| Interacting proteins: P26717 and Q13241 |
Pubmed |
SVM Score :0.0 |
| To examine a possible association between variations in CD 94 and NKG 2 genes and genetic susceptibility to rheumatoid arthritis ( RA ) and systemic lupus erythematosus ( SLE ) , we carried out a systematic polymorphism screening of NKG 2 A ( KLRC 1 ) , NKG 2 C ( KLRC 2 ) and CD 94 ( KLRD 1 ) genes on a population basis . ^^^ |
|
| Interacting proteins: P26717 and Q13241 |
Pubmed |
SVM Score :0.0 |
| We now demonstrate that CD 94 glycoproteins form disulfide bonded heterodimers with the NKG2A / B , NKG2C , and NKG2E glycoproteins . ^^^ |
|
| Interacting proteins: P26717 and Q13241 |
Pubmed |
SVM Score :0.0 |
| In addition , using a yeast artificial chromosome contig spanning this region we determined that the human CD 94 , NKG2A , NKG2C , NKG2E , and NKR P1A ( NKR ) genes map to the short arm of chromosome 12 . ^^^ |
|
| Interacting proteins: P26717 and Q13241 |
Pubmed |
SVM Score :0.0 |
| Soluble NKG2C , D and CD 94 lectin domains bind solubilized affinity purified HLA class 1 antigens on their own , whereas NKG2A and B require association with CD 94 lectin domains for binding . ^^^ |
|
| Interacting proteins: P26717 and Q13241 |
Pubmed |
SVM Score :0.0 |
| Freshly isolated leukaemic NK cells transcribed mRNA for CD 94 associated molecule NKG2C at an abnormally high level , and upon stimulation with IL 2 and / or IL 12 they expressed NKG2A as well . ^^^ |
|
| Interacting proteins: P26717 and Q13241 |
Pubmed |
SVM Score :0.0 |
| Unlike normal T cells , in which CD 94 is assembled with glycoproteins of the NKG 2 family to form functional receptors with activating or inhibitory properties , most CD94+ MM T cells were devoid of both the NKG 2 A and NKG 2 C glycoproteins detected in the inhibitory or activating form respectively . ^^^ |
|
| Interacting proteins: P26717 and Q13241 |
Pubmed |
SVM Score :0.0 |
| CD 94 , NKG2A , NKG2C and Ly49B were expressed first followed by Ly49G , then Ly49C and 1 and finally , Ly49A , D , E and F . ^^^ |
|
| Interacting proteins: P26717 and Q13241 |
Pubmed |
SVM Score :0.0 |
| Whereas single chimpanzee orthologs for CD 94 , NKG2A , NKG2E , and NKG2F were identified , two chimpanzee paralogs of the human NKG2C gene were defined . ^^^ |
|
| Interacting proteins: P26717 and Q13241 |
Pubmed |
SVM Score :0.0 |
| Different NKG 2 members could be associated with CD 94 , either inhibitory ( NKG2A / B ) or activating ( NKG2C ) . ^^^ |
|
| Interacting proteins: P26717 and Q13241 |
Pubmed |
SVM Score :0.0 |
| Monoclonal T cell expansions in asymptomatic individuals and in patients with large granular leukemia consist of cytotoxic effector T cells expressing the activating CD 94 : NKG2C / E and NKD2D killer cell receptors . ^^^ However , in the other 2 individuals ( ages 28 36 years ) , large stable ( > 3 years ) monoclonal expansions of CD 3 ( + ) CD 8 ( + ) CD45RA ( + ) CD 27 ( ) CD 57 ( + ) CD 94 ( + ) NKG2C ( + ) were found which rendered these controls phenotypically indistinguishable from TLGL leukemia patients . ^^^ |
|
| Interacting proteins: P26717 and Q13241 |
Pubmed |
SVM Score :0.0 |
| The activating form of CD 94 receptor complex : CD 94 covalently associates with the Kp 39 protein that represents the product of the NKG 2 C gene . ^^^ The CD 94 associated Kp 39 molecule can be detected only in NKG 2 A P25+ cells , i . e . cells expressing NKG 2 C molecules . ^^^ Finally , biochemical analysis of COS 7 cells cotransfected with CD 94 and NKG 2 C demonstrates the identity between Kp 39 and NKG 2 C molecules . ^^^ Altogether , our data demonstrate that NKG 2 C molecules associate with CD 94 to form an activating receptor complex in a subset of human NK cells . . ^^^ |
|
| Interacting proteins: P26717 and Q13241 |
Pubmed |
SVM Score :0.0 |
| CD94 / NKG2C , an activating NK cell receptor of the C type lectin superfamily that binds to HLA E , noncovalently associates with DAP 12 , a membrane receptor containing an immunoreceptor tyrosine based activating motif . ^^^ |
|
| Interacting proteins: P26717 and Q13241 |
Pubmed |
SVM Score :0.0 |
| The gene order established is D12S77 CD 94 NKG2D NKG2F NKG2E NKG2C NKG2A . ^^^ |
|
| Interacting proteins: P26717 and Q13241 |
Pubmed |
SVM Score :0.0 |
| Developing NK cells express first CD 94 , then NKG2A , NKG2E , and finally NKG2C . ^^^ |
|
