| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| The human interleukin 3 receptor ( IL 3R ) is composed of an IL 3 specific alpha subunit ( IL 3R alpha ) and a common beta subunit ( beta c ) that is shared by IL 3 , granulocyte / macrophage colony stimulating factor ( GM CSF ) and IL 5 receptors . ^^^ |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| Gene for the alpha subunit of the human interleukin 3 receptor ( IL3RA ) localized to the 10 Y pseudoautosomal region . ^^^ |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| Two partial cDNAs encoding the human interleukin 3 receptor alpha subunit ( IL 3R alpha ) were cloned from KG 1 leukemic cells using the polymerase chain reaction . ^^^ |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| The alpha subunit of the human interleukin 3 receptor ( IL 3R alpha ) is a 70 kD glycoprotein member of the hematopoietin receptor superfamily . ^^^ |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| The human interleukin 3 receptor ( IL 3R ) is a heterodimer that comprises an IL 3 specific alpha chain ( IL 3R alpha ) and a common beta chain ( beta C ) that is shared with the receptors for granulocyte macrophage colony stimulating factor ( GM CSF ) and IL 5 . ^^^ |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| Cytokine R detectable on Ba but not MC , were interleukin 3 ( IL 3 ) R alpha ( CD 123 ) , IL 1RII ( CD121b ) , IL 2R alpha ( CD 25 ) and CD 40 . ^^^ |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| These cells can be classified as basophils or mast cells using monoclonal antibodies ( mAbs ) against leukocyte antigens , including mast cell tryptase , c kit ( = mast cell growth factor [ MGF ] receptor ) , interleukin 3 receptor alpha chain ( IL 3R alpha = CD 123 ) , and CD11b ( C3biR ) . ^^^ |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| Using a somatic cell hybrid mapping panel , we have assigned the mouse homolog of the human pseudoautosomal interleukin 3 receptor alpha subunit ( IL3RA ) gene to mouse Chromosome ( Chr ) 14 . ^^^ |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| Colony stimulating factor 2 receptor alpha ( CSF2RA ) and interleukin 3 receptor alpha ( IL3RA ) , two genes from the chromosome Xp and Yp pseudoautosomal region ( PAR ) , have been suggested as candidate genes for short stature in Turner syndrome . ^^^ |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| Roles of the N and C terminal domains of the interleukin 3 receptor alpha chain in receptor function . ^^^ |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| Receptors for KL ( CD 117 ) and interleukin 3 ( CD 123 ) , for which the ligands are active on a broad range of fetal liver progenitors , were detected on cells expressing both high and low levels of CD 34 . ^^^ |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| Here , we demonstrate that a large subset of DC in the T cell dependent areas of human lymphoid organs are nonactivated cells and belong to a separate lineage that can be identified by high levels of the interleukin 3 receptor alpha chain ( IL 3Ralphahi ) . ^^^ |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| Regulation of interleukin 3 receptor alpha chain ( IL 3R alpha ) on human monocytes by interleukin ( IL ) 4 , IL 10 , IL 13 , and transforming growth factor beta ( TGF beta ) . ^^^ |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| Cells from all samples strongly expressed c kit , granulocyte colony stimulating factor receptor ( G CSFR ) , c fms ( macrophage colony stimulating factor receptor ) , interleukin 3 receptor alpha chain ( IL 3Ralpha ) , and granulocyte macrophage colony stimulating factor receptor alpha chain ( GM CSFRalpha ) , and these data corresponded well to the growth responsiveness to the cytokines . ^^^ |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| Single CD34+ cells from the CD 123 subsets were cultured in a cytokine cocktail of stem cell factor , interleukin 3 ( IL 3 ) , IL 6 , GM CSF , erythropoietin , insulin like growth factor 1 , and basic fibroblast growth factor . ^^^ |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| The DTLIL 3 construct was more cytotoxic to interleukin 3 receptor ( IL3R ) bearing human myeloid leukemia cell lines than receptor negative cell lines based on assays of cytotoxicity using thymidine incorporation , growth in semi solid medium and induction of apoptosis . ^^^ |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| This was achieved based on simultaneous expression analysis of the monocyte markers CD 14 and CD 16 with antigens such as CD 33 , HLA DR , the integrin CD11c , and the interleukin 3 receptor alpha chain ( CD 123 ) which in absence of lineage related antigens have been used for description of dendritic cell precursors . ^^^ |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| The interleukin 