| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.60068726 |
| Vascular endothelial growth factor receptor 3 ( VEGFR 3 / Flt4 ) binds two known members of the VEGF ligand family , VEGF C and VEGF D , and has a critical function in the remodelling of the primary capillary vasculature of midgestation embryos . 0.60068726^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.67371106 |
| BACKGROUND : Vascular endothelial growth factor D ( VEGF D ) binds and activates vascular endothelial growth factor receptor 2 ( VEGFR 2 ) , which signals for angiogenesis , and VEGFR 3 , which signals for lymphangiogenesis . 0.67371106^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Vascular endothelial growth factor D ( VEGF D ) is a ligand for the tyrosine kinases VEGF receptor 2 ( Flk 1 ) and VEGF receptor 3 ( Flt 4 ) . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Vascular endothelial growth factor D ( VEGF D ) binds and activates the endothelial cell tyrosine kinase receptors VEGF receptor 2 ( VEGFR 2 ) and VEGF receptor 3 ( VEGFR 3 ) , is mitogenic for endothelial cells , and shares structural homology and receptor specificity with VEGF C . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Vascular endothelial growth factor D ( VEGF D ) , the most recently discovered mammalian member of the VEGF family , is an angiogenic protein that activates VEGF receptor 2 ( VEGFR 2 / Flk1 / KDR ) and VEGFR 3 ( Flt 4 ) . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| The angiogenic factor vascular endothelial growth factor D ( VEGF D ) isa ligand for VEGF receptor 3 ( VEGFR 3 / Flt 4 ) and receptor 2 ( VEGFR 2 / KDR ) and is implicated in the development of lymphatic vessels and promotion of lymphatic metastases . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Flt 4 positive vessel density correlates with vascular endothelial growth factor d expression , nodal status , and prognosis in breast cancer . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| In order to better understand the mechanisms controlling lymphatic growth and lymph node metastasis in human ductal pancreatic cancer , we analyzed the expression pattern of the vascular endothelial growth factor D ( VEGF D ) , its receptor VEGF receptor 3 ( VEGFR 3 ) and the lymphatic endothelium specific hyaluronan receptor LYVE 1 in a panel of 19 primary human ductal pancreatic tumors and 10 normal pancreas specimens . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Vascular endothelial growth factor D ( VEGF D ) stimulates growth of vascular and lymphatic endothelial cells by signaling through the tyrosine kinase receptors KDR ( VEGFR 2 ) and Flt 4 ( VEGFR 3 ) . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Vascular endothelial growth factor D and its receptor VEGFR 3 : two novel independent prognostic markers in gastric adenocarcinoma . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Vascular endothelial growth factor D activates VEGFR 3 expressed in osteoblasts inducing their differentiation . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Another tyrosine kinase receptor , VEGFR 3 ( flt 4 ) binds VEGF C and VEGF D and is more important in the development of lymphatic vessels . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| VEGF C and VEGF D expression in neuroendocrine cells and their receptor , VEGFR 3 , in fenestrated blood vessels in human tissues . ^^^ In this study , we have investigated the expression of VEGFR 3 and its ligands VEGF C and VEGF D in fetal and adult tissues . ^^^ VEGF C and VEGF D , which bind both VEGFR 2 and VEGFR 3 were expressed in vascular smooth muscle cells . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| VEGF C and VEGF D , as ligands for VEGFR 3 are also capable of stimulating lymphangiogenesis and at least VEGF C can enhance lymphatic metastasis . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| The VEGFR 2 and VEGFR 3 binding VEGF homologues , VEGF C and VEGF D , are mitogens for both vascular and lymphatic endothelial cells . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| The vascular endothelial growth factor receptor 3 ( VEGFR 3 / FLT4 ) is a receptor tyrosine kinase that regulates angiogenesis and vasculogenesis in response to the binding of the ligands VEGF C and VEGF D . