| Interacting proteins: P22460 and P16389 |
Pubmed |
SVM Score :0.0 |
| Three of the regions , Hk 2 , Hk 3 , and Hk 4 , are produced by three tightly linked loci , located on the third chromosome 7 . 25 map units from the locus fuzzy . ^^^ |
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| Interacting proteins: P22460 and P16389 |
Pubmed |
SVM Score :0.0 |
| The ontogenesis of the glucose transporters GLUT 1 , GLUT 2 , and GLUT 4 and the hexokinases HK 1 , HK 2 , and HK 4 ( glucokinase ) was studied in rat tissues . ^^^ |
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| Interacting proteins: P22460 and P16389 |
Pubmed |
SVM Score :0.0 |
| The human kallikrein ( hk ) family , located on chromosome 19 , encodes prostate specific antigen ( PSA [ or hK 3 ] ) , hK 2 , hK 4 , and hK 15 ( prostin ) , as well as other serine proteases . ^^^ Data are emerging that show that active hK 2 , hK 4 , and hK 15 may be important to convert pro PSA to the active PSA enzyme . ^^^ |
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| Interacting proteins: P22460 and P16389 |
Pubmed |
SVM Score :0.0 |
| To examine the roles that hK 4 , as well as PSA and hK 2 , play in processes associated with progression , these kallikreins were separately transfected into the PC 3 prostate cancer cell line , and the consequence of their stable transfection was investigated . ^^^ PC 3 cells expressing hK 4 had a decreased growth rate , but no changes in cell proliferation were observed in the cells expressing PSA or hK 2 . hK 4 and PSA , but not hK 2 , induced a 2 . 4 fold and 1 . 7 fold respective increase , in cellular migration , but not invasion , through Matrigel , a synthetic extracellular matrix . ^^^ |
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| Interacting proteins: P22460 and P16389 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : We conclude that , in serum and urine of female to male transsexuals after testosterone administration , hK 3 ( prostate specific antigen ) and to a lesser extent hK 2 concentrations increase dramatically , but concentration of other kallikreins increase either moderately in serum ( hK 5 , hK 6 , hK 7 , hK 8 , hK 10 , and hK 11 ) or not at all in either serum ( hK 4 , hK 13 , hK 14 ) or urine ( hK 4 , hK 5 , hK 6 , hK 7 , hK 8 , hK 10 , hK 11 , hK 13 , hK 14 ) . . ^^^ |
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| Interacting proteins: P22460 and P16389 |
Pubmed |
SVM Score :0.0 |
| HKIII mRNA was present at low levels in the junctional zone and glucokinase ( HKIV ) mRNA was not detected , indicating that HKI and HKII are the two major placental HK isoenzymes . ^^^ |
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| Interacting proteins: P22460 and P16389 |
Pubmed |
SVM Score :0.0 |
| Experimental studies of the initiation and progression of liver tumours have demonstrated a shift in expression from that of HKIV to HKI and HKII , with increased HK binding to mitochondria and a > 100 fold increase in HK activity . ^^^ |
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| Interacting proteins: P22460 and P16389 |
Pubmed |
SVM Score :0.0 |
| In AH 130 cells cultured in dishes , HKI and HKII were expressed at a similar level , but HKIII and HKIV were not . ^^^ |
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| Interacting proteins: P22460 and P16389 |
Pubmed |
SVM Score :0.0 |
| Using interspecific backcrosses between Mus musculus and Mus spretus , we have chromosomally mapped in the mouse the Shaker related K ( + ) channel genes Kcna 1 , Kcna 2 , Kcna 4 , Kcna 5 , and Kcna 6 ; the Shab related gene Kcnb 1 ; the Shaw related gene Kcnc 4 ; and the Shal related gene Kcnd 2 . ^^^ The following localizations were determined : Chr 2 , cen Acra Kcna 4 Pax 6 a Pck 1 Kras 3 Kcn b 1 ( corresponding human Chrs 11p and 20q , respectively ) ; Chr 3 , cen Hao 2 ( Kcna 2 , Kcnc 4 ) Amy 1 ( human Chr 1 ) ; and Chr 6 , cen Cola 2 Met Kcnd 2 Cpa Tcrb adr / Clc 1 Hox 1 . 1 Myk 103 Raf 1 ( Tpi 1 , Kcna 1 , Kcna 5 , Kcna 6 ) ( human Chrs 7q and 12p , respectively ) . ^^^ |
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| Interacting proteins: P22460 and P16389 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22460 and P16389 |
Pubmed |
SVM Score :0.0 |
| NA |
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