| Interacting proteins: P26717 and Q13241 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that , in the absence of DAP 12 , rhesus monkey NKG2A is preferentially expressed at the cell surface with CD 94 due to a single amino acid difference in the transmembrane of NKG2A and NKG2C . ^^^ Furthermore , in the context of an NKG2A transmembrane , the stalk domain of NKG2C was found to enhance heterodimer formation with CD 94 compared with the stalk domain of NKG2A . ^^^ In the presence of DAP 12 , the ability of NKG2C to compete for cell surface CD 94 heterodimerization is enhanced and approaches that of NKG2A . ^^^ |
|
| Interacting proteins: P26717 and Q13241 |
Pubmed |
SVM Score :0.0 |
| Several of the differentially expressed genes can possibly contribute to the enhanced cytotoxic activity of hepatic NK cells : cell membrane receptors like NKG2D , NKG2C , CD 94 , ecto ATPase ; signaling molecules like phosphatidylinositol 3 kinase ; granule associated effector molecules like granzymes and defensin NP 3 . ^^^ |
|
| Interacting proteins: P26717 and Q13241 |
Pubmed |
SVM Score :0.0 |
| Activating CD 94 : NKG2C and inhibitory CD 94 : NKG2A receptors are expressed by distinct subsets of committed CD8+ TCR alphabeta lymphocytes . ^^^ A subset of CD 8 ( + ) T cells express the natural killer cell receptors CD 94 : NKG2A or CD 94 : NKG2C . ^^^ We found that although many CD 8 ( + ) T cells transcribe CD 94 and NKG2C , expression of a functional CD 94 : NKG2C receptor is restricted to highly differentiated effector cells . ^^^ |
|
| Interacting proteins: P26717 and Q13241 |
Pubmed |
SVM Score :0.0 |
| We found a constitutive expression of NKG 2 E in CD 94 depleted resting peripheral CD4+ cells , whereas inductions of NKG 2 A and NKG 2 C required chronic cell activation and occurred after expression of CD 94 . ^^^ We found that CD 3 mediated stimulation induces the expression of CD 94 first by day 5 of culture , followed by NKG 2 A by day 15 and finally NKG 2 C , which is not detected until 20 days after repeated stimulation . ^^^ |
|
| Interacting proteins: P26717 and Q13241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26717 and Q13241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26717 and Q13241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26717 and Q13241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26717 and Q13241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26717 and Q13241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26717 and Q13241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26717 and Q13241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13241 and P26717 |
Pubmed |
SVM Score :0.0 |
| CD94 / NKG2C , an activating NK cell receptor of the C type lectin superfamily that binds to HLA E , noncovalently associates with DAP 12 , a membrane receptor containing an immunoreceptor tyrosine based activating motif . ^^^ |
|
| Interacting proteins: Q13241 and P26717 |
Pubmed |
SVM Score :0.0 |
| We now demonstrate that CD 94 glycoproteins form disulfide bonded heterodimers with the NKG2A / B , NKG2C , and NKG2E glycoproteins . ^^^ |
|
| Interacting proteins: Q13241 and P26717 |
Pubmed |
SVM Score :0.0 |
| In addition , using a yeast artificial chromosome contig spanning this region we determined that the human CD 94 , NKG2A , NKG2C , NKG2E , and NKR P1A ( NKR ) genes map to the short arm of chromosome 12 . ^^^ |
|
| Interacting proteins: Q13241 and P26717 |
Pubmed |
SVM Score :0.0 |
| The activating form of CD 94 receptor complex : CD 94 covalently associates with the Kp 39 protein that represents the product of the NKG 2 C gene . ^^^ The CD 94 associated Kp 39 molecule can be detected only in NKG 2 A P25+ cells , i . e . cells expressing NKG 2 C molecules . ^^^ Finally , biochemical analysis of COS 7 cells cotransfected with CD 94 and NKG 2 C demonstrates the identity between Kp 39 and NKG 2 C molecules . ^^^ Altogether , our data demonstrate that NKG 2 C molecules associate with CD 94 to form an activating receptor complex in a subset of human NK cells . . ^^^ |
|
| Interacting proteins: Q13241 and P26717 |
Pubmed |
SVM Score :0.0 |
| The gene order established is D12S77 CD 94 NKG2D NKG2F NKG2E NKG2C NKG2A . ^^^ |
|
| Interacting proteins: Q13241 and P26717 |
Pubmed |
SVM Score :0.0 |
| Soluble NKG2C , D and CD 94 lectin domains bind solubilized affinity purified HLA class 1 antigens on their own , whereas NKG2A and B require association with CD 94 lectin domains for binding . ^^^ |
|
| Interacting proteins: Q13241 and P26717 |
Pubmed |
SVM Score :0.0 |
| Freshly isolated leukaemic NK cells transcribed mRNA for CD 94 associated molecule NKG2C at an abnormally high level , and upon stimulation with IL 2 and / or IL 12 they expressed NKG2A as well . ^^^ |
|
| Interacting proteins: Q13241 and P26717 |
Pubmed |
SVM Score :0.0 |