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Introducing a mutation at the kinase domain of VEGFR 3 or treatment with blocking antibody against either VEGFR 3 or beta ( 1 ) integrin inhibited cell migration induced by ECM and VEGF D , indicating that signals from both beta ( 1 ) integrin and VEGFR 3 are required for this cell function . . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Proteolysis is essential to generate human VEGF D that binds the angiogenic receptor VEGF receptor 2 ( VEGFR 2 ) and the lymphangiogenic receptor VEGFR 3 with high affinity . ^^^ Both isoforms are proteolytically processed in a similar fashion to human VEGF D to generate a range of secreted derivatives and bind and cross link VEGFR 3 with similar potency . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| These are VEGF C , VEGF D , VEGFR 3 , LYVE 1 , podoplanin , and Prox 1 . ^^^ Monoclonal antibodies raised against VEGFR 3 and against its ligands , VEGF C and VEGF D , have offered an insight into expression studies in tissues . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Characterization of indolinones which preferentially inhibit VEGF C and VEGF D induced activation of VEGFR 3 rather than VEGFR 2 . ^^^ VEGF C and VEGF D are lymphangiogenic factors that bind to and activate VEGFR 3 , a fms like tyrosine kinase receptor whose expression is limited almost exclusively to lymphatic endothelium in the adult . ^^^ Furthermore , to understand the different roles of VEGF C , VEGF D , VEGFR 2 and VEGFR 3 in pathological situations it will be necessary to dissect the complex interactions of these ligands and their receptors . ^^^ We showed that Cys 152 > Ser mutants of processed rat VEGF C can activate VEGFR 3 but not VEGFR 2 , while the corresponding mutation in rat VEGF D inhibits its ability to activate both VEGFR 2 and VEGFR 3 . ^^^ We also synthesized and characterized indolinones that differentially block VEGF C and VEGF D induced VEGFR 3 kinase activity compared to that of VEGFR 2 . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Now that lymphatic specific vascular endothelial growth factors ( VEGF C and VEGF D ) and molecular cell surface markers such as the VEGFR 3 receptor have been identified , this definition needs to be updated . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To localize vascular endothelial growth factor C ( VEGF C ) and VEGF D in synovial specimens in relation to their VEGFR 2 and VEGFR 3 receptors in blood and lymphatic vessels . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| A comparison of mean nidus size and average age at operation revealed significant differences between patients positive for VEGF C , VEGF D , Flt 1 , or Flt 4 . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Vascular endothelial growth factor receptor 3 ( VEGFR 3 ) mediates lymphatic endothelial cell ( LEC ) growth , migration , and survival by binding VEGF C and VEGF D . ^^^ Vascular endothelial growth factor receptor 3 ( VEGFR 3 ) mediates lymphatic endothelial cell ( LEC ) growth , migration , and survival by binding VEGF C and VEGF D . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| In a skin model , Ad VEGF D Delta N Delta C induced angiogenesis and lymphangiogenesis , as indicated by staining with laminin , VEGFR 2 , and VEGFR 3 , whereas Ad VEGF A ( 165 ) stimulated the selective growth of blood vessels . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Recently , VEGFR 3 ligands , VEGF C , and VEGF D were reported to promote tumor lymphangiogenesis and lymphatic metastasis , and these processes were inhibited by blocking of the VEGFR 3 signaling pathway . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| The recent discovery of the key lymphangiogenic factors VEGF C and VEGF D and their receptor VEGFR 3 has allowed novel insights into how the lymphatic vessels and blood vessels coordinately grow and affect human disease . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Two of its family members , VEGF C and VEGF D , regulate the lymphatic endothelial cells via their receptor VEGFR 3 . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| We aimed to assess the relationship of the angiogenic cytokines VEGF A , VEGF C , and VEGF D and their receptors VEGFR 2 and VEGFR 3 in the adenoma carcinoma sequence and in metastatic spread of colorectal cancer ( CRC ) . mRNA expression levels were measured using semi quantitative reverse transcription polymerase chain reaction in 70 CRC ( 35 with paired mucosae ) and 20 adenomatous polyps . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| In conclusion , these results support a role for VEGFR 3 and its ligands VEGF C and / or VEGF D in cell to cell signalling in adult blood vessel angiogenesis . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Tumor vessels positive for VEGF D were also positive for its receptors , VEGF receptor 2 ( VEGFR 2 ) and / or VEGFR 3 but negative for VEGF D mRNA , indicating that VEGF D is secreted by tumor cells and subsequently associates with endothelium via receptor mediated uptake . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Firstly , ectopic expression of a soluble VEGFR 3 receptor globulin protein in MT 450 tumor cells that are highly metastatic via the lymphatics blocked VEGF C and VEGF D activity and suppressed metastasis formation in both the regional lymph nodes and the lungs . ^^^ These data show that expression of VEGF C and VEGF D in tissue culture does not reflect expression in vivo and that activation of VEGFR 3 in the absence of VEGFR 2 activation is sufficient to promote tumor induced lymphangiogenesis and metastasis , and they support the notion that blockade of VEGFR 3 activation will be useful as a novel form of cancer therapy . . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Their CM VEGF C and VEGF D increase in response to plasma cell CM and trigger plasma cell proliferation via VEGFR 3 . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| We assessed the presence of vascular endothelial growth factor ( VEGF ) C , VEGF D and their receptor VEGFR 3 by immunohistochemistry in 59 epithelial ovarian carcinomas , 11 borderline tumours and 20 benign cystadenomas . ^^^ A strong correlation was found between VEGF C and VEGF D detected in carcinoma and VEGFR 3 detected in neighbouring endothelial cells . ^^^ Increased expression of VEGF C , VEGF D and VEGFR 3 was significantly associated with lymph node metastasis and peritoneal metastasis outside the pelvis . ^^^ We conclude that VEGF C , VEGF D and VEGFR 3 play an important role in lymphatic spread and intraperitoneal tumour development in ovarian carcinoma . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| These TAMs also expressed the VEGF C and VEGF D specific tyrosine kinase receptor VEGFR 3 . ^^^ As TAMs are derived from monocytes in the circulation , a search in peripheral blood for candidate precursors of VEGFR 3 expressing TAMs revealed a subfraction of CD 14 positive , VEGFR 3 expressing monocytes , that , however , failed to express VEGF C and VEGF D . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Studies in animal models carried out over the past three years have shown that the soluble protein growth factors , vascular endothelial growth factor ( VEGF ) C and VEGF D , and their cognate receptor tyrosine kinase , VEGF receptor 3 ( VEGFR 3 ) , are critical regulators of lymphangiogenesis . ^^^ The capacity to induce lymphangiogenesis by manipulation of the VEGF C / VEGF D / VEGFR 3 signaling pathway offers new opportunities to understand the function of the lymphatic system and to develop novel treatments for lymphatic disorders . . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Two growth factors , vascular endothelial growth factor C ( VEGF C ) and D ( VEGF D ) , have been found to be important in the proper formation and maintenance of the lymphatic network , through their receptor VEGFR 3 . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Vessels in the parental tumours were found to express VEGFR 3 , the receptor for VEGF C and VEGF D . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| The expression and levels of the VEGF C and VEGF D cytokines , the VEGF receptors VEGFR 2 and VEGFR 3 , and newly described lymphatic endothelial markers , LYVE 1 , Prox 1 , podoplanin and 5 ' nucleotidase were assessed . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| They belong to the larger family which also includes VEGF , placenta growth factor ( PlGF ) and VEGF B , VEGF C and VEGF D are ligands for the endothelial cell specific tyrosine kinase receptors VEGFR 2 and VEGFR 3 . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| EXPERIMENTAL DESIGN : We assessed the levels of immunoreactivity for VEGF D and VEGFR 3 in 71 endometrial carcinomas , 14 complex atypical endometrial hyperplasias , and 16 normal endometria by immunohistochemistry . ^^^ A strong correlation was found between high levels of VEGF D immunoreactivity in carcinoma cells and VEGFR 3 in both carcinoma cells and adjacent endothelial cells . ^^^ Similarly , high levels of VEGF D immunoreactivity in stromal cells were significantly correlated with those of VEGFR 3 in both carcinoma cells and endothelial cells . ^^^ High levels of VEGF D in carcinoma cells and stromal cells , as well as those of VEGFR 3 in carcinoma cells and endothelial cells , were significantly related to myometrial invasion and lymph node metastasis . ^^^ A strong correlation was found between poor survival and high levels of VEGF D in both carcinoma cells and stromal cells and between poor survival and high levels of VEGFR 3 in carcinoma cells . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Inhibition of interaction of VEGFR 2 or VEGFR 3 with VEGF D but not of Tie 2 angiopoietin 1 interaction with soluble receptors abrogated Akt activation and survival of TEC . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| We studied the therapeutic potential of human vascular endothelial growth factor ( VEGF ) family members VEGF A , VEGF B , VEGF C , and VEGF D as well as a VEGFR 3 specific mutant ( VEGF C156S ) using adenoviral gene transfer in rabbit hindlimb skeletal muscle . ^^^ Full length VEGF C and VEGF D induced predominantly and the selective VEGFR 3 ligand VEGF C156S exclusively lymphangiogenesis . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| We measured the gene expression of VEGF ligands ( VEGF A , VEGF B , VEGF C , and VEGF D ) and their receptors ( VEGFR 1 , VEGFR 2 , and VEGFR 3 ) , in normal colorectal tissues ( n = 20 ) , adenomas ( n = 10 ) , and in CRC ( n = 71 ) representing different Duke ' s stages using ribonuclease protection assay , semi quantitative relative reverse transcriptase polymerase chain reaction , together with the pattern of their expression by immunohistochemistry . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Among them , VEGF C and VEGF D regulate the lymphatic vessels development and growth via their binding to their receptor VEGFR 3 . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Vascular endothelial growth factor ( VEGF ) C and VEGF D stimulate lymphangiogenesis and angiogenesis in tissues and tumors by activating the endothelial cell surface receptor tyrosine kinases VEGF receptor ( VEGFR ) 2 and VEGFR 3 . ^^^ Here , we report that the serine protease plasmin cleaved both propeptides from the VEGF homology domain of human VEGF D and thereby generated a mature form exhibiting greatly enhanced binding and cross linking of VEGFR 2 and VEGFR 3 in comparison to full length material . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| We studied the expression of VEGF D and its receptors ( VEGFR 2 and VEGFR 3 ) in normal and atherosclerotic human arteries , and compared that to the expression pattern of VEGF A . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Expression of vascular endothelial growth factor ( VEGF ) C and VEGF D , and their receptor VEGFR 3 , during different stages of cervical carcinogenesis . ^^^ The present study has assessed the expression of VEGF C and VEGF D , and their receptor VEGFR 3 , in 152 cervical lesions ( 33 CIN 1 , 33 CIN 2 , 37 CIN 3 , and 49 squamous cell carcinomas ) to determine whether expression of lymphangiogenic factors occurs prior to invasion . ^^^ A significant positive correlation was found between VEGF C , VEGF D , and VEGFR 3 expression through the different stages of cervical carcinogenesis . ^^^ Significant differences in protein expression for VEGF C , VEGF D , and VEGFR 3 were found between CIN 1 2 and CIN 3 ( p < 0 . 001 for all ) , but not between CIN 3 and cervical cancer . ^^^ Adjacent CIN 3 was present in nine cervical cancers and displayed strong expression for VEGF C , VEGF D , and VEGFR 3 . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Expression of mRNAs for VEGF C , VEGF D , and their receptor VEGFR 3 was examined by reverse transcription polymerase chain reaction ( RT PCR ) in six colon carcinoma cell lines and in fresh endoscopic biopsy specimens from 20 patients with colorectal carcinoma . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| The recent discovery and characterisation of the lymphangiogenic growth factors vascular endothelial growth factor C ( VEGF C ) and VEGF D and of their receptor on lymphatic endothelial cells , VEGFR 3 , has provided an understanding of the molecular mechanisms controlling the growth of lymphatic vessels . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Recently , a new member of the angiogenic molecule in VEGF family , VEGF D , has been identified that induces lymphangiogenesis via high affinity binding to VEGFR 3 . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| The recent discovery of lymphangiogenic growth factors vascular endothelial growth factor ( VEGF ) C and VEGF D and of their receptor , VEGFR 3 , on lymphatic endothelial cells has started to provide an understanding of the molecular mechanisms of lymphangiogenesis . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| We also examined whether VEGF addition and VEGF D addition cause phosphorylation of the mitogen activated protein kinase ( MAPK ) as well as VEGFR 2 and VEGFR 3 . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| The expression of VEGF C , VEGF D , VEGFR 3 and podoplanin mRNAs was assessed by real time quantitative PCR . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| The increased levels of VEGF D observed in the present study suggest that primary lymphedema may be based on defective stimulation of VEGFR 3 . . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| We characterized , at the mRNA and protein levels , the expression of VEGF A and VEGF D and their cognate receptors , VEGFR 1 , VEGFR 2 , and VEGFR 3 in early and advanced stage prostate cancer specimens . ^^^ CONCLUSIONS : Our results suggest that lymphangiogenic markers , such as VEGF D and VEGFR 2 and VEGFR 3 , may be better than angiogenic markers as targets of therapeutic intervention in advanced stage prostate disease . . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Vegf d , a secreted glycoprotein , is one of two known activating ligands for Vegfr 3 , the other being Vegf c . ^^^ The lack of a profound lymphatic phenotype in Vegf d deficient mice suggests that Vegf d does not play a major role in lymphatic development or that Vegf c or another , as yet unknown activating Vegfr 3 ligand can compensate for Vegf d during development . . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| In addition , the role of blood vascular vessel , lymph vessel , and Flt 4 positive vessel densities were studied in relation to their suspected association with lymph node metastasis , and with VEGF D expression . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Two members of the VEGF family , VEGF C and VEGF D are lymphangiogenic when activate VEGFR 3 . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Expression of mouse VEGF receptor ( VEGFR ) 2 and mouse VEGFR 3 mRNA was detected in the KKLS / VEGF C and KKLS / VEGF D gastric tumors . ^^^ CONCLUSION : VEGF C and VEGF D may induce neoformation of lymphatic vessels in experimental gastric tumors by the induction of VEGFR 3 expression . . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| In particular , lymphatic endothelial receptor tyrosine kinase VEGFR 3 , and its ligands VEGF C and VEGF D , are major players in promoting lymphatic vascular growth both during development and in pathological conditions . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| EXPERIMENTAL DESIGN : Real time quantitative reverse transcriptase PCR was used to measure levels of mRNA of tumor angiogenesis and lymphangiogenesis related factors [ vascular endothelial growth factor ( VEGF ) A , VEGF C , VEGF D , Flt 1 , KDR , Flt 4 , Ang 1 , Ang 2 , Tie 1 , Tie 2 , cyclooxygenase 2 , fibroblast growth factor 2 ( FGF 2 ) , Egr 1 , Prox 1 , and LYVE 1 ] in tumor specimens of 16 inflammatory breast cancer and 20 noninflammatory breast cancer patients . ^^^ RESULTS : Inflammatory breast cancer specimens had significantly higher mRNA expression levels than noninflammatory breast cancer specimens of the following genes : KDR ( P = 0 . 033 ) , Ang 1 , ( P = 0 . 0001 ) , Tie 1 ( P = 0 . 001 ) , Tie 2 ( P = 0 . 001 ) , FGF 2 ( P = 0 . 002 ) , VEGF C ( P = 0 . 001 ) , VEGF D ( P = 0 . 012 ) , Flt 4 ( P = 0 . 001 ) , Prox 1 ( P = 0 . 005 ) , and LYVE 1 ( P = 0 . 013 ) . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Airway dendritic cells , macrophages , neutrophils , and epithelial cells expressed the VEGFR 3 ligands VEGF C or VEGF D . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| VEGFR 3 , a receptor for the lymphatic growth factors VEGF C and VEGF D , but not for VEGF A , regulates vascular and lymphatic endothelial cell function during embryogenesis . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| To this end , the vascular endothelial growth factors VEGF C and VEGF D have been identified to promote lymphangiogenesis and lymphatic spread through activation of its receptor , Vascular endothelial growth factor receptor 3 ( VEGFR 3 ) . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| The receptor tyrosine kinase VEGFR 3 is virtually exclusively expressed on lymphatic but not blood endothelium in the adult , and activation of VEGFR 3 by its ligands VEGF C and VEGF D is sufficient to induce lymphangiogenesis . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| METHODS : Fifty pairs of normal mucosa and cancer specimens were obtained from patients who had undergone gastrectomy for primary gastric carcinoma and subjected to reverse transcriptase polymerase chain reaction for VEGF C , VEGF D , and VEGFR 3 . ^^^ VEGFR 3 expression was associated both with VEGF C and VEGF D expression , but not with lymph node metastasis . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Surprisingly , however , VEGF C and VEGF D , as well as VEGFR 3 , were expressed in some tumour types such as haemangioblastomas and glioblastomas , despite their lack of lymphatic vessels . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| The most extensively studied signaling system that promotes lymphangiogenesis in tumors involves the secreted lymphangiogenic proteins vascular endothelial growth factor C ( VEGF C ) and VEGF D , and their cognate receptor on lymphatic endothelium VEGF receptor 3 ( VEGFR 3 ) . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| The best validated molecular signalling system for tumour lymphangiogenesis involves the secreted proteins vascular endothelial growth factor C ( VEGF C ) and VEGF D that induce growth of lymphatic vessels via activation of VEGF receptor 3 ( VEGFR 3 ) localised on the surface of lymphatic endothelial cells . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Lymphatic vascular development is regulated by vascular endothelial growth factor receptor 3 ( VEGFR 3 ) , which is activated by its ligands VEGF C and VEGF D . ^^^ The functional importance of the interaction of NP 2 with the lymphangiogenic growth factors was demonstrated by cointernalization of NP 2 along with VEGFR 3 in endocytic vesicles of lymphatic endothelial cells upon stimulation with VEGF C or VEGF D . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| VEGFR 3 , VEGF C and VEGF D mRNA quantification by RT PCR in different human cell types . ^^^ The molecular events favoring lymphangiogenic pathways for tumor growth and dissemination are not perfectly understood , nor are the expression patterns of lymphangiogenic biomarkers such as the VEGFR 3 receptor and its ligands , VEGF C and VEGF D . ^^^ A quantitative RT PCR method was set up to measure the mRNA levels of VEGFR 3 , VEGF C and VEGF D . ^^^ It was found that , in contrast to VEGF D mRNA , the VEGFR 3 and VEGF C mRNAs were not expressed in all the cell types studied , and that blood cells expressed high VEGFR 3 mRNA levels compared to solid tumor cells . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Up regulated genes include vasculogenic growth factors such as VEGFA , VEGFC , FIGF ( VEGFD ) , ANG 1 , ANG 2 , TGFbeta 3 , and PDGFB , as well as the related receptors FLT 1 , FLT 4 , PDGFRB , TGFbetaR 2 , and TGFbetaR 3 , other markers such as CD 34 , VCAM 1 , PECAM 1 , VE CAD , and transcription factors TAL 1 , GATA 2 , and GATA 3 . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| VEGFA ( VEGF ) , VEGFB , VEGFC , VEGFD ( FIGF ) and PGF ( PlGF ) are VEGF family ligands for receptor tyrosine kinases , including VEGFR 1 ( FLT 1 ) , VEGFR 2 ( KDR ) and VEGFR 3 ( FLT 4 ) . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| Using a recombinant adenovirus encoding a soluble form of their receptor VEGFR 3 ( AdVEGFR 3 Ig ) , we studied lymphatic vessel dependency on VEGF C and VEGF D induced VEGFR 3 signaling in postnatal and adult mice . ^^^ |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43915 and P35916 |
Pubmed |
SVM Score :0.0 |
| NA |
|