| Interacting proteins: O75293 and Q9Y6R4 |
Pubmed |
SVM Score :0.0 |
| The GADD45beta protein binds and activates MTK 1 ( = MEKK 4 ) , which is a member of the MAPKKK family kinases and an upstream activator of the p 38 MAPK cascade . ^^^ Antisense inhibition of GADD45beta expression suppresses the TGF beta induced delayed p 38 activation , whereas overexpression of GADD45beta activates the p 38 MAPK via MTK 1 . ^^^ |
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| Interacting proteins: O75293 and Q9Y6R4 |
Pubmed |
SVM Score :0.0 |
| The forming acini expressed BRCA 1 , GADD45beta , MEKK 4 , and the JNK activating complex GADD 45beta MEKK 4 in a glucocorticoid dependent fashion . ^^^ |
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| Interacting proteins: O75293 and Q9Y6R4 |
Pubmed |
SVM Score :0.0 |
| Using a yeast two hybrid method , three related proteins , GADD45alpha ( = GADD 45 ) , GADD 45 , ( = MyD 118 ) , and GADD45gamma , were identified that bound to an N terminal domain of MTK 1 . ^^^ |
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| Interacting proteins: O75293 and Q9Y6R4 |
Pubmed |
SVM Score :0.0 |
| GADD45beta / GADD45gamma and MEKK 4 comprise a genetic pathway mediating STAT 4 independent IFNgamma production in T cells . ^^^ Expression of GADD45beta or GADD45gamma promotes IFNgamma production in MEKK4+ / + T cells , but not in MEKK 4 / cells or in cells treated with a p 38 inhibitor . ^^^ Thus , MEKK 4 mediates the action of GADD45beta and GADD45gamma on p 38 activation and IFNgamma production . ^^^ |
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| Interacting proteins: O75293 and Q9Y6R4 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75293 and Q9Y6R4 |
Pubmed |
SVM Score :0.0 |
| NA |
|