| Interacting proteins: O15379 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q9Y618 |
Pubmed |
SVM Score :0.85080619 |
| Here we report that HDAC 3 interacts with SMRT only after priming by cellular chaperones including the TCP 1 ring complex ( TRiC ) , which is required for proper folding of HDAC 3 in an ATP dependent process . 0.85080619^^^ |
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| Interacting proteins: O15379 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| The SMRT and N CoR corepressors are activating cofactors for histone deacetylase 3 . ^^^ |
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| Interacting proteins: O15379 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Using a combination of conventional and immunoaffinity chromatography , we have successfully isolated a SMRT complex and identified histone deacetylase 3 ( HDAC 3 ) and transducin ( beta ) like 1 ( TBL 1 ) , a WD 40 repeat containing protein , as the subunits of the purified SMRT complex . ^^^ |
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| Interacting proteins: O15379 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| In this study , we demonstrate that Atx 1 interacts with the transcriptional corepressor SMRT ( silencing mediator of retinoid and thyroid hormone receptors ) and with histone deacetylase 3 . ^^^ |
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| Interacting proteins: O15379 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| In the initial phase , IKKalpha is responsible for derepressing the silencing mediator for retinoic acid and thyroid hormone receptor ( SMRT ) histone deacetylase 3 ( HDAC 3 ) corepressor complex from the p 50 homodimer . ^^^ |
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| Interacting proteins: O15379 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Here , we report that the transcription factor AP 4 and the corepressor geminin form a functional complex in which SMRT and histone deacetylase 3 are recruited . ^^^ |
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| Interacting proteins: O15379 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| A core SMRT corepressor complex containing HDAC 3 and TBL 1 , a WD 40 repeat protein linked to deafness . ^^^ It also contains HDAC 3 , a histone deacetylase not previously thought to interact with SMRT . ^^^ In vivo , TBL 1 is bridged to HDAC 3 through SMRT and can potentiate repression by TR . ^^^ |
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| Interacting proteins: O15379 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| We provide evidence that the transcriptional corepressors SMRT and N CoR could serve as critical mediators of HDAC 7 activity by binding class 2 HDACs and HDAC 3 by two distinct repressor domains . ^^^ Different class 2 HDACs reside in the cell nucleus in stable and autonomous complexes with enzymatic activity , but the enzymatic activities associated with HDAC 7 and HDAC 4 rely on shared cofactors , including HDAC 3 and SMRT / N CoR . . ^^^ |
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| Interacting proteins: O15379 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Corepressors N CoR and SMRT participate in diverse repression pathways and exist in large protein complexes including HDAC 3 , TBL 1 and TBLR 1 . ^^^ Together , our data reveal the roles of HDAC 3 and TBL / TBLR1 and provide evidence for the functional importance of histone interaction in repression mediated by SMRT N CoR complexes . . ^^^ |
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| Interacting proteins: O15379 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| IKKalpha induced phosphorylation coincides with a loss of chromatin associated SMRT and HDAC 3 and with nuclear export of the SMRT corepressor , events required for expression of the NF kappaB regulated cIAP 2 and IL 8 genes . ^^^ |
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| Interacting proteins: O15379 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Early studies have suggested that HDAC 3 activity is regulated by association with the corepressors N CoR and SMRT . ^^^ Here we demonstrate that , in addition to protein protein interactions with NCoR / SMRT , the activity of HDAC 3 is regulated by both phosphorylation and dephosphorylation . ^^^ |
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| Interacting proteins: O15379 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated recruitment of coactivators ( SRC 1 , SRC 2 , and SRC 3 ) and corepressors ( HDAC 1 , HDAC 2 , HDAC 3 , SMRT , and NCoR ) to the IkappaB alpha gene promoter after NF kappaB activation by tumor necrosis factor alpha . ^^^ The binding pattern suggests that the corepressor proteins formed two types of corepressor complexes , SMRT HDAC 1 and NCoR HDAC 3 . ^^^ |
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| Interacting proteins: O15379 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| The assembly of HDAC 3 with the deacetylase activation domain ( DAD ) of SMRT and NCoR is required for activation of the otherwise inert deacetylase . ^^^ |
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| Interacting proteins: O15379 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Surprisingly , progesterone mediated acetylation of histone H 4 was inhibited by MG 132 with the concomitant recruitment of HDAC 3 , NCoR , and SMRT . ^^^ |
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| Interacting proteins: O15379 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Involvement of the SMRT / NCoR HDAC 3 complex in transcriptional repression by the CNOT 2 subunit of the human Ccr 4 Not complex . ^^^ We found that coexpression of SMRT ( silencing mediator for retinoic acid receptor and thyroid hormone receptor ) or NCoR ( nuclear hormone receptor co repressor ) in combination with HDAC 3 ( or HDAC 5 and HDAC 6 ) augmented the repression by CNOT 2 . ^^^ We observed physical interactions of CNOT 2 with several subunits of the SMRT / NCoR HDAC 3 complex . ^^^ Our results show that the SMRT / NCoR HDAC 3 complex is a cofactor of CNOT 2 mediated repression and suggest that transcriptional regulation by the Ccr 4 Not complex involves regulation of chromatin modification . . ^^^ |
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| Interacting proteins: O15379 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| TBLR 1 co precipitates with SMRT , a co repressor of nuclear hormone receptors , and co precipitates in complexes immunoprecipitated by antiserum to HDAC 3 . ^^^ |
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