| Interacting proteins: O75293 and P12004 |
Pubmed |
SVM Score :0.0 |
| Cyp2b20 , growth arrest and damage inducible gene beta ( Gadd45beta ) , tumor necrosis factor alpha induced protein 2 and insulin like growth factor binding protein 1 ( Igfbp 5 ) genes and proteins were upregulated by oxazepam , and Cyp2b20 , Cyclin D 1 , proliferating cell nuclear antigen , Igfbp 5 , Gadd45beta and cell death inducing DNA fragmentation factor alpha subunit like effector A exhibited higher expression after Wy 14 , 643 treatment . ^^^ |
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| Interacting proteins: O75293 and P12004 |
Pubmed |
SVM Score :0.0 |
| This normal cell line DNA demethylase activity associates with PCNA immune complex that is inhibited by CDKI proteins p 21 ( waf 1 ) / Gadd45alpha and Gadd45beta . ^^^ This cancer cell line DNA demethylase activity is not associated with PCNA immune complex and is not inhibited by CDKI proteins p 21 ( waf 1 ) / Gadd45alpha and Gadd45beta . ^^^ |
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| Interacting proteins: O75293 and P12004 |
Pubmed |
SVM Score :0.0 |
| These results , together with the findings that Gadd45beta remained unchanged in cyclin E 1 RNAi cells , suggested that the induction of apoptosis by knock down of hLRH 1 was closely related to the down regulation of Gadd45beta . . ^^^ |
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| Interacting proteins: O75293 and P12004 |
Pubmed |
SVM Score :0.0 |
| Treatment of 1 LN cells with alpha2M * down regulated apoptosis and promoted NF kappaB activation as shown by increases of Bcl 2 , p Bad ( Ser 136 ) , p FOXO 1 ( Ser 253 ) , p GSK3beta ( Ser 9 ) , XIAP , NF kappaB , cyclin D 1 , GADD45beta , p ASK 1 ( Ser 83 ) , and TRAF 2 in a time of incubation dependent manner . alpha2M * treatment of 1 LN cells , however , showed no increase in the activation of caspase 3 , 9 , or 12 . ^^^ |
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| Interacting proteins: O75293 and P12004 |
Pubmed |
SVM Score :0.0 |
| It is also shown that MyD 118 is a nuclear protein , which regardless of the pathway induced , predominantly localized within the cell nucleus , and interacted with the DNA replication and repair protein PCNA and the cyclin dependent kinase inhibitor P21WAF1 / CIP1 . ^^^ The differentiation primary response gene MyD 118 , related to GADD 45 , encodes for a nuclear protein which interacts with PCNA and p21WAF1 / CIP1 . ^^^ |
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| Interacting proteins: O75293 and P12004 |
Pubmed |
SVM Score :0.0 |
| Association with the growth arrest and DNA damage inducible proteins gadd 45 and MyD 118 , further demonstrates the role of PCNA as a component of the cell cycle control apparatus . . ^^^ |
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| Interacting proteins: O75293 and P12004 |
Pubmed |
SVM Score :0.0 |
| Characterization of MyD 118 , Gadd 45 , and proliferating cell nuclear antigen ( PCNA ) interacting domains . ^^^ PCNA impedes MyD 118 AND Gadd 45 mediated negative growth control . ^^^ MyD 118 and Gadd 45 are related proteins that previously were shown to interact with proliferating cell nuclear antigen ( PCNA ) , implicated in DNA replication , DNA repair , and cell cycle progression . ^^^ To establish the role of MyD 118 and Gadd 45 interactions with PCNA , in this work we sought to identify the interacting domains and analyze the significance of this interaction in negative growth control . ^^^ Using complementary in vivo and in vitro interaction assays the N terminal ( 1 46 ) and middle ( 100 127 ) regions of PCNA were identified as harboring MyD 118 and Gadd 45 interacting domains , whereas PCNA interacting domains within MyD 118 and Gadd 45 were localized to the C termini of these proteins ( amino acids 114 156 and 137 165 , respectively ) . ^^^ |
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| Interacting proteins: O75293 and P12004 |
Pubmed |
SVM Score :0.0 |
| Recently , we have shown that both MyD 118 and GADD 45 interact with proliferating cell nuclear antigen ( PCNA ) , a protein that plays a central role in DNA replication , DNA repair , and cell cycle progression , as well as with the universal cyclin dependent kinase inhibitor p 21 . ^^^ Moreover , it is shown that CR 6 interacts with PCNA via a domain that also mediates interaction of both GADD 45 and MyD 118 with PCNA . ^^^ Importantly , evidence has been obtained that interaction of CR 6 with PCNA impedes the function of this protein in negative growth control , similar to observations reported for MyD 118 and GADD45 . . ^^^ |
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| Interacting proteins: O75293 and P12004 |
Pubmed |
SVM Score :0.0 |
| The PCNA gene is induced by p 53 , while PCNA protein interacts with p 53 controlled proteins Gadd 45 , MyD 118 , CR 6 and , most importantly , p 21 , in the process of deciding cell fate . ^^^ |
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| Interacting proteins: O75293 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75293 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75293 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75293 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75293 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
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