| Interacting proteins: Q8WUI4 and O15379 |
Pubmed |
SVM Score :0.0 |
| Human HDAC 7 histone deacetylase activity is associated with HDAC 3 in vivo . ^^^ The HDAC activity of HDAC 7 maps to a carboxyl terminal domain and is dependent on the interaction with the class 1 HDAC , HDAC 3 , in the cell nucleus . ^^^ Cytoplasmic HDAC 7 that is not bound to HDAC 3 is enzymatically inactive . ^^^ We provide evidence that the transcriptional corepressors SMRT and N CoR could serve as critical mediators of HDAC 7 activity by binding class 2 HDACs and HDAC 3 by two distinct repressor domains . ^^^ Different class 2 HDACs reside in the cell nucleus in stable and autonomous complexes with enzymatic activity , but the enzymatic activities associated with HDAC 7 and HDAC 4 rely on shared cofactors , including HDAC 3 and SMRT / N CoR . . ^^^ |
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| Interacting proteins: Q8WUI4 and O15379 |
Pubmed |
SVM Score :0.0 |
| By means of quantitative reverse transcription polymerase chain reaction using SYBR Green to detect double stranded DNA , mRNA expression profiles for histone deacetylases ( HDAC 1 , HDAC 2 , HDAC 3 , and HDAC 7 ) , histone acetyltransferases ( GCN 5 and HAT 1 ) , and histone H2A were established . ^^^ The HDAC 3 ( class 1 HDAC ) tends to have an expression profile similar to those of HDAC 1 , HDAC 2 , and HAT 1 , whereas the HDAC 7 ( class 2 HDAC ) and GCN 5 ( type A HAT ) profiles were different from those three . ^^^ |
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| Interacting proteins: Q8WUI4 and O15379 |
Pubmed |
SVM Score :0.0 |
| The N terminal region directs hr to a speckled nuclear pattern that co localizes with the histone deacetylase 3 ( HDAC ) , but not with HDAC 1 or HDAC 7 . ^^^ |
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| Interacting proteins: Q8WUI4 and O15379 |
Pubmed |
SVM Score :0.0 |
| CBZ inhibited HDAC 3 and HDAC 7 , which are representatives of HDAC class 1 and 2 respectively . ^^^ |
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| Interacting proteins: Q8WUI4 and O15379 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q8WUI4 and O15379 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WUI4 and O15379 |
Pubmed |
SVM Score :0.0 |
| NA |
|