| Interacting proteins: P30988 and O60896 |
Pubmed |
SVM Score :0.51053941 |
| We show that coexpression of RAMP 3 with human calcitonin receptor changed the relative potency of hCTR to human calcitonin ( hCAL ) and rat amylin . 0.51053941^^^ |
|
| Interacting proteins: P30988 and O60896 |
Pubmed |
SVM Score :0.0 |
| Thus , RAMP 1 or RAMP 3 can modify the calcitonin receptor ( CTR ) to also function as a high affinity amylin receptor like phenotype . ^^^ |
|
| Interacting proteins: P30988 and O60896 |
Pubmed |
SVM Score :0.0 |
| Furthermore , RAMP proteins have also been shown to govern the pharmacology of the calcitonin receptor , which in association with RAMP 1 or RAMP 3 , binds amylin with high affinity . ^^^ |
|
| Interacting proteins: P30988 and O60896 |
Pubmed |
SVM Score :0.0 |
| Utilizing RT PCR we found that NRK 49F cells express calcitonin receptor like receptor ( CRLR ) and receptor activity modifying protein 2 ( RAMP 2 ) but not RAMP 3 . ^^^ |
|
| Interacting proteins: P30988 and O60896 |
Pubmed |
SVM Score :0.0 |
| CGRP receptors are observed in presence of the RAMP1 / calcitonin receptor like receptor ( CRLR ) , but the association of RAMP 2 or RAMP 3 with CRLR generates an adrenomedullin receptor . ^^^ |
|
| Interacting proteins: P30988 and O60896 |
Pubmed |
SVM Score :0.0 |
| It is suggested that these may largely be explained by a combination of methodological factors and CGRP responsive receptors generated by CL and RAMP 2 or RAMP 3 and complexes of RAMPs with the calcitonin receptor . . ^^^ |
|
| Interacting proteins: P30988 and O60896 |
Pubmed |
SVM Score :0.0 |
| METHODS : We cultured rat neonatal cardiac fibroblasts with or without IL 1beta and measured ( 1 ) two molecular forms of adrenomedullin in culture medium by specific immunoradiometric assay ; ( 2 ) gene expression of adrenomedullin , calcitonin receptor like receptor ( CRLR ) , receptor activity modifying protein 2 ( RAMP 2 ) , and RAMP 3 , components of the adrenomedullin receptor , by Northern blot analysis or RT PCR analysis ; ( 3 ) intracellular cAMP levels in response to exogenously administered adrenomedullin ; and ( 4 ) ( 3 ) H proline incorporation with and without a specific adrenomedullin antisense oligodeoxynucleotide . ^^^ |
|
| Interacting proteins: P30988 and O60896 |
Pubmed |
SVM Score :0.0 |
| Co localization of adrenomedullin ( AM ) and its receptor components such as calcitonin receptor like receptor ( CRLR ) , receptor activity modifying protein ( RAMP ) 2 and RAMP 3 in peripheral tissues , including the heart , kidney , and vasculature , suggests an important role for the peptide as a regulator of cardiovascular function . ^^^ |
|
| Interacting proteins: P30988 and O60896 |
Pubmed |
SVM Score :0.0 |
| RAMP 3 is a coactivator that directs calcitonin receptor ( CTR ) and CTR like receptor ( CRLR ) glycosylation , trafficking , and ligand binding specificity . ^^^ |
|
| Interacting proteins: P30988 and O60896 |
Pubmed |
SVM Score :0.0 |
| When complexed with RAMP 3 , CTR interacts with amylin alone . ^^^ Thus amylin and CGRP interact specifically with heterodimeric complexes between CTR and RAMP 1 or RAMP 3 , and CGRP and AM interact with complexes between CRLR and RAMP 1 , RAMP 2 or RAMP3 . . ^^^ |
|
| Interacting proteins: P30988 and O60896 |
Pubmed |
SVM Score :0.0 |
| In the presence of RAMP 3 , the CTR only interacts with amylin . ^^^ |
|
| Interacting proteins: P30988 and O60896 |
Pubmed |
SVM Score :0.0 |
| The specificity of CRLR was clearly determined by the expression of RAMPs ; RAMP 1 converted CRLR to CGRP receptor , while RAMP 2 and RAMP 3 converted it to AM receptor , but the affinity of CTR for AMY was not increased by the expression of any known RAMPs . ^^^ |
|
| Interacting proteins: P30988 and O60896 |
Pubmed |
SVM Score :0.0 |
| Osteoclast like cells expressed CT receptor ( CTR ) , CT receptor like receptor ( CRLR ) and RAMP 2 , but did not express RAMP 1 or RAMP 3 . ^^^ |
|
| Interacting proteins: P30988 and O60896 |
Pubmed |
SVM Score :0.0 |
| CTR has been reported to act as an amylin receptor when heterodimerized with receptor activity modifying protein 1 ( RAMP 1 ) or RAMP 3 . mRNA expression of RAMP 1 and RAMP 3 in mammary tissue decreased during pregnancy and lactation , and amylin mRNA was undetectable , suggesting that up regulated CTR in lactating mammary tissues binds CT rather than amylin . ^^^ |
|
| Interacting proteins: P30988 and O60896 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and O60896 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and O60896 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and O60896 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and O60896 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and O60896 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and O60896 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and O60896 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and O60896 |
Pubmed |
SVM Score :0.0 |
| NA |
|