| Unlike normal T cells , in which CD 94 is assembled with glycoproteins of the NKG 2 family to form functional receptors with activating or inhibitory properties , most CD94+ MM T cells were devoid of both the NKG 2 A and NKG 2 C glycoproteins detected in the inhibitory or activating form respectively . ^^^ |
|
| Interacting proteins: Q13241 and P26717 |
Pubmed |
SVM Score :0.0 |
| CD 94 , NKG2A , NKG2C and Ly49B were expressed first followed by Ly49G , then Ly49C and 1 and finally , Ly49A , D , E and F . ^^^ |
|
| Interacting proteins: Q13241 and P26717 |
Pubmed |
SVM Score :0.0 |
| Whereas single chimpanzee orthologs for CD 94 , NKG2A , NKG2E , and NKG2F were identified , two chimpanzee paralogs of the human NKG2C gene were defined . ^^^ |
|
| Interacting proteins: Q13241 and P26717 |
Pubmed |
SVM Score :0.0 |
| Different NKG 2 members could be associated with CD 94 , either inhibitory ( NKG2A / B ) or activating ( NKG2C ) . ^^^ |
|
| Interacting proteins: Q13241 and P26717 |
Pubmed |
SVM Score :0.0 |
| Monoclonal T cell expansions in asymptomatic individuals and in patients with large granular leukemia consist of cytotoxic effector T cells expressing the activating CD 94 : NKG2C / E and NKD2D killer cell receptors . ^^^ However , in the other 2 individuals ( ages 28 36 years ) , large stable ( > 3 years ) monoclonal expansions of CD 3 ( + ) CD 8 ( + ) CD45RA ( + ) CD 27 ( ) CD 57 ( + ) CD 94 ( + ) NKG2C ( + ) were found which rendered these controls phenotypically indistinguishable from TLGL leukemia patients . ^^^ |
|
| Interacting proteins: Q13241 and P26717 |
Pubmed |
SVM Score :0.0 |
| To examine a possible association between variations in CD 94 and NKG 2 genes and genetic susceptibility to rheumatoid arthritis ( RA ) and systemic lupus erythematosus ( SLE ) , we carried out a systematic polymorphism screening of NKG 2 A ( KLRC 1 ) , NKG 2 C ( KLRC 2 ) and CD 94 ( KLRD 1 ) genes on a population basis . ^^^ |
|
| Interacting proteins: Q13241 and P26717 |
Pubmed |
SVM Score :0.0 |
| Developing NK cells express first CD 94 , then NKG2A , NKG2E , and finally NKG2C . ^^^ |
|
| Interacting proteins: Q13241 and P26717 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that , in the absence of DAP 12 , rhesus monkey NKG2A is preferentially expressed at the cell surface with CD 94 due to a single amino acid difference in the transmembrane of NKG2A and NKG2C . ^^^ Furthermore , in the context of an NKG2A transmembrane , the stalk domain of NKG2C was found to enhance heterodimer formation with CD 94 compared with the stalk domain of NKG2A . ^^^ In the presence of DAP 12 , the ability of NKG2C to compete for cell surface CD 94 heterodimerization is enhanced and approaches that of NKG2A . ^^^ |
|
| Interacting proteins: Q13241 and P26717 |
Pubmed |
SVM Score :0.0 |
| Several of the differentially expressed genes can possibly contribute to the enhanced cytotoxic activity of hepatic NK cells : cell membrane receptors like NKG2D , NKG2C , CD 94 , ecto ATPase ; signaling molecules like phosphatidylinositol 3 kinase ; granule associated effector molecules like granzymes and defensin NP 3 . ^^^ |
|
| Interacting proteins: Q13241 and P26717 |
Pubmed |
SVM Score :0.0 |
| Activating CD 94 : NKG2C and inhibitory CD 94 : NKG2A receptors are expressed by distinct subsets of committed CD8+ TCR alphabeta lymphocytes . ^^^ A subset of CD 8 ( + ) T cells express the natural killer cell receptors CD 94 : NKG2A or CD 94 : NKG2C . ^^^ We found that although many CD 8 ( + ) T cells transcribe CD 94 and NKG2C , expression of a functional CD 94 : NKG2C receptor is restricted to highly differentiated effector cells . ^^^ |
|
| Interacting proteins: Q13241 and P26717 |
Pubmed |
SVM Score :0.0 |
| We found a constitutive expression of NKG 2 E in CD 94 depleted resting peripheral CD4+ cells , whereas inductions of NKG 2 A and NKG 2 C required chronic cell activation and occurred after expression of CD 94 . ^^^ We found that CD 3 mediated stimulation induces the expression of CD 94 first by day 5 of culture , followed by NKG 2 A by day 15 and finally NKG 2 C , which is not detected until 20 days after repeated stimulation . ^^^ |
|
| Interacting proteins: Q13241 and P26717 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13241 and P26717 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13241 and P26717 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13241 and P26717 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13241 and P26717 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13241 and P26717 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13241 and P26717 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13241 and P26717 |
Pubmed |
SVM Score :0.0 |
| NA |
|