3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells . ^^^ Flow cytometric studies using primary AML tissue showed that the interleukin 3 receptor alpha chain ( IL 3Ralpha or CD 123 ) was strongly expressed in CD34+ / CD38 cells ( 98 + / 2 % positive ) from 16 of 18 primary specimens . ^^^ |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| According to their morphology , functions , and surface staining they could be separated into two distinct subpopulations : mature HLA DRhi , mostly interleukin 3 R ( CD 123 ) negative cells , associated with thymocytes , some apoptotic , and expressed myeloid and activation markers but no lymphoid markers . ^^^ |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| CD 123 ( interleukin 3 receptor alpha chain ) . ^^^ CD 123 ( interleukin 3 receptor alpha chain ) . ^^^ |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| Interleukin 3 receptor alpha chain ( CD 123 ) is widely expressed in hematologic malignancies . ^^^ DESIGN AND METHODS : We analyzed the expression of the interleukin 3 ( IL 3 ) receptor a chain ( CD 123 ) in 22 normal samples and in a wide panel of hematologic malignancies using flow cytometry . ^^^ |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| Like `` normal ' ' basophils , basophils in MDS expressed interleukin 3 receptor alpha ( CD 123 ) , E NPP 3 ( CD203c ) , CR 1 ( CD 35 ) , CR 3 ( CD11b ) , CR 4 ( CD11c ) , membrane co factor protein ( CD 46 ) , decay accelerating factor ( CD 55 ) and membrane attack complex inhibitory factor ( CD 59 ) , as well as receptors for C3a , C5a ( CD 88 ) , and IgE . ^^^ |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To investigate the iufluence of dexamethasone ( DM ) on expression of interleukin 5 receptor alpha ( IL 5R alpha ) , interleukin 3 receptor alpha ( IL 3R alpha ) , granulocyte macrophage colony stimulating factor receptor alpha ( GM CSFR alpha ) and common beta receptor ( beta cR ) in bronchalveolar lavage fluid ( BALF ) eosinophils in guinea pig asthma model , and to study the mechanism of promotion effect of steroid on eosinophil apoptosis . ^^^ |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| It was observed that interferon beta ( IFN beta ) prevents the down regulation of the interleukin 3 receptor alpha chain ( IL 3Ralpha ) , which spontaneously occurs during culture of human monocytes . ^^^ |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| The interleukin 3 ( IL 3 ) receptor CD 123 was used to identify basophils in the leukocyte mixture . ^^^ |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| Promyelocytic leukemia zinc finger ( PLZF ) protein is a sequence specific DNA binding protein that represses the transcriptional activity of target genes such as those for cyclin A and the interleukin 3 receptor alpha chain . ^^^ |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| Besides immunophenotypic characteristics such as the absence of T cell markers and almost complete absence of markers of the myeloid lineage , these tumors express CD 4 , CD 56 and CD 123 , the receptor for interleukin 3 . ^^^ |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| Immunophenotypic features of acute myeloid leukemias overexpressing the interleukin 3 receptor alpha chain . ^^^ In a previous study we have shown that the interleukin 3 receptor alpha chain ( IL 3Ralpha ) is over expressed in about 45 % of acute myeloid leukemias ( AMLs ) and this phenomenon was associated with high blast cell counts at diagnosis , high rate of cycling of leukemic blasts and with a worse prognosis . ^^^ |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| In this study , we revealed that blood CD 123 ( hi ) DC in the presence of cytokine ( granulocyte macrophage colony stimulating factor and interleukin 3 ) undergo progressive , step wise maturation through an `` early ' ' stage , delineated by expression of the antigen detected by the new monoclonal antibody CMRF 58 ( CD 123 ( hi ) CMRF 58 ( + ) CD 40 ( ) CD 86 ( ) CD 83 ( ) ) to the `` late ' ' stage with costimulatory antigen expression ( CD 123 ( hi ) CMRF 58 ( + ) CD 40 ( + ) CD 86 ( + ) CD 83 ( + / ) ) . ^^^ |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| Leukemic blasts from patients with acute myeloid leukemia ( AML ) frequently express high levels of the interleukin 3 receptor alpha chain ( IL 3Ralpha ) . ^^^ |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| The complete DNA sequence of the break point was determined , revealing a partial duplication of the pseudoautosomal region 1 ( PAR 1 ) in the derivative 10 chromosome and causing a partial trisomy of the 12 known genes located between the interleukin 3 receptor alpha ( IL3RA ; position 1 . 1 Mb on the 10 and Y chromosomes ) and CD 99 ( position 2 . 2 Mb ) genes inclusively . ^^^ |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08700 and P26951 |
Pubmed |
SVM Score :0.0 |
| NA |
|