway than cells treated with RANKL or BSP alone . ^^^ |
|
| Interacting proteins: O14788 and P31749 |
Pubmed |
SVM Score :0.0 |
| We show that PKB activity is a critical downstream component of PDK 1 in mediating translation of cystatin C , RANKL , and Rab11a , whereas mTOR activity is less important for effective translation of these targets . . ^^^ |
|
| Interacting proteins: O14788 and P31749 |
Pubmed |
SVM Score :0.0 |
| We also investigated the role of these motifs in activating Akt / protein kinase B ( PKB ) , which has been implicated in RANKL induced osteoclast survival . ^^^ Our data revealed that RANKL only stimulates AFX / FOXO4 phosphorylation , indicating that AFX / FOXO4 is a key downstream target activated by Akt / PKB to modulate osteoclast survival . ^^^ |
|
| Interacting proteins: O14788 and P31749 |
Pubmed |
SVM Score :0.0 |
| RANKL induced phosphorylation of ERK , p 38 , and NF kappaB was not suppressed by HbR , but that of Akt was markedly suppressed . ^^^ |
|
| Interacting proteins: O14788 and P31749 |
Pubmed |
SVM Score :0.0 |
| TRANCE , a TNF family member , activates Akt / PKB through a signaling complex involving TRAF 6 and c Src . ^^^ Here , we demonstrate that TRANCE activates the antiapoptotic serine / threonine kinase Akt / PKB through a signaling complex involving c Src and TRAF 6 . ^^^ A deficiency in c Src or addition of Src family kinase inhibitors blocks TRANCE mediated PKB activation in osteoclasts . c Src and TRAF 6 interact with each other and with TRANCE R upon receptor engagement . ^^^ These results define a mechanism by which TRANCE activates Src family kinases and PKB and provide evidence of cross talk between TRAF proteins and Src family kinases . . ^^^ |
|
| Interacting proteins: O14788 and P31749 |
Pubmed |
SVM Score :0.0 |
| A positive regulatory role for Cbl family proteins in tumor necrosis factor related activation induced cytokine ( trance ) and CD40L mediated Akt activation . ^^^ We recently demonstrated that TRANCE activates Akt via a mechanism involving TRANCE receptor ( TRANCE R ) / RANK , TRAF 6 , and c Src . ^^^ TRANCE and CD40L mediated Akt activation is defective in Cbl b / dendritic cells , and CD40L mediated Akt activation is defective in c Cbl / B cells . ^^^ |
|
| Interacting proteins: O14788 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14788 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14788 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14788 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14788 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14788 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14788 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|