| Interacting proteins: P31269 and P40424 |
Pubmed |
SVM Score :1.1666905 |
| Hoxa 9 , Meis 1 and Pbx 1 proteins have been shown to physically interact with each other , as Hoxa 9 cooperatively binds consensus DNA sequences with Meis 1 and with Pbx 1 , while Meis 1 and Pbx 1 form heterodimers in both the presence and absence of DNA . 1.1666905^^^ |
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| Interacting proteins: P31269 and P40424 |
Pubmed |
SVM Score :0.0 |
| We find HoxA 9 mediated CYBB transcription requires Pbx 1 but is inhibited by Meis 1 . ^^^ |
|
| Interacting proteins: P31269 and P40424 |
Pubmed |
SVM Score :0.0 |
| Meis 1 and Pbx 1 interaction domain swapping mutants are dysfunctional separately , but restore the full oncogenic activity of Meis 1 when cotransduced in primary cells engineered to overexpress Hoxa 9 , thus implying a modular nature for PIM in Meis 1 accelerated transformation . ^^^ |
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| Interacting proteins: P31269 and P40424 |
Pubmed |
SVM Score :0.0 |
| In human leukemias , a HOX gene ( HOXA 9 ) and two non HOX homeobox genes ( PBX 1 and HOX 11 ) are involved in chromosomal translocations . ^^^ |
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| Interacting proteins: P31269 and P40424 |
Pubmed |
SVM Score :0.0 |
| In this report , we demonstrate that HOXB 3 , which is highly divergent from HOXA 9 , also genetically interacts with MEIS 1 , but not with PBX 1 , in generating AML . ^^^ |
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| Interacting proteins: P31269 and P40424 |
Pubmed |
SVM Score :0.0 |
| Structure of HoxA 9 and Pbx 1 bound to DNA : Hox hexapeptide and DNA recognition anterior to posterior . ^^^ We report here the 1 . 9 A resolution structure of a posterior HOX protein , HoxA 9 , complexed with Pbx 1 and DNA , which reveals that the posterior Hox hexapeptide adopts an altered conformation as compared with that seen in previously determined anterior HOX / PBC structures . ^^^ |
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| Interacting proteins: P31269 and P40424 |
Pubmed |
SVM Score :0.0 |
| Pbx 1 , another Meis 1 cofactor , also induces apoptosis ; however , coexpressing HoxA 9 is incapable of rescuing Pbx mediated apoptosis . ^^^ |
|
| Interacting proteins: P31269 and P40424 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P31269 and P40424 |
Pubmed |
SVM Score :0.0 |
| NA |
|