| Interacting proteins: P29474 and Q02156 |
Pubmed |
SVM Score :0.0 |
| Functional proteomic analysis of a three tier PKCepsilon Akt eNOS signaling module in cardiac protection . ^^^ Among 93 different PKCepsilon associated proteins that have been identified , Akt and endothelial nitric oxide ( NO ) synthase ( eNOS ) are of importance because of their independent abilities to promote cell survival and prevent cell death . ^^^ The simultaneous association of PKCepsilon , Akt , and eNOS has not been examined , and , in particular , the formation of a module containing these three proteins and the role of such a module in the regulation of NO production and cardiac protection are unknown . ^^^ Using recombinant proteins in vitro and PKCepsilon transgenic mouse hearts , we demonstrate the following : 1 ) PKCepsilon , Akt , and eNOS interact and form signaling modules in vitro and in the mouse heart . ^^^ Activation of either PKCepsilon or Akt enhances the formation of PKCepsilon Akt eNOS signaling modules . 2 ) PKCepsilon directly phosphorylates and enhances activation of Akt in vitro , and PKCepsilon activation increases phosphorylation and activation of Akt in PKCepsilon transgenic mouse hearts . 3 ) PKCepsilon directly phosphorylates eNOS in vitro , and this phosphorylation enhances eNOS activity . ^^^ |
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| Interacting proteins: P29474 and Q02156 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P29474 and Q02156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29474 and Q02156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29474 and Q02156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29474 and Q02156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29474 and Q02156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29474 and Q02156 |
Pubmed |
SVM Score :0.0 |
| NA |
|