| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| ET 1 caused a 2 . 5 fold increase in eNOS protein in BPAECs , inhibitable with an endothelin B receptor antagonist , and an increase in eNOS mRNA and nitrite production . ^^^ |
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| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| Cryostat sections of arterial and venous vessels from various size branches of the uterine artery and utero ovarian vein of the pig mesometrium in different phases of the estrous cycle were stained immunohistochemically for endothelial nitric oxide synthase ( eNOS ) , endothelin 1 ( ET 1 ) and endothelin B receptor ( ETB R ) using ABC method . ^^^ |
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| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND / AIMS : In experimental hepatopulmonary syndrome ( HPS ) , hepatic endothelin 1 ( ET 1 ) release during common bile duct ligation ( CBDL ) and ET 1 infusion in pre hepatic portal hypertension after portal vein ligation ( PVL ) initiate vasodilatation through an endothelin B receptor mediated increase in pulmonary endothelial nitric oxide synthase ( eNOS ) . ^^^ |
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| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| Plasma endothelin 1 and cGMP levels and lung NOS activity , cGMP , eNOS , preproendothelin 1 , endothelin converting enzyme 1 , endothelin A , and endothelin B receptor protein levels were similar in both groups . ^^^ |
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| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| Our data show 1 ) CBDL CH rats had a persistent blunted hypoxic pulmonary vasoconstriction similar to CBDL Den ; 2 ) the development of hypoxic pulmonary hypertension was completely prevented in the CBDL CH rats , as indicated by normal pulmonary arterial pressure and lack of right ventricular hypertrophy and pulmonary arteriole remodeling ; and 3 ) selective increases in expression of ET 1 , pulmonary endothelin B receptor , eNOS , and heme oxygenase 1 are potential mechanisms of protection against hypoxic pulmonary hypertension in the CBDL CH rats . ^^^ |
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| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| Additionally , chronic alcohol consumption down regulated endothelin B receptor , eNOS protein levels , and eNOS phosphorylation . ^^^ |
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| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| Plasma and liver samples were obtained 6 h after reperfusion for serum aminotransferase assays and RT PCR analysis of the mRNA for the genes of interest : endothelin 1 ( ET 1 ) , its receptors ET A and ET B , endothelial nitric oxide synthase ( eNOS ) , inducible nitric oxide synthase ( iNOS ) , heme oxygenase 1 ( HO 1 ) , cyclooxygenase 2 ( COX 2 ) , and tumor necrosis factor alpha ( TNF alpha ) . ^^^ |
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| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| Protein tyrosine kinase dependent and calcium calmodulin dependent pathways were involved in ET 1 induced activation of the constitutive NOS in CHO ETB / NOS cells , but coupling of the receptor to the enzyme in HUVEC appeared to be predominantly protein tyrosine kinase dependent . ^^^ |
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| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| Expression of messenger RNAs ( mRNAs ) encoding ET 1 , ET receptors ( ETA and ETB ) , ET converting enzyme , and the three nitric oxide synthase ( NOS ) isoforms ( NOS 1 , NOS 2 , and NOS 3 ) was readily detected in the rat thyroid . ^^^ After goiter formation was induced by thiouracil and a low iodine diet , there was increased expression of the genes encoding ET related proteins ( ET 1 , 3 . 2 fold ; ETA , 2 . 9 fold ; ETB , 3 . 5 fold ) as well as two of the three NOS isoforms ( NOS 1 , 2 . 7 fold ; NOS 3 , 4 . 9 fold ) . ^^^ |
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| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| In line with these findings , expression of ET 1 , ETA and ETB receptors , and endothelial NOS ( eNOS ) , assessed by RT PCR , and eNOS immunoreactivity , assessed by Western blotting , was significantly higher in the medulla than in the cortex . ^^^ |
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| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| This was associated with an increase in ET A and ET B receptor mRNA and a decrease in cardiac ecNOS protein . ^^^ Although quinapril did not restore the effects of ET B receptor stimulation or prevent the increase in ET B mRNA , it did restore cardiac ecNOS protein expression . ^^^ Thus , the inotropic response to ET 1 is biphasic due to an overall positive inotropic effect of ET A receptor stimulation and an ET B receptor mediated decrease in contractility at low ET 1 concentrations which appears to be mediated by cardiac ecNOS ( NO ) . ^^^ |
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| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| The aim of this study was to investigate the expression of ET 1 , ET A receptor , ET B receptor , and eNOS quantitatively in POPV rats . ^^^ One month after a left thoracotomy with either left main pulmonary artery ligation ( ligated group ) or no ligation ( control group ) , rat pulmonary arteries and lungs were used for Western blot analysis using specific antibodies against ET 1 , ET A receptor , ET B receptor , and eNOS . ^^^ The expression of ET 1 , ET B receptor , and eNOS was not different between ligated and control rats . ^^^ |
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| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we examined the role of endothelin ( ET ) 1 in this regulatory process , since ET 1 is able to induce eNOS via activation of the ET B receptor . ^^^ We conclude that eNOS expression in chronic hypoxic rat lungs is modified predominantly by hemodynamic factors , whereas the ET B receptor mediated pathway and hypoxia seem to be less important . . ^^^ |
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| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| This study assessed the temporal expression of endothelial NO synthase ( eNOS ) , preproET 1 , and ETA and ETB receptor mRNAs in the rat carotid artery after balloon injury using quantitative competitive reverse transcription polymerase chain reaction ( qcRT PCR ) and the ribonuclease protection assay ( RPA ) . ^^^ |
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| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| In genetically engineered Chinese hamster ovary cells expressing either ETB receptor or endothelial NOS or both , application of ET results in accelerated cell migration only when the receptor and the enzyme are coexpressed . ^^^ |
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| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| In the present study we have used in vitro activity assays of purified eNOS and in vitro binding assays with glutathione S transferase fusion proteins to show that the capacity to bind and inhibit eNOS is a common feature of membrane proximal regions of intracellular domain 4 of the BK B 2 , the Ang 2 AT 1 and the ET 1 ETB receptors , but not of the ATP P2Y2 receptor . ^^^ |
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| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| Here , using a model in which we have utilized isolated primary endothelial cells , we demonstrate that ET 1 binding to sinusoidal endothelial cell ETB receptors led to increased protein kinase B / Akt phosphorylation , endothelial cell nitric oxide synthase ( eNOS ) phosphorylation , and NO synthesis . ^^^ |
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| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| Liver samples were obtained 5 hrs after reperfusion for RT PCR analysis of the mRNA for genes of interest : endothelin 1 ( ET 1 ) , its receptors ETA and ETB , endothelial nitric oxide synthase ( eNOS ) , inducible nitric oxide synthase ( iNOS ) and heme oxygenase 1 ( HO 1 ) . ^^^ |
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| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| Functional link between ETB receptors and eNOS maintain tissue oxygenation in the normal liver . ^^^ |
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| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| Retinas were removed and either fixed in formalin for confocal microscope evaluation of retinal vascular filling or transferred to RNALater for quantitative reverse transcriptase polymerase chain reaction to evaluate expression of NOS 3 , NOS 1 , ET 1 , ETRA , ETRB , and the angiogenic factor adrenomedullin . ^^^ |
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| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24530 and P29474 |
Pubmed |
SVM Score :0.0 |
| NA |
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