| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.64956871 |
| In comparison with HDAC 1 and HDAC 2 , HDAC 3 remains relatively uncharacterized , and very few proteins have been shown to interact with HDAC 3 . 0.64956871^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Results of the HD 1 and HD 3 trials of the German Hodgkin Study Group . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Intermediate results of therapy studies HD 1 , HD 2 and HD 3 of the German Hodgkin Study Group ] . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| HDAC 3 is homologous to other human HDACs and yeast RPD 3 . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| We report herein the identification and characterization of HDAC 3 , a yeast RPD 3 ortholog in the mouse . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| HDRP does not possess intrinsic HDAC activity but forms complexes with both HDAC 1 and HDAC 3 . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The repression was augmented by increasing expression of HDAC 3 but not by HDAC 1 and was alleviated by trichostatin A . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis of these complexes suggests that hCtBP 1 associates with class 1 HDACs , HDAC 1 , HDAC 2 and HDAC 3 . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| When co expressed in mammalian cells , Gfi 1 associates with histone deacetylse 1 ( HDAC 1 ) , HDAC 2 , and HDAC 3 . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| It binds to CAF 1p48 , HDAC 1 and 2 , but not to CAF 1p60 , p 46 polypeptide and HDAC 3 . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| HDAC 3 but not HDAC 1 or HDAC 2 was required for AP 1 mediated stimulation of c jun expression . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Sequence alignments revealed that murine HD 1 is highly homologous to the yeast RPD 3 pleiotropic transcriptional regulator . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| AtHD 1 is a homolog of human HD 1 and RPD 3 global transcriptional regulator in yeast . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Herein we report that CBHA and SAHA inhibit histone deacetylase 1 ( HDAC 1 ) and histone deacetylase 3 ( HDAC 3 ) activity in vitro . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Here we show that endogenous N CoR , TBL 1 , and histone deacetylase 3 ( HDAC 3 ) , but not HDAC 1 , 2 , or 4 , are recruited to a stably integrated reporter gene repressed by unliganded TR as well as the orphan receptor RevErb . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The N terminal region directs hr to a speckled nuclear pattern that co localizes with the histone deacetylase 3 ( HDAC ) , but not with HDAC 1 or HDAC 7 . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Between July 1982 and June 1985 235 out of 436 untreated patients with Morbus Hodgkin ' s disease qualified for the protocols HD 1 ( stage IA to IIIA with risk factors ) , HD 2 ( stage IIIA ) and HD 3 ( stages IIIB and IVA / B ) . ^^^ The complete remission rates in HD 1 were 76 % ( COPP ) resp . 73 % ( COPP / ABVD ) , in HD 3 31 % ( COPP ) resp . 62 % ( COPP / ABVD ) . ^^^ Whereas COPP and COPP / ABVD achieved similar remission rates in low stages ( HD 1 ) , the combination COPP / ABVD seems to be superior to COPP alone for stages IIB / IVA / B ( HD 3 ) . . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Intermediate results of the study protocols HD 1 , HD 2 , and HD 3 ] . ^^^ Between July 1983 and September 1986 358 untreated patients with Hodgkin ' s lymphoma qualified for the protocols HD 1 ( stages 1 to IIIA with risk factors ) , HD 2 ( stage IIIA ) , and HD 3 ( stages IIIB and IVAB ) . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Between July 1983 and May 1987 143 untreated patients with Hodgkin ' s lymphoma in stages 1 IIIA with risk factors qualified for the HD 1 protocol , and 230 patients in stages IIIB / IV qualified for HD 3 . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Two clones , HCl and HC 2 , produced antibody capable of precipitating glycoprotein C and its precursor , whereas three clones , HD 1 , HD 2 , and HD 3 , produced antibody capable of precipitating glycoprotein D and its precursor . ^^^ Antibody produced by the HD 1 and HD 2 clones neutralized both HSV type 1 and HSV type 2 , whereas antibody produced by the HD 3 clone neutralized HSV type 1 but not HSV type 2 . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Significant antithrombic effect was exhibited by HD 1 , HD 2 , HD 3 , and HD 4 which decreased progressively . ^^^ Only HD 1 , HD 2 , and HD 3 augmented hemorrhagic activity but to a lower degree than UFH and LMWH . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| These domains , designated as HD 1 , HD 2 and HD 3 , are located between amino acid residues 160 and 204 , 247 and 298 , and 706 and 749 , respectively . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The novel benzoindane S 18126 possessed > 100 fold higher affinity at cloned , human ( h ) D 4 ( Ki = 2 . 4 nM ) vs . hD 2 ( 738 nM ) , hD 3 ( 2840 nM ) , hD 1 ( > 3000 nM ) and hD 5 ( > 3000 nM ) receptors and about 50 other sites , except sigma 1 receptors ( 1 . 6 nM ) . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| D 2 sites ( labeled by [ 125I ] iodosulpride ) was ( + ) S 14297 ( 61 ) approximately GR 103 , 691 ( 60 ) > U 99194 ( 14 ) > nafadotride ( 9 ) approximately ( + ) UH 232 ( 8 ) approximately ( + ) AJ 76 ( 6 ) > haloperidol ( 0 . 2 ) . ( + ) S 14297 and GR 103 , 691 also showed greater than 100 fold selectivity at dopamine hD 3 vs . hD 4 and hD 1 sites . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| In search of a cell line in which the D 3 dopamine receptor is expressed endogenously , we found that the neuron derived human medulloblastoma cell line TE 671 expresses the human D 3 ( hD 3 ) and D 1 ( hD 1 ) receptor , but neither the D 2 or D 4 receptors . ^^^ Exposure of TE 671 cells to the D 3 agonist 7 OH DPAT ( DPAT ) , or to the D 1 agonist SKF 38393 ( SKF ) increased the expression of hD 3 or hD 1 mRNA , respectively . ^^^ Moreover , whereas DPAT had no effect on hD 1 mRNA levels , stimulating the cells with SKF caused an increase in both hD 1 and hD 3 transcript levels . ^^^ These results suggest ( 1 ) that following ligand stimulation , hD 3 and hD 1 receptors are upregulated to enhance their own receptor expression , and ( 2 ) that upregulation of hD 1 receptor transcripts leads to a stimulation of the hD 3 dopamine receptor transcripts . . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| METHODS : A segment of the Huntington gene was amplified by PCR using the primers HD 1 and HD 3 flanking the CAG repeat sequence . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Meanwhile , a major photoperiod sensitive dominant genes Se 1 and other modified photoperiod sensitive genes : 1 Se 1 , E 3 , Hd 3 ( En Se 1 ) , Hd 5 and Hd 6 , were identified in Zhenshan 97A by crossing with QTL nearly isogenic lines : NIL ( Hd 1 ) , NIL ( Hd 2 ) , NIL ( Hd 3 ) , NIL ( Hd 5 ) and NIL ( Hd 6 ) . . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| B9H1 and B9H2 domains , and N terminal part of B9H3 domain were identical to HD 1 , HD 2 , and HD 3 domains conserved between human BCL 9 and Drosophila lgs . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| While mutation of the Phox2a homeodomain binding sites HD 1 , HD 2 , and HD 3 results in the loss of HAND2 / Phox2a transactivation of DBH , it is the interaction of HAND2 / Phox2a at the CRE / AP1 HD1 / 2 domains in the DBH enhancer that are required for synergistic activation by HAND 2 . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The HDAC 3 protein is 50 % identical in DNA sequence and 53 % identical in protein sequence compared with the previously cloned human HDAC 1 . ^^^ Similar to HDAC 1 and HDAC 2 , HDAC 3 is ubiquitously expressed in many different cell types . . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Characterization of a human RPD 3 ortholog , HDAC 3 . ^^^ We have screened the expressed sequence tag database ( National Center for Biotechnology Information ) with the yeast RPD 3 sequence and identified a human ortholog of RPD 3 , HDAC 3 . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Antibodies directed against endogenous HDAC 1 , HDAC 2 , or HDAC 3 immunoprecipitate histone deacetylase activity that is inhibited in vitro by the small molecule trapoxin ( TPX ) , and all three HDACs are retained by a TPX affinity matrix . ^^^ HDAC 1 and HDAC 2 are associated in HeLa cells in a complex that is predominantly separate from an HDAC 3 immune complex . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Human HDAC 1 , HDAC 2 , and HDAC 3 proteins are members of the first class , whereas no class 2 human HDAC proteins had been identified . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Northern blot analyses revealed that HDAC 8 expression pattern for HDAC 8 is distinct from that for HDAC 1 and HDAC 3 , and expression of HDAC 8 mRNA occurs in multiple organs including heart , lung , kidney , and pancreas . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| These mutations inhibited binding to HDAC 1 and 2 , which each contain an LXCXE like sequence , but had no effect on binding to HDAC 3 , which lacks an LXCXE like sequence . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Direct interaction of RIP 140 with HDAC 1 and HDAC 3 occurs in vitro and in vivo as demonstrated in co immunoprecipitation and glutathione S transferase pull down experiments . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Expression levels of HDAC 1 and HDAC 3 proteins , which varied among cell lines , but were stable during the treatment with FK 228 , did not correlate with the sensitivity to FK 288 . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the same HDAC 1 domain is also necessary for in vitro binding of HDAC 2 and HDAC 3 , association with RbAp 48 and for catalytic activity of the enzyme . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Class 1 members , such as HDAC 1 , HDAC 2 , HDAC 3 , and HDAC 8 , are well known enzymatic transcriptional corepressors homologous to yeast Rpd 3 . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Repression by Rb is mediated , at least in part , by a histone deacetylase complex , whose enzymatic activity relies on HDAC 1 , HDAC 2 or HDAC 3 . ^^^ Taken together , our data suggest a model in which Rb mediates the recruitment to E2F regulating promoters of a repressive complex containing either HDAC 1 , HDAC 2 or HDAC 3 and the histone binding protein RbAp48 . . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Previous studies have established that YY 1 interacts with histone acetyltransferases p 300 and CREB binding protein ( CBP ) and histone deacetylase 1 ( HDAC 1 ) , HDAC 2 , and HDAC 3 . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| In addition , of eight histone deacetylases ( HDACs ) tested , only the class 1 HDACs HDAC 1 , HDAC 2 , and HDAC 3 bind ETO . ^^^ Furthermore , ETO 2 binds HDAC 1 , HDAC 2 , and HDAC 3 but also interacts with HDAC 6 and HDAC 8 . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| GATA 2 directly associates with HDAC 3 but not with HDAC 1 . ^^^ Consistent with this , HDAC 3 suppressed the transcriptional potential of GATA 2 , whereas HDAC 1 did not affect GATA 2 dependent transcription . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Complexes shown to contain HDAC 1 , HDAC 3 , HDAC 6 , and HDAC1+2 as their catalytic subunits have been used in an antibody based assay that detects deacetylation of whole histones at defined lysines . ^^^ In comparison to HDAC 1 , HDAC 3 preferentially deacetylated lysines 5 and 12 of H 4 and lysine 5 of H2A . ^^^ H 4 tails in purified mononucleosomes were refractory to deacetylation by both HDAC 1 and HDAC 3 , unless ATP was added to the reaction mix . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| In humans , four highly homologous class 1 HDAC enzymes ( HDAC 1 , HDAC 2 , HDAC 3 , and HDAC 8 ) have been identified to date . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Furthermore , NAPP 2 functions as a corepressor and interacts specifically with histone deacetylase l ( HDAC 1 ) , but not HDAC 2 or HDAC 3 . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The expression of HDAC 2 and HDAC 3 is induced in HDAC 1 deficient cells , but can not compensate for loss of the enzyme , suggesting a unique function for HDAC 1 . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The AML 1 MTG16 fusion protein is targeted to the nucleoplasm where it is capable to oligomerize with MTG16a and interact with HDAC 1 and HDAC 3 . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| By means of quantitative reverse transcription polymerase chain reaction using SYBR Green to detect double stranded DNA , mRNA expression profiles for histone deacetylases ( HDAC 1 , HDAC 2 , HDAC 3 , and HDAC 7 ) , histone acetyltransferases ( GCN 5 and HAT 1 ) , and histone H2A were established . ^^^ The HDAC 3 ( class 1 HDAC ) tends to have an expression profile similar to those of HDAC 1 , HDAC 2 , and HAT 1 , whereas the HDAC 7 ( class 2 HDAC ) and GCN 5 ( type A HAT ) profiles were different from those three . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Our results support the hypothesis that the NF kappaB inhibitor IkappaBalpha regulates the transcriptional activity of homeodomain containing proteins positively through cytoplasmic sequestration of HDAC 1 and HDAC 3 , a mechanism that would assign a new and unexpected role to IkappaBalpha . . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| To further explore the catalytic activity of HDACs , we expressed two additional human class 1 HDACs , HDAC 1 and HDAC 3 , in baculovirus . ^^^ Recombinant HDAC 1 and HDAC 3 fusion proteins remained soluble and catalytically active and were purified to near homogeneity . ^^^ Interestingly , trichostatin ( TSA ) was found to be a potent inhibitor for all three HDACs ( IC 50 value of approximately 0 . 1 0 . 3 microM ) , whereas another HDAC inhibitor MS 27 275 ( N ( 2 aminophenyl ) 4 [ N ( pyridin 3 methyloxycarbonyl ) aminomethyl ] benzamide ) preferentially inhibited HDAC 1 ( IC 50 value of approximately 0 . 3 microM ) versus HDAC 3 ( IC 50 value of approximately 8 microM ) and had no inhibitory activity toward HDAC 8 ( IC 50 value > 100 microM ) . ^^^ HDAC 1 protein was more abundantly expressed in SW 620 cells compared with that of HDAC 3 and HDAC 8 . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The siRNA for HDAC 3 and HDAC 1 demonstrated significant morphological changes in HeLa S 3 consistent with those observed with HDAC inhibitors . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| To test the hypothesis that the delay reflected a dysfunction of ICP 0 in altering the structure of host protein viral DNA complexes , we examined the state of histone deacetylases ( HDACs ) ( HDAC 1 , HDAC 2 , and HDAC 3 ) . ^^^ We report the following . ( 1 ) HDAC 1 and HDAC 2 , but not HDAC 3 , were modified in infected cells . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Human class 1 HDACs possess homology to the yeast RPD 3 protein and include HDAC 1 , HDAC 2 , HDAC 3 , and HDAC 8 . ^^^ While HDAC 1 , HDAC 2 , and HDAC 3 have been characterized extensively , almost nothing is known about HDAC 8 . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Expression and functional characterization of recombinant human HDAC 1 and HDAC 3 . ^^^ Here we present the stable expression of human recombinant His tagged HDAC 1 and HDAC 3 in mammalian cells . ^^^ Full length human genes for HDAC 1 and HDAC 3 were cloned into the pcDNA 3 . 1 vector containing a N terminal His tag with an enterokinase cleavage site . ^^^ Western blots demonstrated the nickel affinity purified rhHDAC 1 preparation also contained endogenous HDAC 2 and HDAC 3 ; likewise , rhHDAC 3 preparation contained endogenous HDAC 1 and HDAC 2 . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Cyclin D 1 bound HDAC in vivo and preferentially physically associated with HDAC 1 , HDAC 2 , HDAC 3 , and HDAC 5 . ^^^ Chromatin immunoprecipitation assay demonstrated that cyclin D 1 enhanced recruitment of HDAC 1 and HDAC 3 and histone methyltransferase SUV39H1 to the PPAR response element of the lipoprotein lipase promoter and decreased acetylation of total histone H 3 and histone H 3 lysine 9 . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| HDAC 1 und HDAC 3 protein expression was analyzed immunohistochemically on a tissue microarray ( TMA ) containing 600 core biopsies from 200 patients . ^^^ Moderate or strong nuclear immunoreactivity for HDAC 1 was observed in 39 . 8 % and for HDAC 3 in 43 . 9 % of breast carcinomas . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Cell fractionation assays performed with primary human smooth muscle cells ( HSMCs ) showed that HDAC 8 , in contrast to HDAC 1 and HDAC 3 , was enriched in cytoskeleton bound protein fractions and insoluble cell pellets , suggesting an association of HDAC 8 with the cystoskeleton . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated recruitment of coactivators ( SRC 1 , SRC 2 , and SRC 3 ) and corepressors ( HDAC 1 , HDAC 2 , HDAC 3 , SMRT , and NCoR ) to the IkappaB alpha gene promoter after NF kappaB activation by tumor necrosis factor alpha . ^^^ The binding pattern suggests that the corepressor proteins formed two types of corepressor complexes , SMRT HDAC 1 and NCoR HDAC 3 . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Immunocytochemistry and Western blot were used to detect the expressions of histone deacetylase 1 , 3 , and 8 ( HDAC 1 , HDAC 3 , and HDAC 8 ) and acetylated histone H 4 ( Ac histone H 4 ) protein . ^^^ The expression levels of HDAC 1 , HDAC 3 , and HDAC 8 proteins were downregulated following curcumin treatment in Raji cells , whereas Ac histone H 4 protein expression was upregulated after treatment with curcumin . ^^^ CONCLUSION : Curcumin , as a new member of the histone deacetylase inhibitors , can inhibit the expression of class 1 HDACs ( HDAC 1 , HDAC 3 , and HDAC 8 ) , and can increase the expression of Ac histone H 4 in Raji cells . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| To understand the physiological functions of HDACs , we characterized six different Drosophila HDACs , including Rpd 3 , HDAC 3 , HDAC 4 , HDAC 6 S , HDAC 6 L , and Sir 2 , by developmental expression pattern , transcriptional profiles of target genes , and sensitivity to HDAC inhibitors . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Association of HDAC 3 and HDAC 1 with the relB VDR binding site was observed , but only HDAC 3 was reciprocally modulated by D ( 3 ) analog and LPS . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| To understand the difference between class 1 HDAC isoforms that could be exploited for the design of isoform specific HDAC inhibitors , we have built three dimensional models of four class 1 histone deacetylases , HDAC 1 , HDAC 2 , HDAC 3 , and HDAC 8 . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| In human colorectal tissue samples , the gene expressions of 4 coactivators , p 300 , pCAF , TIF 2 and TRAP 220 , and 7 corepressors , N CoR , REA , MTA 1 , MTA1L1 , HDAC 1 , HDAC 2 and HDAC 3 , linked to estrogen receptors ( ER ) , were revealed by traditional RT PCR . ^^^ The decline of mRNA levels of all coactivators and the increase of NCoR , HDAC 1 , HDAC 2 and MTA 1 were observed from normal to tumor tissue , whereas REA , HDAC 3 and MTA1L1 expressions were similar in both tissue compartments . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Similar to phosphorylation within the Rel homology domain of RelA / p65 , which governs an exchange of HDAC 1 for CBP / p300 acetyltransferases , we demonstrate that phosphorylation within the transactivation domain of RelA / p65 ( S 536 ) displaces SMRT HDAC 3 repressor activity , allowing p 300 to acetylate RelA / p65 . . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| CSE also reduced histone deacetylase ( HDAC ) activity and HDAC 1 , HDAC 2 , and HDAC 3 protein levels . ^^^ This was associated with posttranslational modification of HDAC 1 , HDAC 2 , and HDAC 3 protein by nitrotyrosine and aldehyde adduct formation . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Whereas a role for HDAC 1 and 2 in mediating components of the HDAC inhibitor response has been reported , the role of HDAC 3 is unknown . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The Nervy homology 2 ( NHR 2 ) domain in ETO mediates oligomerization and AML1 / ETO ' s interactions with ETO , MTGR 1 , and MTG 16 , and with the corepressor molecules mSin3A and HDAC 1 and HDAC 3 . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Significantly , E1A antisense was shown to co eliminate E1A 12 as well as HDAC 1 and HDAC 8 , but not HDAC 3 , from the enhancer repression complex . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Using different HDACi together with small interfering RNA for HDAC 1 , HDAC 2 , HDAC 3 , and HDAC 6 , we report that inhibition of HDAC 1 and HDAC 2 but not HDAC 3 , HDAC 6 , and HDAC 8 are primarily responsible for sensitization to TRAIL induced apoptosis . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation studies revealed that Tax co exists in a complex containing both histone deacetylase 1 ( HDAC 1 ) and 3 ( HDAC 3 ) . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Isolation and mapping of a human gene ( RPD3L1 ) that is homologous to RPD 3 , a transcription factor in Saccharomyces cerevisiae . ^^^ We have isolated a novel human gene RPD3L1 , that is highly homologous to a transcription factor in Saccharomyces cerevisiae , RPD 3 ( reduced potassium dependency 3 ) , from a human fetal lung cDNA library . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| A recently identified mammalian histone deacetylase ( HD 1 ) shows homology to the yeast Rpd 3 protein , which together with Sin 3 affects the transcription of several genes . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Searches of several sequence databases reveal that human HD 1 , yeast HDA 1 , yeast RPD 3 and other eukaryotic histone deacetylases share nine motifs with archaeal and eubacterial enzymes , including acetoin utilization protein ( acuC ) and acetylpolyamine amidohydrolase . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Recently , the mammalian histone deacetylase HD 1 was cloned from Jurkat T cells , and shown to be 60 % identical to the yeast global gene regulator Rpd 3 ( Taunton et al . , 1996 ) . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The interaction of the corepressors with the components involved in chromatin remodelling , such as the recruiting proteins Sin3A / B and the histone deacteylases HDAc 1 and RPD 3 , has been analysed in detail . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Histone deacetylases such as human HDAC 1 and yeast RPD 3 are trichostatin A ( TSA ) sensitive enzymes that are members of large , multiprotein complexes . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| In vitro , N CoR can interact with the Sin 3 corepressor , which in turn binds to the histone deacetylase Rpd 3 ( HDAC 1 ) , predicting the existence of a corepressor complex containing N CoR , Sin 3 , and histone deacetylase . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| We show that Drosophila Hdac 1 , an Rpd 3 type gene , interacts cooperatively with Polycomb group repressors in silencing the homeotic genes that are essential for axial patterning of body segments . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The OsHDAC 1 gene encoded a protein of approximately 57 kDa that shared 73 . 5 , 72 . 7 , 79 . 9 , and 57 . 1 % amino acid sequence identity with the OsHDAC 2 , OsHDAC 3 , maize RPD 3 , and human HDAC 1 proteins , respectively . ^^^ |
|
| Interacting proteins: O15379 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Arabidopsis thaliana histone deacetylase 1 ( AtHD 1 or AtHDA 19 ) , a homolog of yeast RPD 3 , is a global regulator of many physiological and developmental processes in plants . ^^^ |
|